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|+ '''Manifestations of Lyme Disease by Stage<ref name="Steere-1989">{{Cite journal  | last1 = Steere | first1 = AC. | title = Lyme disease. | journal = N Engl J Med | volume = 321 | issue = 9 | pages = 586-96 | month = Aug | year = 1989 | doi = 10.1056/NEJM198908313210906 |PMID = 2668764 }}</ref>'''
|-
|-
| System||Stage 1 (Localized)||Stage 2 (Disseminated)||Stage 3 (Persistent)
| '''System''' || '''Stage 1 (Localized Infection)''' || '''Stage 2 (Disseminated Infection)''' || '''Stage 3 (Persistent Infection)'''
|-
|-
| Skin||Erythema migrans||Secondary annular lesions ||Acrodermatitis chronica atrophicans
| ''Skin'' ||valign="top"| ▸ Erythema migrans ||valign="top"| ▸ Secondary annular lesions <BR> ▸ Malar rash <BR> ▸ Diffuse erythema or urticaria <BR> ▸ Evanescent lesions <BR> ▸ Lymphocytoma ||valign="top"| ▸ Acrodermatitis chronica atrophicans <BR> ▸ Localized scleroderma-like lesions
 
|-
|-
| ||||Malar rash||Localized scleroderma-like lesions
| ''Musculoskeletal'' || ||valign="top"| ▸ Migratory arthralgia <BR> ▸ Brief arthritis attacks <BR> ▸ Myositis <BR> ▸ Osteomyelitis <BR> ▸ Panniculitis ||valign="top"| ▸ Prolonged arthritis attacks <BR> ▸ Chronic arthritis <BR> ▸ Peripheral enthesopathy <BR> ▸ Periostitis or joint subluxations below acrodermatitis
|-
|-
| ||||Diffuse erythema or urticaria||
| ''Neurologic'' || ||valign="top"| ▸ Meningitis <BR> ▸ Cranial neuritis or Bell's palsy <BR> ▸ Motor or sensory radiculoneuritis <BR> ▸ Encephalitis <BR> ▸ Mononeuritis multiplex <BR> ▸ Pseudotumor cerebri <BR> ▸ Myelitis <BR> ▸ Chorea <BR> ▸ Cerebellar ataxia||valign="top"| ▸ Chronic encephalomyelitis <BR> ▸ Spastic parapareses <BR> ▸ Ataxic gait <BR> ▸ Mental disorders <BR> ▸ Chronic axonal polyradiculopathy <BR> ▸ Dementia
|-
|-
| ||||Evanescent lesions||
| ''Lymphatic'' ||valign="top"| ▸ Regional lymphadenopathy ||valign="top"| ▸ Regional or generalized lymphadenopathy <BR> ▸ Splenomegaly ||
|-
|-
| ||||Lymphocytoma||
| ''Heart'' || ||valign="top"| ▸ Atrioventricular nodal block <BR> ▸ Myopericarditis <BR> ▸ Pancarditis ||
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|-
| Musculoskeletal||||Migratory arthralgia||Prolonged arthritis attacks
| ''Eyes'' || ||valign="top"| ▸ Conjunctivitis <BR> ▸ Iritis <BR> ▸ Choroiditis Panophthalmitis <BR> ▸ Retinal hemorrhage or detachment <BR> ▸ Panophthalmitis ||valign="top"| ▸ Keratitis
 
 
 
 
 
 
 
