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| {{main|Valproic acid}}
| | #REDIRECT [[Valproate sodium]] |
| {{drugbox |
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| | IUPAC_name = sodium 2-propylpentanoate
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| | image = Sodium-valproate-2D-skeletal.png
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| | width=180
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| | CAS_number = 1069-66-5
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| | ATC_prefix = N03
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| | ATC_suffix = AG01
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| | PubChem = 14047
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| | DrugBank =
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| | C=8 | H=15 | Na=1 | O=2
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| | molecular_weight = 166.20 g/mol
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| | bioavailability =
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| | protein_bound = 90–95%
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| | metabolism = 75% by [[Cytochrome P450|CYP]] enzymes
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| | elimination_half-life = 9–18 hours
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| | excretion = 20% excreted as [[glucuronidation|glucuronide]]
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| | pregnancy_AU = D
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| | pregnancy_US = D
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| | legal_UK = POM
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| | legal_US = Rx-only
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| | routes_of_administration = Oral, [[Intravenous|i.v.]]
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| }}
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| '''Sodium valproate''' ([[International Nonproprietary Name|INN]]) or '''valproate sodium''' ([[USAN]]) is the sodium salt of [[valproic acid]] and is an [[anticonvulsant]] used in the treatment of [[epilepsy]] and [[bipolar disorder]], as well as other psychiatric conditions requiring the administration of a [[mood stabilizer]]. The [[intravenous therapy|intravenous]] formulations are used when oral administration is not possible.
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| ==Formulations==
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| Trade names are in '''bold''', followed by the manufacturer.
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| ===U.S.===
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| * Intravenous injection – '''Depacon''' by [[Abbott Laboratories]].
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| * Syrup – '''Depakene''' by [[Abbott Laboratories]]. (Note Depakene ''capsules'' are valproic acid).
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| ===UK and Australia===
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| * Tablets – '''Orlept''' by Wockhardt and '''Epilim''' by [[Sanofi-Aventis]].
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| * Oral solution – '''Orlept Sugar Free''' by Wockhardt and '''Epilim''' by Sanofi-Aventis.
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| * Syrup – '''Epilim''' by Sanofi-Aventis.
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| * Intravenous injection – '''Epilim''' '''Intravenous''' by Sanofi-Aventis.
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| * Extended release tablets – '''Epilim Chrono''' by Sanofi-Aventis. A combination of sodium valproate and valproic acid in a 2.3:1 ratio.
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| * Enteric-coated tablets – '''Epilim EC200''' by Sanofi-synthélabo. A 200 mg sodium valproate [[Enteric coating|enteric-coated]] tablet.
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| ===Germany, Switzerland, Norway===
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| * Tablets – '''Orfiril''' by Desitin Pharmaceuticals
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| * Intravenous injection – '''Orfiril IV''' by Desitin Pharmaceuticals
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| ===South Africa===
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| * Syrup – '''Convulex''' by Byk Madaus
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| ===Canada===
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| * Intravenous injection – '''Epival''' or '''Epiject''' by [[Abbott Laboratories]].
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| * Syrup – '''Depakene''' by [[Abbott Laboratories]]. Generic formulations include [http://www.apotex.ca/Products/EN/Detail.asp?MaterialNumber=000000000000042290 Apo-Valproic] and [http://www.ratiopharm.ca/e/Products/productSearch.asp?Cap=V ratio-Valproic].
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| ===Others===
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| In much of Europe, '''Depakine''' and '''Depakine Chrono''' are equivalent to Epilim and Epilim Chrono above.
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| ==See also==
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| * [[Valproate semisodium]]
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| ==External links==
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| * [http://www.chemicalland21.com/lifescience/phar/SODIUM%20VALPORATE.htm Chemical Land21: Sodium Valproate]
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| * [http://www.rxlist.com/cgi/generic/valproate.htm RXList.com: Depacon (Sodium Valproate)]
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| * [http://www.bnf.org/bnf/bnf/current/noframes/index.htm British National Formulary Edition 50]
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| * [http://www.medbroadcast.com/drug_info_details.asp?brand_name_id=547 Med Broadcast.com: Epival]
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| * [http://www.drugs.com/PDR/Depakene_Syrup.html Drugs.com: Depaken Syrup]
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| {{Anticonvulsants}}
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| [[Category:Anticonvulsants]]
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| [[Category:Mood stabilizers]]
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| [[Category:Teratogens]]
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| {{WikiDoc Sources}}
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