Aortic stenosis causes: Difference between revisions
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{{Aortic stenosis}} | {{Aortic stenosis}} | ||
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[User:Mohammed Sbeih|Mohammed A. Sbeih, M.D.]] [mailto:msbeih@wikidoc.org]; {{LG}}; {{VR}}; {{USAMA}} '''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu] | {{CMG}}; '''Associate Editor(s)-In-Chief:''' [[User:Mohammed Sbeih|Mohammed A. Sbeih, M.D.]] [mailto:msbeih@wikidoc.org]; {{LG}}; {{VR}}; {{USAMA}} {{MC}} '''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu] | ||
==Overview== | ==Overview== | ||
Aortic stenosis can be either congenital or acquired, and its common causes vary between different age groups and between different populations. [[Rheumatic heart disease]] remains the most common cause of aortic stenosis worldwide. Calcification of the [[aortic valve]] is the most common cause of aortic stenosis in North America and Europe | Aortic stenosis can be either congenital or acquired, and its common causes vary between different age groups and between different populations. [[Rheumatic heart disease]] remains the most common cause of aortic stenosis worldwide. Calcification of the [[aortic valve]] is the most common cause of aortic stenosis in North America and Europe. While calcification of [[Bicuspid aortic stenosis|congenital bicuspid aortic valve]] is the most common cause of aortic stenosis in people less than 70 years of age, acquired degenerative calcific aortic stenosis is the most common cause in older patients above the age of 70 years. | ||
==Causes== | ==Causes== | ||
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===Common Causes=== | ===Common Causes=== | ||
Common causes of aortic stenosis may include:<ref name="pmid16709942">{{cite journal |author=O'Brien KD |title=Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more) |journal=[[Arteriosclerosis, Thrombosis, and Vascular Biology]] |volume=26 |issue=8 |pages=1721–8 |year=2006 |month=August |pmid=16709942 |doi=10.1161/01.ATV.0000227513.13697.ac |url=http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=16709942 |accessdate=2012-04-11}}</ref><ref name="pmid22685681">{{cite journal| author=Mordi I, Tzemos N| title=Bicuspid aortic valve disease: a comprehensive review. | journal=Cardiol Res Pract | year= 2012 | volume= 2012 | issue= | pages= 196037 | pmid=22685681 | doi=10.1155/2012/196037 | pmc=3368178 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22685681 }} </ref><ref name="Lugiano-2013">{{Cite journal | last1 = Lugiano | first1 = CA. | title = Aortic stenosis. | journal = JAAPA | volume = 26 | issue = 11 | pages = 46-7 | month = Nov | year = 2013 | doi = 10.1097/01.JAA.0000436518.69169.8e | PMID = 24153092 }}</ref><ref name="uas">VOC=VITIUM ORGANICUM CORDIS, a compendium of the Department of Cardiology at Uppsala Academic Hospital. By Per Kvidal September 1999, with revision by Erik Björklund May 2008</ref> | |||
*[[Calcific aortic valve disease]] | |||
*A congenitally abnormal aortic valve with superimposed calcification (unicuspid or [[Bicuspid Aortic Valve|bicuspid]]). | |||
*[[Rheumatic fever|Rheumatic heart disease]] | |||
===Causes by Location of Stenosis=== | ===Causes by Location of Stenosis=== | ||
====Valvular Aortic Stenosis==== | ====Valvular Aortic Stenosis==== | ||
*Acquired | *Acquired | ||
