DLGAP1

Discs, large (Drosophila) homolog-associated protein 1
Identifiers
Symbols	DLGAP1 ; DAP-1; DAP-1-ALPHA; DAP-1-BETA; GKAP; MGC88156; SAPAP1; hGKAP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31258
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Discs, large (Drosophila) homolog-associated protein 1, also known as DLGAP1 is a human gene. This gene encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the SHANK and PSD-95 proteins fascilitating the assembly of the post synaptic density of neurons..

Further reading

• Kim E, Naisbitt S, Hsueh YP; et al. (1997). "GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules". J. Cell Biol. 136 (3): 669–78. PMID 9024696.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeuchi M, Hata Y, Hirao K; et al. (1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J. Biol. Chem. 272 (18): 11943–51. PMID 9115257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Naisbitt S, Kim E, Weinberg RJ; et al. (1997). "Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90". J. Neurosci. 17 (15): 5687–96. PMID 9221768.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Satoh K, Yanai H, Senda T; et al. (1997). "DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95". Genes Cells. 2 (6): 415–24. PMID 9286858.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirao K, Hata Y, Ide N; et al. (1998). "A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins". J. Biol. Chem. 273 (33): 21105–10. PMID 9694864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deguchi M, Hata Y, Takeuchi M; et al. (1998). "BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein". J. Biol. Chem. 273 (41): 26269–72. PMID 9756850.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawabe H, Hata Y, Takeuchi M; et al. (1999). "nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP)". J. Biol. Chem. 274 (43): 30914–8. PMID 10521485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boeckers TM, Winter C, Smalla KH; et al. (1999). "Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family". Biochem. Biophys. Res. Commun. 264 (1): 247–52. doi:10.1006/bbrc.1999.1489. PMID 10527873.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Naisbitt S, Valtschanoff J, Allison DW; et al. (2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. 20 (12): 4524–34. PMID 10844022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu H, Reissner C, Kuhlendahl S; et al. (2000). "Intramolecular interactions regulate SAP97 binding to GKAP". EMBO J. 19 (21): 5740–51. doi:10.1093/emboj/19.21.5740. PMID 11060025.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haraguchi K, Satoh K, Yanai H; et al. (2001). "The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase". Genes Cells. 5 (11): 905–911. PMID 11122378.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lo KW, Naisbitt S, Fan JS; et al. (2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". J. Biol. Chem. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Im YJ, Lee JH, Park SH; et al. (2004). "Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization". J. Biol. Chem. 278 (48): 48099–104. doi:10.1074/jbc.M306919200. PMID 12954649.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki T, Li W, Zhang JP; et al. (2005). "A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins". Eur. J. Neurosci. 21 (2): 339–50. doi:10.1111/j.1460-9568.2005.03856.x. PMID 15673434.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sabio G, Arthur JS, Kuma Y; et al. (2005). "p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP". EMBO J. 24 (6): 1134–45. doi:10.1038/sj.emboj.7600578. PMID 15729360.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)