Natural killer cell deficiency: Difference between revisions
Jump to navigation
Jump to search
Rim Halaby (talk | contribs) (Created page with "__NOTOC__ {{CMG}} {{SK}} Classical NK cell deficiency, CNKD, functional NK cell deficiency, FNKD, NK cells deficiency syndrome, NK cell immunosuppression ==Overview== Natura...") |
Rim Halaby (talk | contribs) No edit summary |
||
| (7 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{CMG}} | {{SI}} | ||
{{CMG}}; {{AE}} {{Rim}}; {{YD}}; {{SSK}} | |||
{{SK}} Classical NK cell deficiency, CNKD, functional NK cell deficiency, FNKD, NK cells deficiency syndrome, NK cell immunosuppression | {{SK}} Classical NK cell deficiency, CNKD, CKND subtype 1, CNKD1, CKND subtype 2, CNKD2, functional NK cell deficiency, FNKD, FKND subtype 1, FKND1, NKD, NK cells deficiency syndrome, NK cell immunosuppression, Isolated NK cell deficiency, acquired NK cell deficiency, NK cell deficiency in AIDS | ||
==Overview== | ==Overview== | ||
Natural | Natural killer (NK) cells deficiency is a rare condition characterized by either the deficiency, absence, or malfunction of [[NK cell]]s, without the involvement of other types of immunological abnormalities and in the absence of secondary etiologies such as medications or viral infections.<ref name="pmid23993353">{{cite journal| author=Orange JS| title=Natural killer cell deficiency. | journal=J Allergy Clin Immunol | year= 2013 | volume= 132 | issue= 3 | pages= 515-25; quiz 526 | pmid=23993353 | doi=10.1016/j.jaci.2013.07.020 | pmc=PMC3917661 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23993353 }} </ref> NK cell deficiency is considered a type of [[immunosuppression]]. Acquired NK cells deficiency is not an uncommon finding among [[AIDS]] patients.<ref name="pmid2186744">{{cite journal| author=Sirianni MC, Tagliaferri F, Aiuti F| title=Pathogenesis of the natural killer cell deficiency in AIDS. | journal=Immunol Today | year= 1990 | volume= 11 | issue= 3 | pages= 81-2 | pmid=2186744 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2186744 }} </ref> | ||
==Classification== | ==Classification== | ||
* Classical NK cell deficiency (CNKD) | * Classical NK cell deficiency (CNKD): Absence of [[NK cell]]s in the peripheral blood | ||
* Functional NK cell deficiency (FNKD) | ** CKND subtype 1 | ||
** CKND subtype 2 | |||
* Functional NK cell deficiency (FNKD): Presence of [[NK cell]]s in the peripheral blood but with abnormal function | |||
**FKND subtype 1<ref name="pmid23993353">{{cite journal| author=Orange JS| title=Natural killer cell deficiency. | journal=J Allergy Clin Immunol | year= 2013 | volume= 132 | issue= 3 | pages= 515-25; quiz 526 | pmid=23993353 | doi=10.1016/j.jaci.2013.07.020 | pmc=PMC3917661 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23993353 }} </ref> | |||
==Causes== | |||
===Genes=== | |||
* GATA2 (CNKD1) | |||
* MCM4 (CNKD2) | |||
* FCGR3A (FNKD1)<ref name="pmid23993353">{{cite journal| author=Orange JS| title=Natural killer cell deficiency. | journal=J Allergy Clin Immunol | year= 2013 | volume= 132 | issue= 3 | pages= 515-25; quiz 526 | pmid=23993353 | doi=10.1016/j.jaci.2013.07.020 | pmc=PMC3917661 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23993353 }} </ref> | |||
==References== | ==References== | ||
Latest revision as of 22:06, 16 February 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]; Yazan Daaboul, M.D.; Serge Korjian M.D.
Synonyms and keywords: Classical NK cell deficiency, CNKD, CKND subtype 1, CNKD1, CKND subtype 2, CNKD2, functional NK cell deficiency, FNKD, FKND subtype 1, FKND1, NKD, NK cells deficiency syndrome, NK cell immunosuppression, Isolated NK cell deficiency, acquired NK cell deficiency, NK cell deficiency in AIDS
Overview
Natural killer (NK) cells deficiency is a rare condition characterized by either the deficiency, absence, or malfunction of NK cells, without the involvement of other types of immunological abnormalities and in the absence of secondary etiologies such as medications or viral infections.[1] NK cell deficiency is considered a type of immunosuppression. Acquired NK cells deficiency is not an uncommon finding among AIDS patients.[2]
Classification
- Classical NK cell deficiency (CNKD): Absence of NK cells in the peripheral blood
- CKND subtype 1
- CKND subtype 2
- Functional NK cell deficiency (FNKD): Presence of NK cells in the peripheral blood but with abnormal function
- FKND subtype 1[1]
Causes
Genes
- GATA2 (CNKD1)
- MCM4 (CNKD2)
- FCGR3A (FNKD1)[1]
References
- ↑ 1.0 1.1 1.2 Orange JS (2013). "Natural killer cell deficiency". J Allergy Clin Immunol. 132 (3): 515–25, quiz 526. doi:10.1016/j.jaci.2013.07.020. PMC 3917661. PMID 23993353.
- ↑ Sirianni MC, Tagliaferri F, Aiuti F (1990). "Pathogenesis of the natural killer cell deficiency in AIDS". Immunol Today. 11 (3): 81–2. PMID 2186744.