**[[Alkaptonuria]]<ref name="pmid22100375">{{cite journal| author=Hannoush H, Introne WJ, Chen MY, Lee SJ, O'Brien K, Suwannarat P et al.| title=Aortic stenosis and vascular calcifications in alkaptonuria. | journal=Mol Genet Metab | year= 2012 | volume= 105 | issue= 2 | pages= 198-202 | pmid=22100375 | doi=10.1016/j.ymgme.2011.10.017 | pmc=PMC3276068 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22100375 }} </ref> | **[[Alkaptonuria]]<ref name="pmid22100375">{{cite journal| author=Hannoush H, Introne WJ, Chen MY, Lee SJ, O'Brien K, Suwannarat P et al.| title=Aortic stenosis and vascular calcifications in alkaptonuria. | journal=Mol Genet Metab | year= 2012 | volume= 105 | issue= 2 | pages= 198-202 | pmid=22100375 | doi=10.1016/j.ymgme.2011.10.017 | pmc=PMC3276068 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22100375 }} </ref> | ||
**[[Aortic sclerosis]]<ref name="Aronow-2013">{{Cite journal | last1 = Aronow | first1 = WS. | title = A review of the pathophysiology, diagnosis, and treatment of aortic valve stenosis in elderly patients. | journal = Hosp Pract (1995) | volume = 41 | issue = 4 | pages = 66-77 | month = Oct | year = 2013 | doi = 10.3810/hp.2013.10.1082 | PMID = 24145591 }}</ref> | **[[Aortic sclerosis]]<ref name="Aronow-2013">{{Cite journal | last1 = Aronow | first1 = WS. | title = A review of the pathophysiology, diagnosis, and treatment of aortic valve stenosis in elderly patients. | journal = Hosp Pract (1995) | volume = 41 | issue = 4 | pages = 66-77 | month = Oct | year = 2013 | doi = 10.3810/hp.2013.10.1082 | PMID = 24145591 }}</ref> | ||
**[[Hyperuricemia]]<ref name="pmid17921746">{{cite journal| author=Moura LM, Maganti K, Puthumana JJ, Rocha-Gonçalves F, Rajamannan NM| title=New understanding about calcific aortic stenosis and opportunities for pharmacologic intervention. | journal=Curr Opin Cardiol | year= 2007 | volume= 22 | issue= 6 | pages= 572-7 | pmid=17921746 | doi=10.1097/HCO.0b013e3282f0dae6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17921746 }} </ref> | **[[Hyperuricemia]]<ref name="pmid17921746">{{cite journal| author=Moura LM, Maganti K, Puthumana JJ, Rocha-Gonçalves F, Rajamannan NM| title=New understanding about calcific aortic stenosis and opportunities for pharmacologic intervention. | journal=Curr Opin Cardiol | year= 2007 | volume= 22 | issue= 6 | pages= 572-7 | pmid=17921746 | doi=10.1097/HCO.0b013e3282f0dae6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17921746 }} </ref> | ||
**[[Paget's disease]]<ref>Strickberger SA, Schulman SP, Hutchins GM. Association of Paget’s disease of bone with calcific aortic valve disease. Am J Med 1987;82:953-6.</ref> | **[[Paget's disease]]<ref>Strickberger SA, Schulman SP, Hutchins GM. Association of Paget’s disease of bone with calcific aortic valve disease. Am J Med 1987;82:953-6.</ref> | ||
**[[Radiation]] <ref name="pmid24597417">{{cite journal| author=Ong DS, Aertker RA, Clark AN, Kiefer T, Hughes GC, Harrison JK et al.| title=Radiation-associated valvular heart disease. | journal=J Heart Valve Dis | year= 2013 | volume= 22 | issue= 6 | pages= 883-92 | pmid=24597417 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24597417 }} </ref> | **[[Radiation]] <ref name="pmid24597417">{{cite journal| author=Ong DS, Aertker RA, Clark AN, Kiefer T, Hughes GC, Harrison JK et al.| title=Radiation-associated valvular heart disease. | journal=J Heart Valve Dis | year= 2013 | volume= 22 | issue= 6 | pages= 883-92 | pmid=24597417 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24597417 }} </ref> | ||
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**[[Systemic lupus erythematosus]]<ref name="pmid23884983">{{cite journal| author=Bert JS, Abdullah M, Dahle TG, Gertner E| title=Transcatheter aortic valve replacement for advanced valvular disease in active SLE and APS. | journal=Lupus | year= 2013 | volume= 22 | issue= 10 | pages= 1046-9 | pmid=23884983 | doi=10.1177/0961203313498797 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23884983 }} </ref> | **[[Systemic lupus erythematosus]]<ref name="pmid23884983">{{cite journal| author=Bert JS, Abdullah M, Dahle TG, Gertner E| title=Transcatheter aortic valve replacement for advanced valvular disease in active SLE and APS. | journal=Lupus | year= 2013 | volume= 22 | issue= 10 | pages= 1046-9 | pmid=23884983 | doi=10.1177/0961203313498797 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23884983 }} </ref> | ||
