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==Overview==
==Overview==
==Medical therapy==
[[Chemotherapy]] is recommended among all patients who develop myelodysplastic syndrome.<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
Treatment is based on the type of MDS and the person's age and general health. The goal of treatment for MDS is to:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
==Medical Therapy==
*Relieve symptoms
*Treatment is based on the type of myelodysplastic syndrome and the person's age and general health. The goal of treatment for myelodysplastic syndrome is to:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
*Slow or prevent progression of the disease
**Relieve symptoms
*Improve quality of life
**Slow or prevent progression of the disease
**Improve quality of life
===Chemotherapy===
===Chemotherapy===
Chemotherapy is the use of anti-cancer (cytotoxic) drugs to treat cancer. It may also be used to treat people whose MDS progresses to acute myelogenous leukemia.
*The most common chemotherapy drug used to treat myelodysplastic syndrome is cytarabine. Cytarabine may be combined with other pharmacological agents such as:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
The most common chemotherapy drug used to treat MDS is cytarabine (Cytosar, Ara-C). Cytarabine may be combined with:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
**[[Idarubicin]]
 
**[[Topotecan]]
*Idarubicin (Idamycin)
**[[Fludarabine]]
 
* Other chemotherapeutic agents that may be used to treat myelodysplastic syndrome include:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
*Topotecan (Hycamtin)
**[[Daunorubucin]]
 
**[[Mitoxantrone]]
*Fludarabine (Fludara)
===Supportive Therapy===
 
*Supportive therapy is given to relieve symptoms and lessen the problems caused by abnormal blood cell counts or treatment for myelodysplastic syndrome.<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
Other chemotherapy drugs that may be used to treat MDS include:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
*Daunorubucin (Cerubidine)
*Mitoxantrone (Novantrone)
===Supportive therapy===
 
Supportive therapy is given to relieve symptoms and lessen the problems caused by abnormal blood cell counts or treatment for MDS.
====Transfusions====
====Transfusions====
 
*Patients with anemia may receive blood transfusions to correct the red blood cell counts.
People with low red blood cell counts (anemia) may be given blood transfusions.
*Frequent blood transfusions can be complicated by a buildup of extra iron in the body, which is treated with drug therapy.
 
*Patients with bleeding problems due to low platelet counts may be given platelet transfusions.
Frequent blood transfusions can result in a buildup of extra iron, which is treated with drug therapy.
====Growth Factors====
 
*[[Epoetin]] (erythropoietin)
People with bleeding problems due to low platelet counts may be given platelet transfusions.
 
====Growth factors====
Shortages of blood cells cause most of the symptoms of MDS. Growth factors help return blood cell counts to normal.<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
 
*Epoetin (Eprex, erythropoietin)
:*Helps improve production of red blood cells
:*Helps improve production of red blood cells
 
*[[Filgrastim]]
*Filgrastim (Neupogen)
:*Also called granulocyte colony-stimulating factor (G-CSF)
:*Also called granulocyte colony-stimulating factor (G-CSF)
:*Helps improve production of white blood cells
:*Helps improve production of white blood cells
 
*[[Pegfilgrastim]]
*Pegfilgrastim (Neulasta)
:*A long-acting G-CSF
:*A long-acting G-CSF
====Drug therapy====
====Supportive Therapy====
*Other drugs that may be used to treat symptoms or side effects of therapy include:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
*Other drugs that may be used to treat symptoms or side effects of therapy include:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
 
*[[Deferoxamine]]
*Deferoxamine (Desferal or DFO)
:*treats excess iron in the blood
:*treats excess iron in the blood
:*sometimes given with Vitamin C.
:*sometimes given with Vitamin C.
 
*[[Lenalidomide]]
*Lenalidomide (Revlimid)
:*decreases the need for transfusions in people with a specific chromosome change
:*decreases the need for transfusions in people with a specific chromosome change
 
*[[Antithymocyte globulin]]
*Antithymocyte globulin (ATG)
:*decreases the need for transfusions in certain types of myelodysplastic syndrome
:*decreases the need for transfusions in certain types of MDS
 
*Antibiotics
*Antibiotics
:*help to prevent or treat infections
:*help to prevent or treat infections
 
*Hypomethylating agents, such as [[5-azacytidine]] or [[decitabine]]
*Hypomethylating agents, such as 5-azacytidine or decitabine (Dacogen)
:*stop cancer cells from producing DNA or RNA so the cells die
:*stop cancer cells from producing DNA or RNA so the cells die
===Stem cell transplant===
A stem cell transplant may be a treatment option for younger people and those with high-risk MDS.<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
==References==
==References==
{{reflist|2}}
{{reflist|1}}


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Latest revision as of 02:49, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

Chemotherapy is recommended among all patients who develop myelodysplastic syndrome.[1]

Medical Therapy

  • Treatment is based on the type of myelodysplastic syndrome and the person's age and general health. The goal of treatment for myelodysplastic syndrome is to:[1]
    • Relieve symptoms
    • Slow or prevent progression of the disease
    • Improve quality of life

Chemotherapy

  • The most common chemotherapy drug used to treat myelodysplastic syndrome is cytarabine. Cytarabine may be combined with other pharmacological agents such as:[1]
  • Other chemotherapeutic agents that may be used to treat myelodysplastic syndrome include:[1]

Supportive Therapy

  • Supportive therapy is given to relieve symptoms and lessen the problems caused by abnormal blood cell counts or treatment for myelodysplastic syndrome.[1]

Transfusions

  • Patients with anemia may receive blood transfusions to correct the red blood cell counts.
  • Frequent blood transfusions can be complicated by a buildup of extra iron in the body, which is treated with drug therapy.
  • Patients with bleeding problems due to low platelet counts may be given platelet transfusions.

Growth Factors

  • Helps improve production of red blood cells
  • Also called granulocyte colony-stimulating factor (G-CSF)
  • Helps improve production of white blood cells
  • A long-acting G-CSF

Supportive Therapy

  • Other drugs that may be used to treat symptoms or side effects of therapy include:[1]
  • Deferoxamine
  • treats excess iron in the blood
  • sometimes given with Vitamin C.
  • decreases the need for transfusions in people with a specific chromosome change
  • decreases the need for transfusions in certain types of myelodysplastic syndrome
  • Antibiotics
  • help to prevent or treat infections
  • stop cancer cells from producing DNA or RNA so the cells die

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015


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