Dementia other diagnostic studies: Difference between revisions
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{{Template:Dementia}} | {{Template:Dementia}} | ||
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== Overview == | |||
Most patients do not require a full neuropsychological examination as part of an evaluation for dementia; however, testing is useful when bedside cognitive testing is equivocal. Follow-up testing or just serial observations generally provide more helpful information than a single study, particularly when results are equivocal.<ref name="pmid18714062">{{cite journal |vauthors=Holtzer R, Verghese J, Wang C, Hall CB, Lipton RB |title=Within-person across-neuropsychological test variability and incident dementia |journal=JAMA |volume=300 |issue=7 |pages=823–30 |date=August 2008 |pmid=18714062 |pmc=2736784 |doi=10.1001/jama.300.7.823 |url=}}</ref> | |||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
Different diagnostic modalities used to make in diagnosis of dementias include: | |||
*Genetic testing | *Genetic testing | ||
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*Lumber puncture | *Lumber puncture | ||
*[[Brain biopsy]] | *[[Brain biopsy]] | ||
*Positron emission tomography (PET)<ref name="pmid12940841">{{cite journal |vauthors=Mirzaei S, Rodrigues M, Koehn H, Knoll P, Bruecke T |title=Metabolic impairment of brain metabolism in patients with Lewy body dementia |journal=Eur. J. Neurol. |volume=10 |issue=5 |pages=573–5 |date=September 2003 |pmid=12940841 |doi=10.1046/j.1468-1331.2003.00650.x |url=}}</ref> | *Positron emission tomography (PET)<ref name="pmid12940841">{{cite journal |vauthors=Mirzaei S, Rodrigues M, Koehn H, Knoll P, Bruecke T |title=Metabolic impairment of brain metabolism in patients with Lewy body dementia |journal=Eur. J. Neurol. |volume=10 |issue=5 |pages=573–5 |date=September 2003 |pmid=12940841 |doi=10.1046/j.1468-1331.2003.00650.x |url=}}</ref> <ref name="pmid11245717">{{cite journal |vauthors=Lobotesis K, Fenwick JD, Phipps A, Ryman A, Swann A, Ballard C, McKeith IG, O'Brien JT |title=Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD |journal=Neurology |volume=56 |issue=5 |pages=643–9 |date=March 2001 |pmid=11245717 |doi=10.1212/wnl.56.5.643 |url=}}</ref> | ||
*Single-photon emission computed tomography ([[SPECT]]) | *Single-photon emission computed tomography ([[SPECT]])<ref name="pmid11976799">{{cite journal |vauthors=Colloby SJ, Fenwick JD, Williams ED, Paling SM, Lobotesis K, Ballard C, McKeith I, O'Brien JT |title=A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping |journal=Eur. J. Nucl. Med. Mol. Imaging |volume=29 |issue=5 |pages=615–22 |date=May 2002 |pmid=11976799 |doi=10.1007/s00259-002-0778-5 |url=}}</ref> | ||
*[[Venereal disease research laboratory (VDRL) test|VDRL]] | *[[Venereal disease research laboratory (VDRL) test|VDRL]] | ||
*HIV testing | *HIV testing | ||
Latest revision as of 15:50, 9 October 2020
|
Dementia Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Most patients do not require a full neuropsychological examination as part of an evaluation for dementia; however, testing is useful when bedside cognitive testing is equivocal. Follow-up testing or just serial observations generally provide more helpful information than a single study, particularly when results are equivocal.[1]
Other Diagnostic Studies
Different diagnostic modalities used to make in diagnosis of dementias include:
- Genetic testing
- Cerebrospinal fluid (CSF) analysis is suggested in some cases
- Electroencephalogram (EEG) may be used to diagnose Creutzfeldt-Jakob disease or underlying metabolic/toxic disorders
- Lumber puncture
- Brain biopsy
- Positron emission tomography (PET)[2] [3]
- Single-photon emission computed tomography (SPECT)[4]
- VDRL
- HIV testing
References
- ↑ Holtzer R, Verghese J, Wang C, Hall CB, Lipton RB (August 2008). "Within-person across-neuropsychological test variability and incident dementia". JAMA. 300 (7): 823–30. doi:10.1001/jama.300.7.823. PMC 2736784. PMID 18714062.
- ↑ Mirzaei S, Rodrigues M, Koehn H, Knoll P, Bruecke T (September 2003). "Metabolic impairment of brain metabolism in patients with Lewy body dementia". Eur. J. Neurol. 10 (5): 573–5. doi:10.1046/j.1468-1331.2003.00650.x. PMID 12940841.
- ↑ Lobotesis K, Fenwick JD, Phipps A, Ryman A, Swann A, Ballard C, McKeith IG, O'Brien JT (March 2001). "Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD". Neurology. 56 (5): 643–9. doi:10.1212/wnl.56.5.643. PMID 11245717.
- ↑ Colloby SJ, Fenwick JD, Williams ED, Paling SM, Lobotesis K, Ballard C, McKeith I, O'Brien JT (May 2002). "A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping". Eur. J. Nucl. Med. Mol. Imaging. 29 (5): 615–22. doi:10.1007/s00259-002-0778-5. PMID 11976799.