RAD51C

RAD51 homolog C (S. cerevisiae)
Identifiers
Symbols	RAD51C ; MGC104277; RAD51L2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 14238
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RAD51C 206066 s at tn.png
File:PBB GE RAD51C 209849 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

RAD51 homolog C (S. cerevisiae), also known as RAD51C, is a human gene.

This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified.

Further reading

• Dosanjh MK, Collins DW, Fan W; et al. (1998). "Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes". Nucleic Acids Res. 26 (5): 1179–84. PMID 9469824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schild D, Lio YC, Collins DW; et al. (2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs". J. Biol. Chem. 275 (22): 16443–9. doi:10.1074/jbc.M001473200. PMID 10749867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Avela K, Lipsanen-Nyman M, Idänheimo N; et al. (2000). "Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism". Nat. Genet. 25 (3): 298–301. doi:10.1038/77053. PMID 10888877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bärlund M, Monni O, Kononen J; et al. (2000). "Multiple genes at 17q23 undergo amplification and overexpression in breast cancer". Cancer Res. 60 (19): 5340–4. PMID 11034067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu GJ, Sinclair CS, Paape J; et al. (2000). "17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes". Cancer Res. 60 (19): 5371–5. PMID 11034073.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kurumizaka H, Ikawa S, Nakada M; et al. (2001). "Homologous-pairing activity of the human DNA-repair proteins Xrcc3.Rad51C". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5538–43. doi:10.1073/pnas.091603098. PMID 11331762.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leasure CS, Chandler J, Gilbert DJ; et al. (2001). "Sequence, chromosomal location and expression analysis of the murine homologue of human RAD51L2/RAD51C". Gene. 271 (1): 59–67. PMID 11410366.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masson JY, Stasiak AZ, Stasiak A; et al. (2001). "Complex formation by the human RAD51C and XRCC3 recombination repair proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (15): 8440–6. doi:10.1073/pnas.111005698. PMID 11459987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miller KA, Yoshikawa DM, McConnell IR; et al. (2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masson JY, Tarsounas MC, Stasiak AZ; et al. (2002). "Identification and purification of two distinct complexes containing the five RAD51 paralogs". Genes Dev. 15 (24): 3296–307. doi:10.1101/gad.947001. PMID 11751635.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sigurdsson S, Van Komen S, Bussen W; et al. (2002). "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange". Genes Dev. 15 (24): 3308–18. doi:10.1101/gad.935501. PMID 11751636.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiese C, Collins DW, Albala JS; et al. (2002). "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells". Nucleic Acids Res. 30 (4): 1001–8. PMID 11842112.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu N, Schild D, Thelen MP, Thompson LH (2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. 30 (4): 1009–15. PMID 11842113.CS1 maint: Multiple names: authors list (link)
• Godthelp BC, Artwert F, Joenje H, Zdzienicka MZ (2002). "Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1". Oncogene. 21 (32): 5002–5. doi:10.1038/sj.onc.1205656. PMID 12118380.CS1 maint: Multiple names: authors list (link)
• Lio YC, Mazin AV, Kowalczykowski SC, Chen DJ (2003). "Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro". J. Biol. Chem. 278 (4): 2469–78. doi:10.1074/jbc.M211038200. PMID 12427746.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• French CA, Tambini CE, Thacker J (2003). "Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion". J. Biol. Chem. 278 (46): 45445–50. doi:10.1074/jbc.M308621200. PMID 12966089.CS1 maint: Multiple names: authors list (link)
• Braybrooke JP, Li JL, Wu L; et al. (2004). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". J. Biol. Chem. 278 (48): 48357–66. doi:10.1074/jbc.M308838200. PMID 12975363.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miller KA, Sawicka D, Barsky D, Albala JS (2004). "Domain mapping of the Rad51 paralog protein complexes". Nucleic Acids Res. 32 (1): 169–78. doi:10.1093/nar/gkg925. PMID 14704354.CS1 maint: Multiple names: authors list (link)
• Liu Y, Masson JY, Shah R; et al. (2004). "RAD51C is required for Holliday junction processing in mammalian cells". Science. 303 (5655): 243–6. doi:10.1126/science.1093037. PMID 14716019.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)