Waldenström's macroglobulinemia(patient information): Difference between revisions
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{{Waldenström's macroglobulinemia (patient information)}} | |||
| | '''For the WikiDoc page for this topic, click [[ Waldenstrom's macroglobulinemia |here]]''' | ||
[[{{ | {{CMG}}; {{AE}} {{ADI}}; {{GRR}} {{Nat}} | ||
==Overview== | |||
Macroglobulinemia of Waldenstrom is a [[cancer]] of the B [[B Lymphocytes|lymphocytes]] (a type of white blood cell). It is associated with the overproduction of [[proteins]] called [[IgM]] [[antibodies]].<ref name="urlMacroglobulinemia of Waldenstrom: MedlinePlus Medical Encyclopedia">{{cite web |url=http://www.nlm.nih.gov/medlineplus/ency/article/000588.htm |title=Macroglobulinemia of Waldenstrom: MedlinePlus Medical Encyclopedia |format= |work= |accessdate=}}</ref> | |||
==What are the symptoms of Waldenström's macroglobulinemia?== | |||
* [[Bleeding of the gums]] | |||
* [[Blurred or decreased vision]] | |||
* [[Dizziness]] | |||
* Easy [[bruising]] of the [[skin]] | |||
* [[Fatigue]] | |||
* [[Headache]] | |||
* Mental status changes | |||
* [[Nosebleeds]] | |||
* [[Numbness]], [[tingling]], or burning [[pain]] in the hands, feet, fingers, toes, ears, or nose | |||
* [[Rash]] | |||
* Unintentional [[weight loss]] | |||
* Vision loss in one eye | |||
Additional symptoms that may be associated with this disease: | |||
* Bluish skin discoloration | |||
* Fingers that change color upon pressure | |||
* [[Flank pain]] | |||
* Swollen glands | |||
==What causes Waldenström's macroglobulinemia?== | |||
Waldenstrom's macroglobulinemia is a result of a condition called [[lymphoplasmacytic lymphoma]]. The cause of the overproduction of the IgM antibody is unknown, but researchers believe it is made by lymphoma cells. | |||
Overproduction of IgM causes the blood to become too thick. This is called hyper-viscosity. It occasionally makes it harder for blood to flow through small blood vessels. | |||
About 1,500 people in the United States are diagnosed with Waldenstrom's macroglobulinemia every year. Most people with this condition are over age 65; however, it may also occur in younger people. | |||
== Diagnosis == | |||
Signs may include: | |||
* Swollen/[[enlarged spleen]] | |||
* Swollen/[[enlarged liver]] | |||
* Swollen/[[enlarged lymph nodes]] | |||
* An eye exam may show enlarged veins in the [[retina]] or [[retinal bleeding]] ([[hemorrhages]]). | |||
Tests may include: | |||
[[ | * [[Complete blood count]] (CBC) - shows a low number of red blood cells and [[platelets]] | ||
* [[Blood chemistry tests|Blood chemistry]] - evidence of [[kidney disease]] | |||
* Serum viscosity test | |||
* [[Serum protein electrophoresis]] - increased amount of the [[IgM]] [[antibody]]. Levels seen in Waldenstrom's macroglobulinemia are generally greater than 3 g/dL. | |||
* [[Bone marrow examination]] - show cells that resemble both [[lymphocytes]] and [[plasma cells]] | |||
Additional tests that may be done: | |||
* 24-hour urine protein | |||
* [[Total protein]] | |||
* [[Electrophoresis|Serum globulin electrophoresis]] | |||
* [[Immunofixation]] in urine | |||
* T (thymus derived) lymphocyte count | |||
==When to seek urgent medical care?== | |||
Call your health care provider if any symptoms of this disorder develop. | |||
==Treatment== | |||
| | * [[Plasmapheresis]] - removes unwanted substances from the blood. In macroglobulinemia, this treatment removes or reduces the high levels of [[Immunoglobulin M|IgM]] and is used to quickly control the symptoms caused by blood thickening. | ||
* Drug therapy - may include [[steroids]], [[Leukeran]], [[Alkeran]], [[Cytoxan]], [[fludarabine]], or [[rituximab]], or combinations of [[chemotherapy]] drugs. | |||
[[ | * Patients who have a low number of red or [[white blood cells]] or [[platelets]] may need [[transfusions]] or [[antibiotics]]. | ||