*Congenital | *Congenital | ||
**[[Bardet-Biedl syndrome]]<ref name="pmid10874630">{{cite journal| author=Beales PL, Elcioglu N, Woolf AS, Parker D, Flinter FA| title=New criteria for improved diagnosis of Bardet-Biedl syndrome: results of a population survey. | journal=J Med Genet | year= 1999 | volume= 36 | issue= 6 | pages= 437-46 | pmid=10874630 | doi= | pmc=1734378 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10874630 }} </ref> | **[[Bardet-Biedl syndrome]]<ref name="pmid10874630">{{cite journal| author=Beales PL, Elcioglu N, Woolf AS, Parker D, Flinter FA| title=New criteria for improved diagnosis of Bardet-Biedl syndrome: results of a population survey. | journal=J Med Genet | year= 1999 | volume= 36 | issue= 6 | pages= 437-46 | pmid=10874630 | doi= | pmc=1734378 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10874630 }} </ref> | ||
**[[Bicuspid aortic valve]]<ref name="pmid22685681">{{cite journal| author=Mordi I, Tzemos N| title=Bicuspid aortic valve disease: a comprehensive review. | journal=Cardiol Res Pract | year= 2012 | volume= 2012 | issue= | pages= 196037 | pmid=22685681 | doi=10.1155/2012/196037 | pmc=3368178 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22685681 }} </ref> | **[[Bicuspid aortic valve]]<ref name="pmid22685681">{{cite journal| author=Mordi I, Tzemos N| title=Bicuspid aortic valve disease: a comprehensive review. | journal=Cardiol Res Pract | year= 2012 | volume= 2012 | issue= | pages= 196037 | pmid=22685681 | doi=10.1155/2012/196037 | pmc=3368178 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22685681 }} </ref> | ||
**[[Fabry's disease]]<ref name="pmid7596372">{{cite journal| author=Nakao S, Takenaka T, Maeda M, Kodama C, Tanaka A, Tahara M et al.| title=An atypical variant of Fabry's disease in men with left ventricular hypertrophy. | journal=N Engl J Med | year= 1995 | volume= 333 | issue= 5 | pages= 288-93 | pmid=7596372 | doi=10.1056/NEJM199508033330504 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7596372 }} </ref> | **[[Fabry's disease]]<ref name="pmid7596372">{{cite journal| author=Nakao S, Takenaka T, Maeda M, Kodama C, Tanaka A, Tahara M et al.| title=An atypical variant of Fabry's disease in men with left ventricular hypertrophy. | journal=N Engl J Med | year= 1995 | volume= 333 | issue= 5 | pages= 288-93 | pmid=7596372 | doi=10.1056/NEJM199508033330504 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7596372 }} </ref> | ||
**[[Familial hypercholesterolemia]]<ref name="pmid6331147">{{cite journal| author=Sprecher DL, Schaefer EJ, Kent KM, Gregg RE, Zech LA, Hoeg JM et al.| title=Cardiovascular features of homozygous familial hypercholesterolemia: analysis of 16 patients. | journal=Am J Cardiol | year= 1984 | volume= 54 | issue= 1 | pages= 20-30 | pmid=6331147 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6331147 }} </ref> | **[[Familial hypercholesterolemia]]<ref name="pmid6331147">{{cite journal| author=Sprecher DL, Schaefer EJ, Kent KM, Gregg RE, Zech LA, Hoeg JM et al.| title=Cardiovascular features of homozygous familial hypercholesterolemia: analysis of 16 patients. | journal=Am J Cardiol | year= 1984 | volume= 54 | issue= 1 | pages= 20-30 | pmid=6331147 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6331147 }} </ref> | ||
**[[Familial thoracic aortic aneurysm|Familial thoracic aortic aneurysm syndrome]]<ref name="pmid17676603">{{cite journal| author=Loscalzo ML, Goh DL, Loeys B, Kent KC, Spevak PJ, Dietz HC| title=Familial thoracic aortic dilation and bicommissural aortic valve: a prospective analysis of natural history and inheritance. | journal=Am J Med Genet A | year= 2007 | volume= 143A | issue= 17 | pages= 1960-7 | pmid=17676603 | doi=10.1002/ajmg.a.31872 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17676603 }} </ref> | **[[Familial thoracic aortic aneurysm|Familial thoracic aortic aneurysm syndrome]]<ref name="pmid17676603">{{cite journal| author=Loscalzo ML, Goh DL, Loeys B, Kent KC, Spevak PJ, Dietz HC| title=Familial thoracic aortic dilation and bicommissural aortic valve: a prospective analysis of natural history and inheritance. | journal=Am J Med Genet A | year= 2007 | volume= 143A | issue= 17 | pages= 1960-7 | pmid=17676603 | doi=10.1002/ajmg.a.31872 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17676603 }} </ref> | ||
**[[Aortic valve#Disease of the aortic valve|Hypoplastic aortic annulus]]<ref name="REEVE-1964">{{Cite journal | last1 = REEVE | first1 = R. | last2 = ROBINSON | first2 = SJ. | title = HYPOPLASTIC ANNULUS--AN UNUSUAL TYPE OF AORTIC STENOSIS: A REPORT OF THREE CASES IN CHILDREN. | journal = Dis Chest | volume = 45 | issue = | pages = 99-102 | month = Jan | year = 1964 | doi = | PMID = 14114644 }}</ref> | **[[Aortic valve#Disease of the aortic valve|Hypoplastic aortic annulus]]<ref name="REEVE-1964">{{Cite journal | last1 = REEVE | first1 = R. | last2 = ROBINSON | first2 = SJ. | title = HYPOPLASTIC ANNULUS--AN UNUSUAL TYPE OF AORTIC STENOSIS: A REPORT OF THREE CASES IN CHILDREN. | journal = Dis Chest | volume = 45 | issue = | pages = 99-102 | month = Jan | year = 1964 | doi = | PMID = 14114644 }}</ref> | ||
** | **Subaortic stenosis short stature syndrome (Onat syndrome) <ref name="urlSubaortic stenosis short stature syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program">{{cite web |url=https://rarediseases.info.nih.gov/diseases/405/subaortic-stenosis-short-stature-syndrome |title=Subaortic stenosis short stature syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program |format= |work= |accessdate=}}</ref> | ||
**[[Quadricuspid aortic valve]]<ref name="pmid27278482">{{cite journal| author=Yamagishi Y, Yuda S, Tsuchihashi K, Saitoh S, Miura T, Ura N et al.| title=Quadricuspid aortic valve associated with aortic stenosis and regurgitation: report of a case and a review of the literature. | journal=J Med Ultrason (2001) | year= 2007 | volume= 34 | issue= 4 | pages= 197-200 | pmid=27278482 | doi=10.1007/s10396-007-0148-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27278482 }} </ref> | **[[Quadricuspid aortic valve]]<ref name="pmid27278482">{{cite journal| author=Yamagishi Y, Yuda S, Tsuchihashi K, Saitoh S, Miura T, Ura N et al.| title=Quadricuspid aortic valve associated with aortic stenosis and regurgitation: report of a case and a review of the literature. | journal=J Med Ultrason (2001) | year= 2007 | volume= 34 | issue= 4 | pages= 197-200 | pmid=27278482 | doi=10.1007/s10396-007-0148-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27278482 }} </ref> | ||
**[[Singleton-Merten syndrome]]<ref name="pmid23322711">{{cite journal| author=Feigenbaum A, Müller C, Yale C, Kleinheinz J, Jezewski P, Kehl HG et al.| title=Singleton-Merten syndrome: an autosomal dominant disorder with variable expression. | journal=Am J Med Genet A | year= 2013 | volume= 161A | issue= 2 | pages= 360-70 | pmid=23322711 | doi=10.1002/ajmg.a.35732 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23322711 }} </ref> | **[[Singleton-Merten syndrome]]<ref name="pmid23322711">{{cite journal| author=Feigenbaum A, Müller C, Yale C, Kleinheinz J, Jezewski P, Kehl HG et al.| title=Singleton-Merten syndrome: an autosomal dominant disorder with variable expression. | journal=Am J Med Genet A | year= 2013 | volume= 161A | issue= 2 | pages= 360-70 | pmid=23322711 | doi=10.1002/ajmg.a.35732 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23322711 }} </ref> | ||
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{|style="width:80%; height:100px" border="1" | {|style="width:80%; height:100px" border="1" | ||
