LCP1

Lymphocyte cytosolic protein 1 (L-plastin)
File:PBB Protein LCP1 image.jpg PDB rendering based on 2d85.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2d85​
Identifiers
Symbols	LCP1 ; CP64; DKFZp781A23186; FLJ25423; FLJ26114; FLJ39956; L-PLASTIN; LC64P; PLS2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 80174
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LCP1 208885 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Lymphocyte cytosolic protein 1 (L-plastin), also known as LCP1, is a human gene.

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

Further reading

• Namba Y, Ito M, Zu Y; et al. (1993). "Human T cell L-plastin bundles actin filaments in a calcium-dependent manner". J. Biochem. 112 (4): 503–7. PMID 1491005.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zu Y, Kohno M, Kubota I; et al. (1990). "Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells". Biochemistry. 29 (4): 1055–62. PMID 2111166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zu YL, Shigesada K, Nishida E; et al. (1991). "65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites". Biochemistry. 29 (36): 8319–24. PMID 2252891.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin CS, Aebersold RH, Leavitt J (1990). "Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain". Mol. Cell. Biol. 10 (4): 1818–21. PMID 2378651.CS1 maint: Multiple names: authors list (link)
• Lin CS, Aebersold RH, Kent SB; et al. (1989). "Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts". Mol. Cell. Biol. 8 (11): 4659–68. PMID 3211125.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsushima K, Shiroo M, Kung HF, Copeland TD (1988). "Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1". Biochemistry. 27 (10): 3765–70. PMID 3261603.CS1 maint: Multiple names: authors list (link)
• Kondo I, Shin K, Honmura S; et al. (1986). "A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13". Hum. Genet. 71 (3): 263–6. PMID 3864729.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arpin M, Friederich E, Algrain M; et al. (1995). "Functional differences between L- and T-plastin isoforms". J. Cell Biol. 127 (6 Pt 2): 1995–2008. PMID 7806577.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Lin CS, Shen W, Chen ZP; et al. (1994). "Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney". Mol. Cell. Biol. 14 (4): 2457–67. PMID 8139549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin CS, Park T, Chen ZP, Leavitt J (1993). "Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells". J. Biol. Chem. 268 (4): 2781–92. PMID 8428952.CS1 maint: Multiple names: authors list (link)
• Lin CS, Chen ZP, Park T; et al. (1993). "Characterization of the human L-plastin gene promoter in normal and neoplastic cells". J. Biol. Chem. 268 (4): 2793–801. PMID 8428953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jones SL, Brown EJ (1996). "FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils". J. Biol. Chem. 271 (24): 14623–30. PMID 8663066.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okumura Y, Yano M, Murakami M; et al. (1999). "The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin". FEBS Lett. 442 (1): 39–42. PMID 9923600.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang J, Brown EJ (1999). "Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A.". J. Biol. Chem. 274 (34): 24349–56. PMID 10446213.
• Lin CS, Lau A, Yeh CC; et al. (2000). "Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences". DNA Cell Biol. 19 (1): 1–7. doi:10.1089/104454900314654. PMID 10668786.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jia J, Han Q, Borregaard N; et al. (2000). "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family". J. Mol. Biol. 300 (5): 1271–81. doi:10.1006/jmbi.2000.3925. PMID 10903868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lollike K, Johnsen AH, Durussel I; et al. (2001). "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner". J. Biol. Chem. 276 (21): 17762–9. doi:10.1074/jbc.M100965200. PMID 11279160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki H, Fukunishi Y, Kagawa I; et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)