PTPN7

Protein tyrosine phosphatase, non-receptor type 7
File:PBB Protein PTPN7 image.jpg PDB rendering based on 1zc0.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1zc0​, 2a3k​, 2gp0​
Identifiers
Symbols	PTPN7 ; BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI
External IDs	Template:OMIM5 Template:MGI HomoloGene: 15411
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PTPN7 204852 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, non-receptor type 7, also known as PTPN7, is a human gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Further reading

• Adachi M, Sekiya M, Arimura Y; et al. (1992). "Protein-tyrosine phosphatase expression in pre-B cell NALM-6". Cancer Res. 52 (3): 737–40. PMID 1370651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adachi M, Sekiya M, Isobe M; et al. (1992). "Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP". Biochem. Biophys. Res. Commun. 186 (3): 1607–15. PMID 1510684.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zanke B, Suzuki H, Kishihara K; et al. (1992). "Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase)". Eur. J. Immunol. 22 (1): 235–9. PMID 1530918.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Swieter M, Berenstein EH, Swaim WD, Siraganian RP (1995). "Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP". J. Biol. Chem. 270 (37): 21902–6. PMID 7545170.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Zanke B, Squire J, Griesser H; et al. (1994). "A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1". Leukemia. 8 (2): 236–44. PMID 8309248.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saxena M, Williams S, Gilman J, Mustelin T (1998). "Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. 273 (25): 15340–4. PMID 9624114.CS1 maint: Multiple names: authors list (link)
• Saxena M, Williams S, Brockdorff J; et al. (1999). "Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. 274 (17): 11693–700. PMID 10206983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oh-hora M, Ogata M, Mori Y; et al. (1999). "Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase". J. Immunol. 163 (3): 1282–8. PMID 10415025.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saxena M, Williams S, Taskén K, Mustelin T (1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase". Nat. Cell Biol. 1 (5): 305–11. doi:10.1038/13024. PMID 10559944.CS1 maint: Multiple names: authors list (link)
• Pettiford SM, Herbst R (2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene. 19 (7): 858–69. doi:10.1038/sj.onc.1203408. PMID 10702794.
• Gjörloff-Wingren A, Saxena M, Han S; et al. (2000). "Subcellular localization of intracellular protein tyrosine phosphatases in T cells". Eur. J. Immunol. 30 (8): 2412–21. PMID 10940933.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tartaglia M, Mehler EL, Goldberg R; et al. (2001). "Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome". Nat. Genet. 29 (4): 465–8. doi:10.1038/ng772. PMID 11704759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang ZX, Zhou B, Wang QM, Zhang ZY (2002). "A kinetic approach for the study of protein phosphatase-catalyzed regulation of protein kinase activity". Biochemistry. 41 (24): 7849–57. PMID 12056917.CS1 maint: Multiple names: authors list (link)
• Digilio MC, Conti E, Sarkozy A; et al. (2002). "Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene". Am. J. Hum. Genet. 71 (2): 389–94. PMID 12058348.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kosaki K, Suzuki T, Muroya K; et al. (2002). "PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome". J. Clin. Endocrinol. Metab. 87 (8): 3529–33. PMID 12161469.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pettiford SM, Herbst R (2003). "The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells". Leukemia. 17 (2): 366–78. doi:10.1038/sj.leu.2402767. PMID 12592337.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)