Methemoglobinemia epidemiology and demographics: Difference between revisions

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{{Methemoglobinemia}}
{{Methemoglobinemia}}
{{CMG}}; {{AE}}{{Aksiniya K. Stevasarova, M.D.}}
{{CMG}}; {{AE}}{{AKS}}


==Overview==
==Overview==
 
The incidence of congenital methemoglobinemia in the United States is very low. There is no racial predilection to [[methemoglobinemia]]. The highest prevalence of [[G6PD deficiency]] is observed in the malaria-endemic regions: Sub-Saharan Afria, West Asia and Arabian Peninsula, as well as in people of Mediterranean descent.
'''Congenital (Hereditary) Methemoglobinemia'''
 
There are three main congenital conditions that lead to methemoglobinemia:
 
1. [[Cytochrome b5 reductase]] deficiency and [[pyruvate kinase]] deficiency
 
2. [[G6PD deficiency]]
 
3. Presence of abnormal hemoglobin ([[Hb M]])
 
 
'''Acquired or Acute Methemoglobinemia'''
 
Most common cause include different [[oxidant drugs]], toxins or chemicals


==Epidemiology and Demographics==
==Epidemiology and Demographics==


'''Epidemiology'''
The incidence of congenital methemoglobinemia in the United States is very low.  
 
In the United States congenital methemoglobinemia is rare. Deficiency of cytochrome b5 reductase endemic only in some Native American tribes like Navajo <ref>{{J Pediatr. 1964 Dec;65:928-31.
HEREDITARY METHEMOGLOBINEMIA DUE TO DIAPHORASE DEFICIENCY IN NAVAJO INDIANS.
BALSAMO P, HARDY WR, SCOTT EM. pmid=14244100}}</ref>  and Athabaskan Alaskans, and the Yakutsk people in Siberia. <ref>{{J Pediatr Hematol Oncol. 2017 Jan;39(1):42-45.
Enzymopenic Congenital Methemoglobinemia in Children of the Republic of Sakha (Yakutia).
Burtseva TE1, Ammosova TN, Protopopova NN, Yakovleva SY, Slobodchikova MP. pmid=27879543 }}</ref>
 
The acquired methemoglobinemia is the most common form, and most cases are related to topical or local anesthetic use during medical procedures.  


'''Demographics'''
===Age===
* Patients of all age groups may develop [[methemoglobinemia]].
* The acquired methemoglobinemia is a rare disease that tends to affect infants and people exposed to local anesthetics during medical procedures.
* Infants, particularly those younger than 4 months are most susceptible to [[methemoglobinemia]]. This is due to the fact that the [[NADH methemoglobin reductase]] activity and concentration (the main protective [[enzyme]] against [[oxidative stress]]) is not fully mature in infants.


Infants, particularly those younger than 4 months are most susceptible to methemoglobinemia. This is due to the fact that the NADH methemoglobin reductase activity and concentration (the main protective enzyme against oxidative stress) is not fully mature in infants.
===Gender===
Both cytochrome b5 reductase deficiency and pyruvate kinase deficiency are autosomal recessive diseases and the Hb M has autosomal dominant pattern of inheritance.  
* The incidence of the congenital [[methemoglobinemia]] is the same for both genders as both [[cytochrome b5 reductase deficiency]] and [[pyruvate kinase deficiency]] are [[autosomal recessive diseases]] and the [[Hb M]] has [[autosomal dominant pattern of inheritance]].  
On the other hand G6PD deficiency is X-linked, therefore the risk of acquired methemoglobinemia is greater in males. The highest prevalence of G6PD deficiency is observed in the malaria-endemic regions: Sub-Saharan Afria, West Asia and Arabian Peninsula, as well as in people of Mediterranean descent. As a result these populations are at higher risk for acquired methemoglobinemia.  <ref>{{Malar J. 2013 Nov 15;12:418. doi: 10.1186/1475-2875-12-418.
* The incidence of ([G6PD]] deficiency is is greater in males as this condition has [[X-linked pattern of inheritance]]. There is no racial predilection to Methemoglobinemia.  
Spatial distribution of G6PD deficiency variants across malaria-endemic regions.
Howes RE1, Dewi M, Piel FB, Monteiro WM, Battle KE, Messina JP, Sakuntabhai A, Satyagraha AW, Williams TN, Baird JK, Hay SI. pmid=24228846 }}</ref>  <ref>{{ Adv Parasitol. 2013;81:133-201. doi: 10.1016/B978-0-12-407826-0.00004-7.
G6PD deficiency: global distribution, genetic variants and primaquine therapy.
Howes RE1, Battle KE, Satyagraha AW, Baird JK, Hay SI.pmid=23384623}}</ref>  <ref>{{ pmid=1917622}}</ref>


===Developed Countries===
*There is no racial predilection to [[methemoglobinemia]].
*In developed countries, the incidence of acquired methemoglobinemia is higher in developing countries when people are exposed to local anesthetics during various medical procedures.
*The majority of [[cytochrome b5 reductase deficiency]] cases are found among some Native American tribes like Navajo <ref name="pmid14244100">{{cite journal| author=BALSAMO P, HARDY WR, SCOTT EM| title=HEREDITARY METHEMOGLOBINEMIA DUE TO DIAPHORASE DEFICIENCY IN NAVAJO INDIANS. | journal=J Pediatr | year= 1964 | volume= 65 | issue=  | pages= 928-31 | pmid=14244100 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14244100  }} </ref> and Athabaskan Alaskans, and the Yakutsk people in Siberia. <ref name="pmid27879543">{{cite journal| author=Burtseva TE, Ammosova TN, Protopopova NN, Yakovleva SY, Slobodchikova MP| title=Enzymopenic Congenital Methemoglobinemia in Children of the Republic of Sakha (Yakutia). | journal=J Pediatr Hematol Oncol | year= 2017 | volume= 39 | issue= 1 | pages= 42-45 | pmid=27879543 | doi=10.1097/MPH.0000000000000705 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27879543  }} </ref>


