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Revision as of 16:02, 6 September 2012


Yes-associated protein 1, 65kDa
File:PBB Protein YAP1 image.jpg
PDB rendering based on 1jmq.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols YAP1 ; YAP; YAP2; YAP65
External IDs Template:OMIM5 Template:MGI HomoloGene: 4452
RNA expression pattern
File:PBB GE YAP1 213342 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Yes-associated protein 1, 65kDa, also known as YAP1, is a human gene.[1]

This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: YAP1 Yes-associated protein 1, 65kDa".

Further reading

  • Sudol M, Chen HI, Bougeret C; et al. (1995). "Characterization of a novel protein-binding module--the WW domain". FEBS Lett. 369 (1): 67–71. PMID 7641887.
  • Chen HI, Sudol M (1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7819–23. PMID 7644498.
  • Sudol M, Bork P, Einbond A; et al. (1995). "Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain". J. Biol. Chem. 270 (24): 14733–41. PMID 7782338.
  • Chen HI, Einbond A, Kwak SJ; et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands". J. Biol. Chem. 272 (27): 17070–7. PMID 9202023.
  • Gavva NR, Gavva R, Ermekova K; et al. (1997). "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II". J. Biol. Chem. 272 (39): 24105–8. PMID 9305852.
  • Yagi R, Chen LF, Shigesada K; et al. (1999). "A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator". EMBO J. 18 (9): 2551–62. doi:10.1093/emboj/18.9.2551. PMID 10228168.
  • Mohler PJ, Kreda SM, Boucher RC; et al. (1999). "Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50". J. Cell Biol. 147 (4): 879–90. PMID 10562288.
  • Espanel X, Sudol M (2001). "Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains". J. Biol. Chem. 276 (17): 14514–23. doi:10.1074/jbc.M008568200. PMID 11278422.
  • Strano S, Munarriz E, Rossi M; et al. (2001). "Physical interaction with Yes-associated protein enhances p73 transcriptional activity". J. Biol. Chem. 276 (18): 15164–73. doi:10.1074/jbc.M010484200. PMID 11278685.
  • Vassilev A, Kaneko KJ, Shu H; et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMID 11358867.
  • Pires JR, Taha-Nejad F, Toepert F; et al. (2002). "Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope". J. Mol. Biol. 314 (5): 1147–56. doi:10.1006/jmbi.2000.5199. PMID 11743730.
  • Ferrigno O, Lallemand F, Verrecchia F; et al. (2002). "Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling". Oncogene. 21 (32): 4879–84. doi:10.1038/sj.onc.1205623. PMID 12118366.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Basu S, Totty NF, Irwin MS; et al. (2003). "Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis". Mol. Cell. 11 (1): 11–23. PMID 12535517.
  • Komuro A, Nagai M, Navin NE, Sudol M (2003). "WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus". J. Biol. Chem. 278 (35): 33334–41. doi:10.1074/jbc.M305597200. PMID 12807903.
  • Omerovic J, Puggioni EM, Napoletano S; et al. (2004). "Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level". Exp. Cell Res. 294 (2): 469–79. doi:10.1016/j.yexcr.2003.12.002. PMID 15023535.
  • Howell M, Borchers C, Milgram SL (2004). "Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription". J. Biol. Chem. 279 (25): 26300–6. doi:10.1074/jbc.M401070200. PMID 15096513.
  • Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
  • Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Levy D, Adamovich Y, Reuven N, Shaul Y. (2007). "The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73". Cell Death and Differentiation. 14 (4): 743–51. doi:10.1038/sj.cdd.4402063. PMID 17110958.

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