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G protein pathway suppressor 2
Identifiers
Symbols GPS2 ; AMF-1; MGC104294; MGC119287; MGC119288; MGC119289
External IDs Template:OMIM5 Template:MGI HomoloGene: 49599
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

G protein pathway suppressor 2, also known as GPS2, is a human gene.[1]

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: GPS2 G protein pathway suppressor 2".

Further reading

  • Spain BH, Bowdish KS, Pacal AR; et al. (1997). "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells". Mol. Cell. Biol. 16 (12): 6698–706. PMID 8943324.
  • Jin DY, Teramoto H, Giam CZ; et al. (1997). "A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha". J. Biol. Chem. 272 (41): 25816–23. PMID 9325311.
  • Peng YC, Breiding DE, Sverdrup F; et al. (2000). "AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins". J. Virol. 74 (13): 5872–9. PMID 10846067.
  • Degenhardt YY, Silverstein SJ (2001). "Gps2, a protein partner for human papillomavirus E6 proteins". J. Virol. 75 (1): 151–60. doi:10.1128/JVI.75.1.151-160.2001. PMID 11119584.
  • Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
  • Nagase T, Nakayama M, Nakajima D; et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. PMID 11347906.
  • Peng YC, Kuo F, Breiding DE; et al. (2001). "AMF1 (GPS2) modulates p53 transactivation". Mol. Cell. Biol. 21 (17): 5913–24. PMID 11486030.
  • Zhang J, Kalkum M, Chait BT, Roeder RG (2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell. 9 (3): 611–23. PMID 11931768.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Yoon HG, Chan DW, Huang ZQ; et al. (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMID 12628926.
  • Yoon HG, Chan DW, Reynolds AB; et al. (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell. 12 (3): 723–34. PMID 14527417.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Diederichs S, Bäumer N, Ji P; et al. (2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". J. Biol. Chem. 279 (32): 33727–41. doi:10.1074/jbc.M401708200. PMID 15159402.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Lee TH, Yi W, Griswold MD; et al. (2006). "Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment". DNA Repair (Amst.). 5 (1): 32–42. doi:10.1016/j.dnarep.2005.07.004. PMID 16122992.
  • Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
  • Sanyal S, Båvner A, Haroniti A; et al. (2007). "Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis". Proc. Natl. Acad. Sci. U.S.A. 104 (40): 15665–70. doi:10.1073/pnas.0706736104. PMID 17895379.

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