Primary ciliary dyskinesia differential diagnosis: Difference between revisions

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{{Primary ciliary dyskinesia}}
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==Overview==
[[Primary ciliary dyskinesia]] must be differentiated from other conditions that cause [[infertility]], [[sinusitis]], [[otitis media]], and [[rhinitis]].
 
==Differentiating Primary ciliary dyskinesia from other Diseases==
primary ciliary dyskinesia should be differentiated from other diseases that cause [[rhinosinusitis]], [[otitis media]], and [[infertility]].
 
*[[Cystic fibrosis]]
*[[Alpha1 antitrypsin deficiency]]
*[[Allergic bronchopulmonary aspergillosis]].
*[[Foreign body aspiration]]
*[[Immunosuppression]].<ref>{{cite web |url=https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=244 |title=Orphanet: Primary ciliary dyskinesia |format= |work= |accessdate=}}</ref><ref>{{cite web |url=https://medlineplus.gov/lab-tests/alpha-1-antitrypsin-test/ |title=Alpha-1 Antitrypsin Test: MedlinePlus Medical Test |format= |work= |accessdate=}}</ref><ref>{{cite web |url=https://emedicine.medscape.com/article/1001602-overview |title=Cystic Fibrosis: Practice Essentials, Background, Pathophysiology |format= |work= |accessdate=}}</ref><ref>{{cite web |url=https://www.mayoclinic.org/diseases-conditions/aspergillosis/diagnosis-treatment/drc-20369623 |title=Aspergillosis - Diagnosis and treatment - Mayo Clinic |format= |work= |accessdate=}}</ref>
 
On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].
{|
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
|
| colspan="4" |'''Clinical manifestations'''
! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
| colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Gold standard'''
|-
|
| colspan="2" rowspan="2" |'''Symptoms'''
! colspan="2" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical examination
|-
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Age Of Onset
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |nasal discharge
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |cough
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |wheeze
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |jaundice
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Blood levels
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Xray chest
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |CT scan
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Cystic fibrosis.
| style="background: #F5F5F5; padding: 5px;" |Infancy
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |Hyperinflation,
Peri bronchial thickening
| style="background: #F5F5F5; padding: 5px;" |Not indicated.
| style="background: #F5F5F5; padding: 5px;" |Genotyping
CFTR gene mutation.
 
Sweat chloride test.
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |
*Alpha1-Antitrypsin (AAT) Deficiency
| style="background: #F5F5F5; padding: 5px;" |
 
 
 
40-50
| style="background: #F5F5F5; padding: 5px;" |
 
 
_
| style="background: #F5F5F5; padding: 5px;" |
 
 
+
| style="background: #F5F5F5; padding: 5px;" |
 
 
+
| style="background: #F5F5F5; padding: 5px;" |
 
 
+
| style="background: #F5F5F5; padding: 5px;" |
 
 
decreased AAT levels
| style="background: #F5F5F5; padding: 5px;" |Hyper lucency in lungs.
| style="background: #F5F5F5; padding: 5px;" |
 
 
-
| style="background: #F5F5F5; padding: 5px;" |Blood test.
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Allergic Broncho pulmonary aspergillosis.
| style="background: #F5F5F5; padding: 5px;" |40-50
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |Eosinophilia.
| style="background: #F5F5F5; padding: 5px;" |Round mass with air-crescent sign.
| style="background: #F5F5F5; padding: 5px;" |Aspergilloma on CT chest.
| style="background: #F5F5F5; padding: 5px;" |Sputum analysis.
Lung biopsy for fungal culture
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
!Diseases
!cough
! colspan="1" rowspan="1" |nasal discharge
!
!wheeze
! colspan="1" rowspan="1" |
!Lab 1
!X-ray
!CT scan
|'''Gold standard'''
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Immunodeficiency.
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|}


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Genetic disorders]]
[[Category:Genetic disorders]]
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[[Category:Cardiology]]
[[Category:Cardiology]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Needs content]]
 


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Latest revision as of 12:42, 23 September 2021

link=https://www.wikidoc.org/index.php/Primary ciliary dyskinesia
link=https://www.wikidoc.org/index.php/Primary ciliary dyskinesia

Template:Atherosclerosis Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Hafsa Ghaffar, M.B.B.S[2]

Overview

Primary ciliary dyskinesia must be differentiated from other conditions that cause infertility, sinusitis, otitis media, and rhinitis.

Differentiating Primary ciliary dyskinesia from other Diseases

primary ciliary dyskinesia should be differentiated from other diseases that cause rhinosinusitis, otitis media, and infertility.

On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

Diseases Clinical manifestations Para-clinical findings Gold standard
Symptoms Physical examination
Lab Findings Imaging
Age Of Onset nasal discharge cough wheeze jaundice Blood levels Xray chest CT scan
Cystic fibrosis. Infancy + + + - - Hyperinflation,

Peri bronchial thickening

Not indicated. Genotyping

CFTR gene mutation.

Sweat chloride test.

  • Alpha1-Antitrypsin (AAT) Deficiency


40-50


_


+


+


+


decreased AAT levels

Hyper lucency in lungs.


-

Blood test.
Allergic Broncho pulmonary aspergillosis. 40-50 - + + - Eosinophilia. Round mass with air-crescent sign. Aspergilloma on CT chest. Sputum analysis.

Lung biopsy for fungal culture

Diseases cough nasal discharge wheeze Lab 1 X-ray CT scan Gold standard
Immunodeficiency.

References

  1. ↑ "Orphanet: Primary ciliary dyskinesia".
  2. ↑ "Alpha-1 Antitrypsin Test: MedlinePlus Medical Test".
  3. ↑ "Cystic Fibrosis: Practice Essentials, Background, Pathophysiology".
  4. ↑ "Aspergillosis - Diagnosis and treatment - Mayo Clinic".


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