Acebutolol adverse reactions: Difference between revisions

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__NOTOC__
#redirect: [[Acebutolol#Adverse Reactions]]
{{Acebutolol}}
{{CMG}}; {{AE}} {{SS}}
 
==Adverse Reactions==
Sectral is well tolerated in properly selected patients. Most adverse reactions have been mild, not required discontinuation of therapy, and tended to decrease as duration of treatment increases.
 
The following table shows the frequency of treatment-related side effects derived from controlled clinical trials in patients with hypertension, angina pectoris, and arrhythmia. These patients received Sectral, propranolol, or hydrochlorothiazide as monotherapy, or placebo.
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The following selected (potentially important) side effects were seen in up to 2% of Sectral patients:
 
'''Cardiovascular''': [[hypotension]], [[bradycardia]], [[heart failure]].
 
'''Central Nervous System''': [[anxiety]], hyper/[[hypoesthesia]], [[impotence]].
 
'''Dermatological''': [[pruritus]].
 
'''Gastrointestinal''': [[vomiting]], [[abdominal pain]].
 
'''Genitourinary''': [[dysuria]], [[nocturia]].
 
'''Liver and Biliary System''': A small number of cases of liver abnormalities (increased SGOT, SGPT, LDH) have been reported in association with acebutolol therapy. In some cases increased bilirubin or alkaline phosphatase, fever, [[malaise]], [[dark urine]], [[anorexia]], [[nausea]], [[headache]], and/or other symptoms have been reported. In some of the reported cases, the symptoms and signs were confirmed by rechallenge with acebutolol. The abnormalities were reversible upon cessation of acebutolol therapy.
 
'''Musculoskeletal''': [[back pain]], [[joint pain]].
 
'''Respiratory''': [[pharyngitis]], [[wheezing]].
 
'''Special Senses''': [[conjunctivitis]], dry eye, eye pain.
 
'''Autoimmune''': In extremely rare instances, [[systemic lupus erythematosus]] has been reported.
 
The incidence of drug-related adverse effects (volunteered and solicited) according to Sectral dose is shown below. (Data from 266 [[hypertensive]] patients treated for 3 months on a constant dose.)
<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = SECTRAL (ACEBUTOLOL HYDROCHLORIDE) CAPSULE [PROMIUS PHARMA, LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7eee95bf-0452-4d6e-9712-33403768695a | publisher =  | date =  | accessdate = 3 February 2014 }}</ref>
 
 
 
==References==
 
{{Reflist|2}}
 
[[Category:Beta blockers]]
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]
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Latest revision as of 12:13, 21 July 2014