Cycloserine warnings and precautions: Difference between revisions
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==Warnings== | |||
Administration of Seromycin should be discontinued or the dosage reduced if the patient develops [[allergic dermatitis]] or symptoms of CNS toxicity, such as [[convulsions]], [[psychosis]], [[somnolence]], [[depression]], [[confusion]], [[hyperreflexia]], [[headache]], [[tremor]], [[vertigo]], [[paresis]], or [[dysarthria]]. | |||
The toxicity of Seromycin is closely related to excessive blood levels (above 30 μg/mL), as determined by high dosage or inadequate renal clearance. The ratio of toxic dose to effective dose in tuberculosis is small. | |||
The risk of convulsions is increased in chronic alcoholics. | |||
Patients should be monitored by hematologic, renal excretion, blood level, and liver function studies.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = SEROMYCIN (CYCLOSERINE) CAPSULE [PURDUE GMP CENTER LLC DBA THE CHAO CENTER] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e1e08327-4b90-463e-bb2a-22438cabcef2 | publisher = | date = | accessdate }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 02:38, 31 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
Warnings
Administration of Seromycin should be discontinued or the dosage reduced if the patient develops allergic dermatitis or symptoms of CNS toxicity, such as convulsions, psychosis, somnolence, depression, confusion, hyperreflexia, headache, tremor, vertigo, paresis, or dysarthria.
The toxicity of Seromycin is closely related to excessive blood levels (above 30 μg/mL), as determined by high dosage or inadequate renal clearance. The ratio of toxic dose to effective dose in tuberculosis is small.
The risk of convulsions is increased in chronic alcoholics.
Patients should be monitored by hematologic, renal excretion, blood level, and liver function studies.[1]
References
- ↑ "SEROMYCIN (CYCLOSERINE) CAPSULE [PURDUE GMP CENTER LLC DBA THE CHAO CENTER]". Text " accessdate " ignored (help)
Adapted from the FDA Package Insert.