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular''' | |style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular''' | ||
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | Age-induced calcification, [[aortic sclerosis]], [[aortitis]], [[bicuspid aortic valve]] or [[Bicuspid aortic stenosis|bicommissural aortic valve]], prosthetic aortic valve, [[hypertrophic cardiomyopathy]], [[Aortic valve#Disease of the aortic valve|hypoplastic aortic annulus]], [[hypoplastic left heart syndrome]], [[idiopathic hypertrophic subaortic stenosis | |style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | Age-induced calcification, [[aortic sclerosis]], [[aortitis]], [[bicuspid aortic valve]] or [[Bicuspid aortic stenosis|bicommissural aortic valve]], prosthetic aortic valve, [[hypertrophic cardiomyopathy]], [[Aortic valve#Disease of the aortic valve|hypoplastic aortic annulus]], [[hypoplastic left heart syndrome]], [[idiopathic hypertrophic subaortic stenosis]], [[quadricuspid aortic valve]], [[rheumatic fever]], [[Aortic valve#Disease of the aortic valve|tricuspid aortic valve with commissural fushion]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Infectious Disease''' | | '''Infectious Disease''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[rheumatic fever]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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{{col-begin|width=80%}} | {{col-begin|width=80%}} | ||
{{col-break|width=33%}} | {{col-break|width=33%}} | ||
*[[Alkaptonuria]] | *[[Alkaptonuria]] | ||
*[[Aortic sclerosis]] | *[[Aortic sclerosis]] | ||
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*[[Bicuspid aortic stenosis|Bicommissural aortic valve]] | *[[Bicuspid aortic stenosis|Bicommissural aortic valve]] | ||
*[[Bicuspid aortic valve]] | *[[Bicuspid aortic valve]] | ||
*[[Fabry's disease]] | *[[Fabry's disease]] | ||
*[[Subvalvular aortic stenosis|Familial subvalvular aortic stenosis]] | *[[Subvalvular aortic stenosis|Familial subvalvular aortic stenosis]] | ||
Line 214: | Line 206: | ||
*[[Hypoplastic left heart syndrome]] | *[[Hypoplastic left heart syndrome]] | ||
*[[Idiopathic hypertrophic subaortic stenosis]] | *[[Idiopathic hypertrophic subaortic stenosis]] | ||
*[[Loeys-Dietz syndrome]] | *[[Loeys-Dietz syndrome]] | ||
*[[Pseudo-Hurler polydystrophy|Mucolipidosis III gamma]] | *[[Pseudo-Hurler polydystrophy|Mucolipidosis III gamma]] |
Latest revision as of 17:08, 3 March 2020
Resident Survival Guide |
Aortic Stenosis Microchapters |
Diagnosis |
---|
Treatment |
Percutaneous Aortic Balloon Valvotomy (PABV) or Aortic Valvuloplasty |
Transcatheter Aortic Valve Replacement (TAVR) |
Case Studies |
Aortic stenosis causes On the Web |
American Roentgen Ray Society Images of Aortic stenosis causes |
Risk calculators and risk factors for Aortic stenosis causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Mohammed A. Sbeih, M.D. [2]; Lakshmi Gopalakrishnan, M.B.B.S. [3]; Vendhan Ramanujam M.B.B.S [4]; Usama Talib, BSc, MD [5] Mandana Chitsazan, M.D. [6] Assistant Editor-In-Chief: Kristin Feeney, B.S. [7]
Overview
Aortic stenosis can be either congenital or acquired, and its common causes vary between different age groups and between different populations. Rheumatic heart disease remains the most common cause of aortic stenosis worldwide. Calcification of the aortic valve is the most common cause of aortic stenosis in North America and Europe. While calcification of congenital bicuspid aortic valve is the most common cause of aortic stenosis in people less than 70 years of age, acquired degenerative calcific aortic stenosis is the most common cause in older patients above the age of 70 years.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. Aortic stenosis is a progressive disease and does not have a life threatening cause. However, complications resulting from untreated disease name is common.
