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| {{Infobox Disease
| | #Redirect[[Hemolytic anemia differential diagnosis]] |
| | Name = {{PAGENAME}}
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| | Image =
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| | DiseasesDB =
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| | ICD10 = {{ICD10|D|59|0|d|55}}
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| | ICD9 = {{ICD9|283}}
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| | OMIM =
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| | MedlinePlus =
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| | eMedicineSubj =
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| | MeshID =
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| {{SI}}
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| {{CMG}}
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| {{EH}}
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| ==Overview==
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| '''Drug-induced autoimmune hemolytic anaemia''' is a form of [[hemolytic anaemia]].
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| ==Differential diagnosis of underlying causes==
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| [[Penicillin]] in high doses can induce immune mediated [[hemolysis]]<ref name="pmid10815791">{{cite journal |author=Stroncek D, Procter JL, Johnson J |title=Drug-induced hemolysis: cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction |journal=Am. J. Hematol. |volume=64 |issue=1 |pages=67–70 |year=2000 |month=May |pmid=10815791 |doi= |url=http://dx.doi.org/10.1002/(SICI)1096-8652(200005)64:1<67::AID-AJH12>3.0.CO;2-Z}}</ref> via the [[hapten]] mechanism in which antibodies are targeted against the combination of penicillin in association with red blood cells. Complement is activated by the attached antibody leading to the removal of red blood cells by the spleen.
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| The drug itself can be targeted by the immune system, e.g. by [[IgE]] in a [[Type I hypersensitivity reaction]] to penicillin, rarely leading to anaphylaxis.
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| ==References==
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| {{reflist|2}}
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| {{Hematology}}
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| {{SIB}}
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| [[Category:Blood disorders]]
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| [[Category:Hematology]]
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| {{WH}}
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| {{WS}}
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