Tweety family member 2: Difference between revisions

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{{Underlinked|date=September 2014}}
{{Infobox_gene}}
{{Infobox_gene}}
 
'''Tweety family member 2''' is a [[protein]] that in humans is encoded by the TTYH2 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Tweety family member 2 | url = https://www.ncbi.nlm.nih.gov/gene/94015}}</ref> Members of this family function as [[chloride channel]]s. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney [[tumorigenesis]]. Two transcript variants encoding distinct isoforms have been identified for this gene.
'''Tweety family member 2''' is a [[protein]] that in humans is encoded by the TTYH2 [[gene]].
<ref name="entrez">
{{cite web
| title = Entrez Gene: Tweety family member 2
| url = https://www.ncbi.nlm.nih.gov/gene/94015
| accessdate = 2014-09-11 <!-- T11:05:18.375677-08:00 -->
}}</ref>
 
==Function==
 
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
 
{{refbegin}}
{{refbegin | 2}}
* {{cite journal | vauthors = Bisson N, James DA, Ivosev G, Tate SA, Bonner R, Taylor L, Pawson T | title = Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor | journal = Nature Biotechnology | volume = 29 | issue = 7 | pages = 653–8 | date = June 2011 | pmid = 21706016 | pmc = | doi = 10.1038/nbt.1905 }}
*{{Cite journal  
* {{cite journal | vauthors = Ibarrola N, Molina H, Iwahori A, Pandey A | title = A novel proteomic approach for specific identification of tyrosine kinase substrates using [13C]tyrosine | journal = The Journal of Biological Chemistry | volume = 279 | issue = 16 | pages = 15805–13 | date = April 2004 | pmid = 14739304 | doi = 10.1074/jbc.M311714200 }}
| last1 = Bisson | first1 = N.
* {{cite journal | vauthors = Rae FK, Hooper JD, Eyre HJ, Sutherland GR, Nicol DL, Clements JA | title = TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma | journal = Genomics | volume = 77 | issue = 3 | pages = 200–7 | date = October 2001 | pmid = 11597145 | doi = 10.1006/geno.2001.6629 }}
| last2 = James | first2 = D. A.
* {{cite journal | vauthors = Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M | title = TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation | journal = World Journal of Gastroenterology | volume = 13 | issue = 19 | pages = 2717–21 | date = May 2007 | pmid = 17569141 | pmc = 4147121 | doi=10.3748/wjg.v13.i19.2717}}
| last3 = Ivosev | first3 = G.
* {{cite journal | vauthors = Suzuki M, Mizuno A | title = A novel human Cl(-) channel family related to Drosophila flightless locus | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 22461–8 | date = May 2004 | pmid = 15010458 | doi = 10.1074/jbc.M313813200 }}
| last4 = Tate | first4 = S. A.
* {{cite journal | vauthors = He Y, Ramsay AJ, Hunt ML, Whitbread AK, Myers SA, Hooper JD | title = N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2) | journal = The Biochemical Journal | volume = 412 | issue = 1 | pages = 45–55 | date = May 2008 | pmid = 18260827 | doi = 10.1042/BJ20071722 }}
| last5 = Bonner | first5 = R.
* {{cite journal | vauthors = He Y, Hryciw DH, Carroll ML, Myers SA, Whitbread AK, Kumar S, Poronnik P, Hooper JD | title = The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels | journal = The Journal of Biological Chemistry | volume = 283 | issue = 35 | pages = 24000–10 | date = August 2008 | pmid = 18577513 | pmc = 3259790 | doi = 10.1074/jbc.M803361200 }}
| last6 = Taylor | first6 = L.
| last7 = Pawson | first7 = T.
| doi = 10.1038/nbt.1905
| title = Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor  
| journal = Nature Biotechnology  
| volume = 29  
| issue = 7  
| pages = 653–658
| year = 2011  
| pmid = 21706016  
| pmc =  
}}
*{{Cite journal
| pmid = 14739304
| year = 2004
| author1 = Ibarrola
| first1 = N
| title = A novel proteomic approach for specific identification of tyrosine kinase substrates using 13Ctyrosine
| journal = Journal of Biological Chemistry
| volume = 279
| issue = 16
| pages = 15805–13
| last2 = Molina
| first2 = H
| last3 = Iwahori
| first3 = A
| last4 = Pandey
| first4 = A
| doi = 10.1074/jbc.M311714200
}}
*{{Cite journal
| pmid = 11597145
| year = 2001
| author1 = Rae
| first1 = F. K.
| title = TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma
| journal = Genomics
| volume = 77
| issue = 3
| pages = 200–7
| last2 = Hooper
| first2 = J. D.
| last3 = Eyre
| first3 = H. J.
| last4 = Sutherland
| first4 = G. R.
| last5 = Nicol
| first5 = D. L.
| last6 = Clements
| first6 = J. A.
| doi = 10.1006/geno.2001.6629
}}
*{{Cite journal
| pmid = 17569141
| pmc = 4147121
| year = 2007
| author1 = Toiyama
| first1 = Y
| title = TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation
| journal = World Journal of Gastroenterology
| volume = 13
| issue = 19
| pages = 2717–21
| last2 = Mizoguchi
| first2 = A
| last3 = Kimura
| first3 = K
| last4 = Hiro
| first4 = J
| last5 = Inoue
| first5 = Y
| last6 = Tutumi
| first6 = T
| last7 = Miki
| first7 = C
| last8 = Kusunoki
| first8 = M
}}
*{{Cite journal
| pmid = 15010458
| year = 2004
| author1 = Suzuki
| first1 = M
| title = A novel human Cl(-) channel family related to Drosophila flightless locus
| journal = Journal of Biological Chemistry
| volume = 279
| issue = 21
| pages = 22461–8
| last2 = Mizuno
| first2 = A
| doi = 10.1074/jbc.M313813200
}}
*{{Cite journal
| pmid = 18260827
| year = 2008
| author1 = He
| first1 = Y
| title = N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: Impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2)
| journal = Biochemical Journal
| volume = 412
| issue = 1
| pages = 45–55
| last2 = Ramsay
| first2 = A. J.
| last3 = Hunt
| first3 = M. L.
| last4 = Whitbread
| first4 = A. K.
| last5 = Myers
| first5 = S. A.
| last6 = Hooper
| first6 = J. D.
| doi = 10.1042/BJ20071722
}}
*{{Cite journal
| pmid = 18577513
| pmc = 3259790
| year = 2008
| author1 = He
| first1 = Y
| title = The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels
| journal = Journal of Biological Chemistry
| volume = 283
| issue = 35
| pages = 24000–10
| last2 = Hryciw
| first2 = D. H.
| last3 = Carroll
| first3 = M. L.
| last4 = Myers
| first4 = S. A.
| last5 = Whitbread
| first5 = A. K.
| last6 = Kumar
| first6 = S
| last7 = Poronnik
| first7 = P
| last8 = Hooper
| first8 = J. D.
| doi = 10.1074/jbc.M803361200
}}


{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}


{{gene-17-stub}}
{{gene-17-stub}}

Latest revision as of 16:22, 6 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tweety family member 2 is a protein that in humans is encoded by the TTYH2 gene.[1] Members of this family function as chloride channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene.

References

  1. ↑ "Entrez Gene: Tweety family member 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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