Common Causes
Common causes of aortic stenosis may include:[1][2][3][4]
- Calcific aortic valve disease
- A congenitally abnormal aortic valve with superimposed calcification (unicuspid or bicuspid).
- Rheumatic heart disease
Causes by Location of Stenosis
Valvular Aortic Stenosis
- Acquired
- Congenital
- Bardet-Biedl syndrome[11]
- Bicuspid aortic valve[2]
- Fabry's disease[12]
- Familial hypercholesterolemia[13]
- Familial thoracic aortic aneurysm syndrome[14]
- Hypoplastic aortic annulus[15]
- Subaortic stenosis short stature syndrome (Onat syndrome) [16]
- Quadricuspid aortic valve[17]
- Singleton-Merten syndrome[18]
- Sweet syndrome[19]
- Tricuspid aortic valve with commissural fushion[20]
- Turner syndrome[21]
- Unicuspid aortic valve[22]
Subvalvular Aortic Stenosis
- Familial subvalvular aortic stenosis[23]
- Hypertrophic cardiomyopathy[24]
- Idiopathic hypertrophic subaortic stenosis[25]
Supravalvular Aortic Stenosis
- Aortitis[26]
- Familial supravalvular aortic stenosis[27]
- Homozygous familial hypercholesterolemia[28]
- Hypoplastic left heart syndrome[29]
- Williams syndrome[30][31]
Causes by Age Groups
Under Age 70
- Bicuspid aortic valve[32]
- Rheumatic heart disease[33]
- Degenerative calcification[34]
- Uni-commissural aortic valve[22]
- Hypoplasia of the annulus[35]
Over Age 70
- Degenerative calcification[34]
- Bicuspid aortic valve[2]
- Rheumatic heart disease[36]
- Hypoplasia of the annulus[35]
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ O'Brien KD (2006). "Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more)". Arteriosclerosis, Thrombosis, and Vascular Biology. 26 (8): 1721–8. doi:10.1161/01.ATV.0000227513.13697.ac. PMID 16709942. Retrieved 2012-04-11. Unknown parameter
|month=
ignored (help) - ↑ 2.0 2.1 2.2 Mordi I, Tzemos N (2012). "Bicuspid aortic valve disease: a comprehensive review". Cardiol Res Pract. 2012: 196037. doi:10.1155/2012/196037. PMC 3368178. PMID 22685681.
- ↑ Lugiano, CA. (2013). "Aortic stenosis". JAAPA. 26 (11): 46–7. doi:10.1097/01.JAA.0000436518.69169.8e. PMID 24153092. Unknown parameter
|month=
ignored (help) - ↑ 4.0 4.1 VOC=VITIUM ORGANICUM CORDIS, a compendium of the Department of Cardiology at Uppsala Academic Hospital. By Per Kvidal September 1999, with revision by Erik Björklund May 2008
- ↑ Hannoush H, Introne WJ, Chen MY, Lee SJ, O'Brien K, Suwannarat P; et al. (2012). "Aortic stenosis and vascular calcifications in alkaptonuria". Mol Genet Metab. 105 (2): 198–202. doi:10.1016/j.ymgme.2011.10.017. PMC 3276068. PMID 22100375.
- ↑ Aronow, WS. (2013). "A review of the pathophysiology, diagnosis, and treatment of aortic valve stenosis in elderly patients". Hosp Pract (1995). 41 (4): 66–77. doi:10.3810/hp.2013.10.1082. PMID 24145591. Unknown parameter
|month=
ignored (help) - ↑ Moura LM, Maganti K, Puthumana JJ, Rocha-Gonçalves F, Rajamannan NM (2007). "New understanding about calcific aortic stenosis and opportunities for pharmacologic intervention". Curr Opin Cardiol. 22 (6): 572–7. doi:10.1097/HCO.0b013e3282f0dae6. PMID 17921746.
