PRB1

Proline-rich protein BstNI subfamily 1
Identifiers
Symbols	PRB1 ; PM; PMF; PMS; PRB1L; PRB1M; Ps 1; Ps 2; PRPPRB1; Ps; cP7
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74537
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PRB1 207752 x at tn.png
File:PBB GE PRB1 216881 x at tn.png
File:PBB GE PRB1 210597 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Proline-rich protein BstNI subfamily 1, also known as PRB1, is a human gene.

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Further reading

• Azen EA, Maeda N (1988). "Molecular genetics of human salivary proteins and their polymorphisms". Adv. Hum. Genet. 17: 141–99. PMID 3055850.
• Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. PMID 6810092.
• Ikemoto S, Minaguchi K, Suzuki K, Tomita K (1977). "New Genetic marker in human parotid saliva (pm)". Science. 197 (4301): 378–9. PMID 877561.CS1 maint: Multiple names: authors list (link)
• Castle AM, Stahl LE, Castle JD (1992). "A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum". J. Biol. Chem. 267 (18): 13093–100. PMID 1618808.CS1 maint: Multiple names: authors list (link)
• Lyons KM, Stein JH, Smithies O (1989). "Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over". Genetics. 120 (1): 267–78. PMID 2851479.CS1 maint: Multiple names: authors list (link)
• Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. PMID 2993301.CS1 maint: Multiple names: authors list (link)
• Kauffman D, Hofmann T, Bennick A, Keller P (1986). "Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6". Biochemistry. 25 (9): 2387–92. PMID 3521730.CS1 maint: Multiple names: authors list (link)
• Azen E, Lyons KM, McGonigal T; et al. (1984). "Clones from the human gene complex coding for salivary proline-rich proteins". Proc. Natl. Acad. Sci. U.S.A. 81 (17): 5561–5. PMID 6089212.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saitoh E, Isemura S, Sanada K (1984). "Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H". J. Biochem. 94 (6): 1991–9. PMID 6671974.CS1 maint: Multiple names: authors list (link)
• Kauffman D, Wong R, Bennick A, Keller P (1983). "Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair". Biochemistry. 21 (25): 6558–62. PMID 6924859.CS1 maint: Multiple names: authors list (link)
• Isemura S, Saitoh E, Sanada K (1982). "Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E". J. Biochem. 91 (6): 2067–75. PMID 7118863.CS1 maint: Multiple names: authors list (link)
• Azen EA, Latreille P, Niece RL (1993). "PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs)". Am. J. Hum. Genet. 53 (1): 264–78. PMID 8317492.CS1 maint: Multiple names: authors list (link)
• Kim HS, Lyons KM, Saitoh E; et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. PMID 8422499.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Castle AM, Castle JD (1998). "Enhanced glycosylation and sulfation of secretory proteoglycans is coupled to the expression of a basic secretory protein". Mol. Biol. Cell. 9 (3): 575–83. PMID 9487127.
• Harrington JJ, Sherf B, Rundlett S; et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. PMID 11422372.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)