ARFGEF1

ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Identifiers
Symbols	ARFGEF1 ; P200; ARFGEP1; BIG1; D730028O18Rik; DKFZP434L057
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4687
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited), also known as ARFGEF1, is a human gene.

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Morinaga N, Tsai SC, Moss J, Vaughan M (1996). "Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12856–60. PMID 8917509.CS1 maint: Multiple names: authors list (link)
• Togawa A, Morinaga N, Ogasawara M; et al. (1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". J. Biol. Chem. 274 (18): 12308–15. PMID 10212200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mansour SJ, Skaug J, Zhao XH; et al. (1999). "p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A.". Proc. Natl. Acad. Sci. U.S.A. 96 (14): 7968–73. PMID 10393931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamaji R, Adamik R, Takeda K; et al. (2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2567–72. PMID 10716990.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamei Y, Takeda Y, Teramoto K; et al. (2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics. 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Padilla PI, Chang MJ, Pacheco-Rodriguez G; et al. (2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2322–7. doi:10.1073/pnas.2628047100. PMID 12606707.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M (2004). "Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2752–7. doi:10.1073/pnas.0307345101. PMID 14973189.CS1 maint: Multiple names: authors list (link)
• Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity". J. Biol. Chem. 280 (11): 10128–34. doi:10.1074/jbc.M413415200. PMID 15644318.CS1 maint: Multiple names: authors list (link)
• Citterio C, Jones HD, Pacheco-Rodriguez G; et al. (2006). "Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei". Proc. Natl. Acad. Sci. U.S.A. 103 (8): 2683–8. doi:10.1073/pnas.0510571103. PMID 16467138.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Belov GA, Altan-Bonnet N, Kovtunovych G; et al. (2007). "Hijacking components of the cellular secretory pathway for replication of poliovirus RNA". J. Virol. 81 (2): 558–67. doi:10.1128/JVI.01820-06. PMID 17079330.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shen X, Hong MS, Moss J, Vaughan M (2007). "BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1230–5. doi:10.1073/pnas.0610535104. PMID 17227842.CS1 maint: Multiple names: authors list (link)
• Kuroda F, Moss J, Vaughan M (2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3201–6. doi:10.1073/pnas.0611696104. PMID 17360629.CS1 maint: Multiple names: authors list (link)