- ↑ Strickberger SA, Schulman SP, Hutchins GM. Association of Paget’s disease of bone with calcific aortic valve disease. Am J Med 1987;82:953-6.
- ↑ Ong DS, Aertker RA, Clark AN, Kiefer T, Hughes GC, Harrison JK; et al. (2013). "Radiation-associated valvular heart disease". J Heart Valve Dis. 22 (6): 883–92. PMID 24597417.
- ↑ Bert JS, Abdullah M, Dahle TG, Gertner E (2013). "Transcatheter aortic valve replacement for advanced valvular disease in active SLE and APS". Lupus. 22 (10): 1046–9. doi:10.1177/0961203313498797. PMID 23884983.
- ↑ Beales PL, Elcioglu N, Woolf AS, Parker D, Flinter FA (1999). "New criteria for improved diagnosis of Bardet-Biedl syndrome: results of a population survey". J Med Genet. 36 (6): 437–46. PMC 1734378. PMID 10874630.
- ↑ Nakao S, Takenaka T, Maeda M, Kodama C, Tanaka A, Tahara M; et al. (1995). "An atypical variant of Fabry's disease in men with left ventricular hypertrophy". N Engl J Med. 333 (5): 288–93. doi:10.1056/NEJM199508033330504. PMID 7596372.
- ↑ Sprecher DL, Schaefer EJ, Kent KM, Gregg RE, Zech LA, Hoeg JM; et al. (1984). "Cardiovascular features of homozygous familial hypercholesterolemia: analysis of 16 patients". Am J Cardiol. 54 (1): 20–30. PMID 6331147.
- ↑ Loscalzo ML, Goh DL, Loeys B, Kent KC, Spevak PJ, Dietz HC (2007). "Familial thoracic aortic dilation and bicommissural aortic valve: a prospective analysis of natural history and inheritance". Am J Med Genet A. 143A (17): 1960–7. doi:10.1002/ajmg.a.31872. PMID 17676603.
- ↑ REEVE, R.; ROBINSON, SJ. (1964). "HYPOPLASTIC ANNULUS--AN UNUSUAL TYPE OF AORTIC STENOSIS: A REPORT OF THREE CASES IN CHILDREN". Dis Chest. 45: 99–102. PMID 14114644. Unknown parameter
|month=
ignored (help) - ↑ "Subaortic stenosis short stature syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".
- ↑ Yamagishi Y, Yuda S, Tsuchihashi K, Saitoh S, Miura T, Ura N; et al. (2007). "Quadricuspid aortic valve associated with aortic stenosis and regurgitation: report of a case and a review of the literature". J Med Ultrason (2001). 34 (4): 197–200. doi:10.1007/s10396-007-0148-9. PMID 27278482.
- ↑ Feigenbaum A, Müller C, Yale C, Kleinheinz J, Jezewski P, Kehl HG; et al. (2013). "Singleton-Merten syndrome: an autosomal dominant disorder with variable expression". Am J Med Genet A. 161A (2): 360–70. doi:10.1002/ajmg.a.35732. PMID 23322711.
- ↑ Cohen PR, Kurzrock R (2003). "Sweet's syndrome revisited: a review of disease concepts". Int J Dermatol. 42 (10): 761–78. PMID 14521689.
- ↑ Bedynek JL, Galioto FM, Leon DF (2000). "Tricuspid aortic valve with partial commissural fusion: prelminary report of an apparently common cause of aortic ejection sounds with potential for serious sequelae, illustrated by two cases". Tex Heart Inst J. 27 (2): 201–5. PMC 101056. PMID 10928509.
- ↑ Noonan JA (1968). "Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease". Am J Dis Child. 116 (4): 373–80. PMID 4386970.
- ↑ 22.0 22.1 Kwon HJ, Park JH, Kim SS, Sun BJ, Jin SA, Kim JH; et al. (2016). "Severe Aortic Stenosis Associated with Unicommissural Unicuspid Aortic Valve in a Middle Aged Male". J Cardiovasc Ultrasound. 24 (3): 247–250. doi:10.4250/jcu.2016.24.3.247. PMC 5050315. PMID 27721957.