|-
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| ||||Brief arthritis attacks||Chronic arthritis
| ''Liver'' || || ▸ Mild or recurrent hepatitis ||
|-
|-
| ||||Myositis||Peripheral enthesopathy
| ''Respiratory'' || ||valign="top"| ▸ Nonexudative sore throat <BR> ▸ Nonproductive cough <BR> ▸ Adult respiratory distress syndrome ||
|-
|-
| ||||Osteomyelitis||Periostitis or joint subluxations below acrodermatitis
| ''Kidney'' || ||valign="top"| ▸ Microscopic hematuria or proteinuria ||
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|-
| ||||Panniculitis||
| ''Genitourinary'' || || ▸ Orchitis ||
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|-
| Neurologic||||Meningitis||Chronic encephalomyelitis
| ''Constitutional systems'' || ▸ Minor || ▸ Severe malaise and fatigue || ▸ Fatigue
|-
| ||||Cranial neuritis or Bell's palsy||Spastic parapareses
|-
| ||||Motor or sensory radiculoneuritis||Ataxic gait
|-
| ||||Encephalitis||Mental disorders
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| ||||Mononeuritis multiplex||Chronic axonal polyradiculopathy
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| ||||Pseudotumor cerebri||Dementia
|-
| ||||Myelitis||
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| ||||Chorea||
|-
| ||||Cerebellar ataxia||
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| Lymphatic||Regional lymphadenopathy||Regional or generalized lymphadenopathy||
|-
| ||||Splenomegaly||
|-
| Heart||||Atrioventricular nodal block||
|-
| ||||Myopericarditis||
|-
| ||||Pancarditis||
|-
| Eyes||||Conjunctivitis||Keratitis
|-
| ||||Iritis||
|-
| ||||Choroiditis||
|-
| ||||Retinal hemorrhage or detachment||
|-
| ||||Panophthalmitis||
|-
| Liver||||Mild or recurrent hepatitis||
|-
| Respiratory||||Nonexudative sore throat||
|-
| ||||Nonproductive cough||
|-
| ||||Adult respiratory distress syndrome||
|-
| Kidney||||Microscopic hematuria or proteinuria||
|-
| Genitourinary||||Orchitis||
|-
| Constitutional systems||Minor||Severe malaise and fatigue||Fatigue
|}
|}

Revision as of 20:00, 13 December 2013





Manifestations of Lyme Disease by Stage[1]
System Stage 1 (Localized Infection) Stage 2 (Disseminated Infection) Stage 3 (Persistent Infection)
Skin ▸ Erythema migrans ▸ Secondary annular lesions
▸ Malar rash
▸ Diffuse erythema or urticaria
▸ Evanescent lesions
▸ Lymphocytoma		 ▸ Acrodermatitis chronica atrophicans
▸ Localized scleroderma-like lesions
Musculoskeletal ▸ Migratory arthralgia
▸ Brief arthritis attacks
▸ Myositis
▸ Osteomyelitis
▸ Panniculitis		 ▸ Prolonged arthritis attacks
▸ Chronic arthritis
▸ Peripheral enthesopathy
▸ Periostitis or joint subluxations below acrodermatitis
Neurologic ▸ Meningitis
▸ Cranial neuritis or Bell's palsy
▸ Motor or sensory radiculoneuritis
▸ Encephalitis
▸ Mononeuritis multiplex
▸ Pseudotumor cerebri
▸ Myelitis
▸ Chorea
▸ Cerebellar ataxia		 ▸ Chronic encephalomyelitis
▸ Spastic parapareses
▸ Ataxic gait
▸ Mental disorders
▸ Chronic axonal polyradiculopathy
▸ Dementia
Lymphatic ▸ Regional lymphadenopathy ▸ Regional or generalized lymphadenopathy
▸ Splenomegaly
Heart ▸ Atrioventricular nodal block
▸ Myopericarditis
▸ Pancarditis
Eyes ▸ Conjunctivitis
▸ Iritis
▸ Choroiditis Panophthalmitis
▸ Retinal hemorrhage or detachment
▸ Panophthalmitis		 ▸ Keratitis




Liver ▸ Mild or recurrent hepatitis
Respiratory ▸ Nonexudative sore throat
▸ Nonproductive cough
▸ Adult respiratory distress syndrome
Kidney ▸ Microscopic hematuria or proteinuria
Genitourinary ▸ Orchitis
Constitutional systems ▸ Minor ▸ Severe malaise and fatigue ▸ Fatigue
  1. ↑ Steere, AC. (1989). "Lyme disease". N Engl J Med. 321 (9): 586–96. doi:10.1056/NEJM198908313210906. PMID 2668764. Unknown parameter |month= ignored (help)
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