VAMP1: Difference between revisions
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Revision as of 15:47, 6 September 2012
Vesicle-associated membrane protein 1 (synaptobrevin 1) | |||||||||||||
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File:PBB Protein VAMP1 image.jpg PDB rendering based on 1kil. | |||||||||||||
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Identifiers | |||||||||||||
Symbols | VAMP1 ; DKFZp686H12131; SYB1; VAMP-1 | ||||||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 40678 | ||||||||||||
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RNA expression pattern | |||||||||||||
File:PBB GE VAMP1 207101 at tn.png | |||||||||||||
File:PBB GE VAMP1 213326 at tn.png | |||||||||||||
File:PBB GE VAMP1 207100 s at tn.png | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Template:GNF Ortholog box | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | n/a | n/a | |||||||||||
Ensembl | n/a | n/a | |||||||||||
UniProt | n/a | n/a | |||||||||||
RefSeq (mRNA) | n/a | n/a | |||||||||||
RefSeq (protein) | n/a | n/a | |||||||||||
Location (UCSC) | n/a | n/a | |||||||||||
PubMed search | n/a | n/a |
Vesicle-associated membrane protein 1 (synaptobrevin 1), also known as VAMP1, is a human gene.[1]
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.[1]
References
Further reading
- Archer BT, Ozçelik T, Jahn R; et al. (1990). "Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2". J. Biol. Chem. 265 (28): 17267–73. PMID 1976629.
- Ravichandran V, Chawla A, Roche PA (1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. 271 (23): 13300–3. PMID 8663154.
- Jagadish MN, Fernandez CS, Hewish DR; et al. (1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2". Biochem. J. 317 ( Pt 3): 945–54. PMID 8760387.
- Annaert WG, Becker B, Kistner U; et al. (1998). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31". J. Cell Biol. 139 (6): 1397–410. PMID 9396746.
- Weir ML, Klip A, Trimble WS (1998). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP". Biochem. J. 333 ( Pt 2): 247–51. PMID 9657962.
- Isenmann S, Khew-Goodall Y, Gamble J; et al. (1999). "A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal". Mol. Biol. Cell. 9 (7): 1649–60. PMID 9658161.
- Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.
- Berglund L, Hoffmann HJ, Dahl R, Petersen TE (1999). "VAMP-1 has a highly variable C-terminus generated by alternative splicing". Biochem. Biophys. Res. Commun. 264 (3): 777–80. doi:10.1006/bbrc.1999.1588. PMID 10544008.
- Pérez-Brangulí F, Muhaisen A, Blasi J (2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Mol. Cell. Neurosci. 20 (2): 169–80. PMID 12093152.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Imabayashi H, Mori T, Gojo S; et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. PMID 12878157.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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