YWHAB

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
File:PBB Protein YWHAB image.jpg PDB rendering based on 2bq0.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2bq0​, 2c23​
Identifiers
Symbols	YWHAB ; HS1; GW128; KCIP-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20724
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE YWHAB 208743 s at tn.png
File:PBB GE YWHAB 217717 s at tn.png
File:PBB GE YWHAB 217718 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide, also known as YWHAB, is a human gene.

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.

See also

• 14-3-3 proteins

Further reading

• Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
• Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780.
• Calinisan V, Gravem D, Chen RP; et al. (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium". Front. Biosci. 11: 1646–66. PMID 16368544.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)