Isolated nonketotic hyperglycinemia: Difference between revisions

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(Created page with "__NOTOC__ {{SI}} {{CMG}} {{SK}} Glycine encephalopathy; glycine synthase deficiency. ==Overview== Isolated non ketotic hyperglycinemia with is relatively frequent among inbo...")
 
(Replaced content with "#redirect:D-Glyceric acidemia")
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__NOTOC__
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{{SI}}
{{CMG}}


{{SK}} Glycine encephalopathy; glycine synthase deficiency.
D-Glyceric acidemia]]
==Overview==
 
Isolated non ketotic hyperglycinemia with is relatively frequent among inborn errors of newborns. It is transmitted as an [[autosomal recessive]] trait. It affects hepatic glycine cleavage, which is the main source of monocarbon radicals. Onset is generally neonatal with [[coma]], severe [[ hypotonia]], [[myoclonic seizures]], and [[microcephaly]]. The disease usually progresses to severe mental retardation and tetrapyramidal syndrome. The [[ electroencephalogram]] yields a characteristic hypoactive and pseudoperiodic chart with burts suppression. Biological findings are massive levels of glycine in plasma, urine, and especially cephalospinal fluid, while serine is low. The diagnosis is confirmed by measuring enzymatic activity in the [[liver]]. A few cases with later onset have been described (patients present with aspecific encephalopathy), as well as transient neonatal cases, which first present with a favourable disease course, whose long term outcome is finally disappointing. Treatment is based on [[sodium benzoate]] and [[dextromethorphane]], but its efficiency has not been demonstrated. Genes encoding N or P subunit may carry different mutations. Antenatal diagnosis using a [[chorion villus sample]] may be performed by studying glycine cleavage (not reliable method) or by gene analysis if the mutation is known
 
==References==
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Revision as of 23:07, 9 October 2012

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D-Glyceric acidemia]]