- ↑ Stern, JA.; Meurs, KM.; Nelson, OL.; Lahmers, SM.; Lehmkuhl, LB. (2012). "Familial subvalvular aortic stenosis in golden retrievers: inheritance and echocardiographic findings". J Small Anim Pract. 53 (4): 213–6. doi:10.1111/j.1748-5827.2011.01187.x. PMID 22417094. Unknown parameter
|month=
ignored (help) - ↑ Varma PK, Neema PK (2014). "Hypertrophic cardiomyopathy: part 1 - introduction, pathology and pathophysiology". Ann Card Anaesth. 17 (2): 118–24. doi:10.4103/0971-9784.129841. PMID 24732610.
- ↑ Clark CE, Henry WL, Epstein SE (1973). "Familial prevalence and genetic transmission of idiopathic hypertrophic subaortic stenosis". N Engl J Med. 289 (14): 709–14. doi:10.1056/NEJM197310042891402. PMID 4737963.
- ↑ Sharma S, Bahl VK, Rajani M (1997). "Stent treatment of obstructing dissection after percutaneous transluminal angioplasty of aortic stenosis caused by nonspecific aortitis". Cardiovasc Intervent Radiol. 20 (5): 377–9. PMID 9271649.
- ↑ Chiarella, F.; Bricarelli, FD.; Lupi, G.; Bellotti, P.; Domenicucci, S.; Vecchio, C. (1989). "Familial supravalvular aortic stenosis: a genetic study". J Med Genet. 26 (2): 86–92. PMID 2918546. Unknown parameter
|month=
ignored (help) - ↑ Giannakoulas, G.; Mouratoglou, SA.; Kelekis, A.; Hatzimiltiades, S.; Karvounis, H. "Supravalvular aortic stenosis in homozygous familial hypercholesterolemia". Hellenic J Cardiol. 54 (5): 392–3. PMID 24100183.
- ↑ Norwood WI, Lang P, Casteneda AR, Campbell DN (1981). "Experience with operations for hypoplastic left heart syndrome". J Thorac Cardiovasc Surg. 82 (4): 511–9. PMID 6168869.
- ↑ Deo, SV.; Burkhart, HM.; Dearani, JA.; Schaff, HV. (2013). "Supravalvar aortic stenosis: current surgical approaches and outcomes". Expert Rev Cardiovasc Ther. 11 (7): 879–90. doi:10.1586/14779072.2013.811967. PMID 23895031. Unknown parameter
|month=
ignored (help) - ↑ Morris CA, Demsey SA, Leonard CO, Dilts C, Blackburn BL (1988). "Natural history of Williams syndrome: physical characteristics". J Pediatr. 113 (2): 318–26. PMID 2456379.
- ↑ Siu SC, Silversides CK (2010). "Bicuspid aortic valve disease". J Am Coll Cardiol. 55 (25): 2789–800. doi:10.1016/j.jacc.2009.12.068. PMID 20579534.
- ↑ Kumar RK, Tandon R (2013). "Rheumatic fever & rheumatic heart disease: the last 50 years". Indian J Med Res. 137 (4): 643–58. PMC 3724245. PMID 23703332.
- ↑ 34.0 34.1 Pawade TA, Newby DE, Dweck MR (2015). "Calcification in Aortic Stenosis: The Skeleton Key". J Am Coll Cardiol. 66 (5): 561–77. doi:10.1016/j.jacc.2015.05.066. PMID 26227196.
- ↑ 35.0 35.1 Philip F, Faza NN, Schoenhagen P, Desai MY, Tuzcu EM, Svensson LG; et al. (2015). "Aortic annulus and root characteristics in severe aortic stenosis due to bicuspid aortic valve and tricuspid aortic valves: implications for transcatheter aortic valve therapies". Catheter Cardiovasc Interv. 86 (2): E88–98. doi:10.1002/ccd.25948. PMID 25914355.
- ↑ Marijon E, Mirabel M, Celermajer DS, Jouven X (2012). "Rheumatic heart disease". Lancet. 379 (9819): 953–64. doi:10.1016/S0140-6736(11)61171-9. PMID 22405798.