  {{Reflist|2}}
===Developing Countries===
*The highest prevalence of [[G6PD deficiency]] is observed in the malaria-endemic regions: Sub-Saharan Afria, West Asia and Arabian Peninsula, as well as in people of Mediterranean descent. <ref name="pmid24228846">{{cite journal| author=Howes RE, Dewi M, Piel FB, Monteiro WM, Battle KE, Messina JP et al.| title=Spatial distribution of G6PD deficiency variants across malaria-endemic regions. | journal=Malar J | year= 2013 | volume= 12 | issue= | pages= 418 | pmid=24228846 | doi=10.1186/1475-2875-12-418 | pmc=3835423 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24228846  }} </ref>  <ref name="pmid23384623">{{cite journal| author=Howes RE, Battle KE, Satyagraha AW, Baird JK, Hay SI| title=G6PD deficiency: global distribution, genetic variants and primaquine therapy. | journal=Adv Parasitol | year= 2013 | volume= 81 | issue=  | pages= 133-201 | pmid=23384623 | doi=10.1016/B978-0-12-407826-0.00004-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23384623  }} </ref>  <ref name="pmid1917622">{{cite journal| author=Lawton CA, Won M, Pilepich MV, Asbell SO, Shipley WU, Hanks GE et al.| title=Long-term treatment sequelae following external beam irradiation for adenocarcinoma of the prostate: analysis of RTOG studies 7506 and 7706. | journal=Int J Radiat Oncol Biol Phys | year= 1991 | volume= 21 | issue= 4 | pages= 935-9 | pmid=1917622 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1917622  }} </ref>


==References==
==References==

Latest revision as of 20:58, 31 July 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aksiniya Stevasarova, M.D.

Overview

The incidence of congenital methemoglobinemia in the United States is very low. There is no racial predilection to methemoglobinemia. The highest prevalence of G6PD deficiency is observed in the malaria-endemic regions: Sub-Saharan Afria, West Asia and Arabian Peninsula, as well as in people of Mediterranean descent.

Epidemiology and Demographics

The incidence of congenital methemoglobinemia in the United States is very low.

Age

  • Patients of all age groups may develop methemoglobinemia.
  • The acquired methemoglobinemia is a rare disease that tends to affect infants and people exposed to local anesthetics during medical procedures.
  • Infants, particularly those younger than 4 months are most susceptible to methemoglobinemia. This is due to the fact that the NADH methemoglobin reductase activity and concentration (the main protective enzyme against oxidative stress) is not fully mature in infants.

Gender

Developed Countries

  • There is no racial predilection to methemoglobinemia.
  • In developed countries, the incidence of acquired methemoglobinemia is higher in developing countries when people are exposed to local anesthetics during various medical procedures.
  • The majority of cytochrome b5 reductase deficiency cases are found among some Native American tribes like Navajo [1] and Athabaskan Alaskans, and the Yakutsk people in Siberia. [2]

Developing Countries

  • The highest prevalence of G6PD deficiency is observed in the malaria-endemic regions: Sub-Saharan Afria, West Asia and Arabian Peninsula, as well as in people of Mediterranean descent. [3] [4] [5]

References

  1. BALSAMO P, HARDY WR, SCOTT EM (1964). "HEREDITARY METHEMOGLOBINEMIA DUE TO DIAPHORASE DEFICIENCY IN NAVAJO INDIANS". J Pediatr. 65: 928–31. PMID 14244100.
  2. Burtseva TE, Ammosova TN, Protopopova NN, Yakovleva SY, Slobodchikova MP (2017). "Enzymopenic Congenital Methemoglobinemia in Children of the Republic of Sakha (Yakutia)". J Pediatr Hematol Oncol. 39 (1): 42–45. doi:10.1097/MPH.0000000000000705. PMID 27879543.
  3. Howes RE, Dewi M, Piel FB, Monteiro WM, Battle KE, Messina JP; et al. (2013). "Spatial distribution of G6PD deficiency variants across malaria-endemic regions". Malar J. 12: 418. doi:10.1186/1475-2875-12-418. PMC 3835423. PMID 24228846.
  4. Howes RE, Battle KE, Satyagraha AW, Baird JK, Hay SI (2013). "G6PD deficiency: global distribution, genetic variants and primaquine therapy". Adv Parasitol. 81: 133–201. doi:10.1016/B978-0-12-407826-0.00004-7. PMID 23384623.
  5. Lawton CA, Won M, Pilepich MV, Asbell SO, Shipley WU, Hanks GE; et al. (1991). "Long-term treatment sequelae following external beam irradiation for adenocarcinoma of the prostate: analysis of RTOG studies 7506 and 7706". Int J Radiat Oncol Biol Phys. 21 (4): 935–9. PMID 1917622.

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