==What to expect (Outlook/Prognosis)?== | |||
The average survival is about 6.5 years. Some people live more than 10 years. In some people, Waldenström's macroglobulinemia may produce few symptoms and progress slowly. | |||
==Possible complications== | |||
* Changes in mental function, possibly leading to [[coma]] | |||
* [[Congestive heart failure]] | |||
* [[Gastrointestinal bleeding]] | |||
* [[Vision problems]] | |||
==Sources== | |||
{{reflist|2}} | |||
{{WH}} | |||
{{WS}} | |||
[[ | [[Category:Patient information]] | ||
Latest revision as of 17:25, 8 April 2019
Template:Waldenström's macroglobulinemia (patient information)
For the WikiDoc page for this topic, click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]
Overview
Macroglobulinemia of Waldenstrom is a cancer of the B lymphocytes (a type of white blood cell). It is associated with the overproduction of proteins called IgM antibodies.[1]
What are the symptoms of Waldenström's macroglobulinemia?
- Bleeding of the gums
- Blurred or decreased vision
- Dizziness
- Easy bruising of the skin
- Fatigue
- Headache
- Mental status changes
- Nosebleeds
- Numbness, tingling, or burning pain in the hands, feet, fingers, toes, ears, or nose
- Rash
- Unintentional weight loss
- Vision loss in one eye
Additional symptoms that may be associated with this disease:
- Bluish skin discoloration
- Fingers that change color upon pressure
- Flank pain
- Swollen glands
What causes Waldenström's macroglobulinemia?
Waldenstrom's macroglobulinemia is a result of a condition called lymphoplasmacytic lymphoma. The cause of the overproduction of the IgM antibody is unknown, but researchers believe it is made by lymphoma cells.
Overproduction of IgM causes the blood to become too thick. This is called hyper-viscosity. It occasionally makes it harder for blood to flow through small blood vessels.
About 1,500 people in the United States are diagnosed with Waldenstrom's macroglobulinemia every year. Most people with this condition are over age 65; however, it may also occur in younger people.
Diagnosis
Signs may include:
- Swollen/enlarged spleen
- Swollen/enlarged liver
- Swollen/enlarged lymph nodes
- An eye exam may show enlarged veins in the retina or retinal bleeding (hemorrhages).
Tests may include:
- Complete blood count (CBC) - shows a low number of red blood cells and platelets
- Blood chemistry - evidence of kidney disease
- Serum viscosity test
- Serum protein electrophoresis - increased amount of the IgM antibody. Levels seen in Waldenstrom's macroglobulinemia are generally greater than 3 g/dL.
- Bone marrow examination - show cells that resemble both lymphocytes and plasma cells
Additional tests that may be done:
- 24-hour urine protein
- Total protein
- Serum globulin electrophoresis
- Immunofixation in urine
- T (thymus derived) lymphocyte count
When to seek urgent medical care?
Call your health care provider if any symptoms of this disorder develop.
Treatment
- Plasmapheresis - removes unwanted substances from the blood. In macroglobulinemia, this treatment removes or reduces the high levels of IgM and is used to quickly control the symptoms caused by blood thickening.
- Drug therapy - may include steroids, Leukeran, Alkeran, Cytoxan, fludarabine, or rituximab, or combinations of chemotherapy drugs.
- Patients who have a low number of red or white blood cells or platelets may need transfusions or antibiotics.
What to expect (Outlook/Prognosis)?
The average survival is about 6.5 years. Some people live more than 10 years. In some people, Waldenström's macroglobulinemia may produce few symptoms and progress slowly.
Possible complications
- Changes in mental function, possibly leading to coma
- Congestive heart failure
- Gastrointestinal bleeding
- Vision problems