HABP2

Hyaluronan binding protein 2
Identifiers
Symbols	HABP2 ; FSAP; HABP; HGFAL; PHBP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3050
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Hyaluronan binding protein 2, also known as HABP2, is a human gene.

The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion. The protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. Two transcript variants utilizing alternative polyA sites exist for this gene.

Further reading

• Römisch J (2003). "Factor VII activating protease (FSAP): a novel protease in hemostasis". Biol. Chem. 383 (7–8): 1119–24. PMID 12437095.
• Gupta S, Batchu RB, Datta K (1992). "Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface". Eur. J. Cell Biol. 56 (1): 58–67. PMID 1724753.CS1 maint: Multiple names: authors list (link)
• Choi-Miura NH, Tobe T, Sumiya J; et al. (1996). "Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator". J. Biochem. 119 (6): 1157–65. PMID 8827452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sumiya J, Asakawa S, Tobe T; et al. (1998). "Isolation and characterization of the plasma hyaluronan-binding protein (PHBP) gene (HABP2)". J. Biochem. 122 (5): 983–90. PMID 9443814.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Choi-Miura NH, Yoda M, Saito K; et al. (2001). "Identification of the substrates for plasma hyaluronan binding protein". Biol. Pharm. Bull. 24 (2): 140–3. PMID 11217080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Choi-Miura NH, Takahashi K, Yoda M; et al. (2001). "Proteolytic activation and inactivation of the serine protease activity of plasma hyaluronan binding protein". Biol. Pharm. Bull. 24 (5): 448–52. PMID 11379758.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roemisch J, Feussner A, Nerlich C; et al. (2003). "The frequent Marburg I polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP)". Blood Coagul. Fibrinolysis. 13 (5): 433–41. PMID 12138371.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang KK, Liu N, Radulovich N; et al. (2002). "Novel candidate tumor marker genes for lung adenocarcinoma". Oncogene. 21 (49): 7598–604. doi:10.1038/sj.onc.1205953. PMID 12386823.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Etscheid M, Beer N, Fink E; et al. (2003). "The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin". Biol. Chem. 383 (10): 1633–43. PMID 12452440.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Willeit J, Kiechl S, Weimer T; et al. (2003). "Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis". Circulation. 107 (5): 667–70. PMID 12578864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anderson NL, Polanski M, Pieper R; et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoppe B, Tolou F, Radtke H; et al. (2005). "Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism". Blood. 105 (4): 1549–51. doi:10.1182/blood-2004-08-3328. PMID 15486068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ireland H, Miller GJ, Webb KE; et al. (2005). "The factor VII activating protease G511E (Marburg) variant and cardiovascular risk". Thromb. Haemost. 92 (5): 986–92. doi:10.1267/THRO04050986. PMID 15543324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakazawa F, Kannemeier C, Shibamiya A; et al. (2005). "Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP)". Biochem. J. 385 (Pt 3): 831–8. doi:10.1042/BJ20041021. PMID 15654766.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Minkelen R, de Visser MC, Vos HL; et al. (2005). "The Marburg I polymorphism of factor VII-activating protease is not associated with venous thrombosis". Blood. 105 (12): 4898, author reply 4899. doi:10.1182/blood-2005-02-0576. PMID 15933067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Etscheid M, Beer N, Dodt J (2006). "The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration". Cell. Signal. 17 (12): 1486–94. doi:10.1016/j.cellsig.2005.03.007. PMID 16153533.CS1 maint: Multiple names: authors list (link)