Blue rubber bleb nevus syndrome medical therapy: Difference between revisions

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== Medical Therapy ==
== Medical Therapy ==
* Pharmacologic medical therapies for [[blue rubber bleb nevus syndrome]] include:<ref name="pmid19958301">{{cite journal |vauthors=Agnese M, Cipolletta L, Bianco MA, Quitadamo P, Miele E, Staiano A |title=Blue rubber bleb nevus syndrome |journal=Acta Paediatr. |volume=99 |issue=4 |pages=632–5 |date=April 2010 |pmid=19958301 |doi=10.1111/j.1651-2227.2009.01608.x |url=}}</ref><ref name="pmid9795507">{{cite journal |vauthors=Jain A, Kar P, Chander R, Khandpur S, Jain S, Prabhash K, Gangwal P |title=Blue rubber bleb nevus syndrome: a cause of gastrointestinal hemorrhage |journal=Indian J Gastroenterol |volume=17 |issue=4 |pages=153–4 |date=1998 |pmid=9795507 |doi= |url=}}</ref><ref name="Jin2014">{{cite journal|last1=Jin|first1=Xue-Li|title=Blue rubber bleb nevus syndrome: A case report and literature review|journal=World Journal of Gastroenterology|volume=20|issue=45|year=2014|pages=17254|issn=1007-9327|doi=10.3748/wjg.v20.i45.17254}}</ref><ref name="BoenteCordisco1999">{{cite journal|last1=Boente|first1=Maria del C.|last2=Cordisco|first2=Maria R.|last3=Frontini|first3=Maria del V.|last4=Asial|first4=Raul A.|title=Blue Rubber Bleb Nevus (Bean Syndrome): Evolution of Four Cases and Clinical Response to Pharmacologic Agents|journal=Pediatric Dermatology|volume=16|issue=3|year=1999|pages=222–227|issn=0736-8046|doi=10.1046/j.1525-1470.1999.00065.x}}</ref><ref name="OguAbusin2018">{{cite journal|last1=Ogu|first1=Ugochi O.|last2=Abusin|first2=Ghada|last3=Abu-Arja|first3=Rolla F.|last4=Staber|first4=Janice M.|title=Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus|journal=Case Reports in Pediatrics|volume=2018|year=2018|pages=1–5|issn=2090-6803|doi=10.1155/2018/7654278}}</ref>
* Pharmacologic medical therapies for [[blue rubber bleb nevus syndrome]] include:<ref name="pmid19958301">{{cite journal |vauthors=Agnese M, Cipolletta L, Bianco MA, Quitadamo P, Miele E, Staiano A |title=Blue rubber bleb nevus syndrome |journal=Acta Paediatr. |volume=99 |issue=4 |pages=632–5 |date=April 2010 |pmid=19958301 |doi=10.1111/j.1651-2227.2009.01608.x |url=}}</ref><ref name="pmid9795507">{{cite journal |vauthors=Jain A, Kar P, Chander R, Khandpur S, Jain S, Prabhash K, Gangwal P |title=Blue rubber bleb nevus syndrome: a cause of gastrointestinal hemorrhage |journal=Indian J Gastroenterol |volume=17 |issue=4 |pages=153–4 |date=1998 |pmid=9795507 |doi= |url=}}</ref><ref name="Jin2014">{{cite journal|last1=Jin|first1=Xue-Li|title=Blue rubber bleb nevus syndrome: A case report and literature review|journal=World Journal of Gastroenterology|volume=20|issue=45|year=2014|pages=17254|issn=1007-9327|doi=10.3748/wjg.v20.i45.17254}}</ref><ref name="BoenteCordisco1999">{{cite journal|last1=Boente|first1=Maria del C.|last2=Cordisco|first2=Maria R.|last3=Frontini|first3=Maria del V.|last4=Asial|first4=Raul A.|title=Blue Rubber Bleb Nevus (Bean Syndrome): Evolution of Four Cases and Clinical Response to Pharmacologic Agents|journal=Pediatric Dermatology|volume=16|issue=3|year=1999|pages=222–227|issn=0736-8046|doi=10.1046/j.1525-1470.1999.00065.x}}</ref><ref name="OguAbusin2018">{{cite journal|last1=Ogu|first1=Ugochi O.|last2=Abusin|first2=Ghada|last3=Abu-Arja|first3=Rolla F.|last4=Staber|first4=Janice M.|title=Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus|journal=Case Reports in Pediatrics|volume=2018|year=2018|pages=1–5|issn=2090-6803|doi=10.1155/2018/7654278}}</ref>
** Preferred regimen (1):[[Interferon-beta]], 1.2 mg/m<sup>2</sup>/day for 2 month
** Preferred regimen (1): [[Interferon-beta]], 1.2 mg/m<sup>2</sup>/day for 2 month
** Preferred regimen (2):[[Octreotide]], 5.7 microg/kg subcutaneously twice daily for 4 weeks<ref name="pmid11568521">{{cite journal |vauthors=Gonzalez D, Elizondo BJ, Haslag S, Buchanan G, Burdick JS, Guzzetta PC, Hicks BA, Andersen JM |title=Chronic subcutaneous octreotide decreases gastrointestinal blood loss in blue rubber-bleb nevus syndrome |journal=J. Pediatr. Gastroenterol. Nutr. |volume=33 |issue=2 |pages=183–8 |date=August 2001 |pmid=11568521 |doi= |url=}}</ref>
** Preferred regimen (2): [[Octreotide]], 5.7 microg/kg [[Subcutaneous|subcutaneously]] twice daily for 4 weeks<ref name="pmid11568521">{{cite journal |vauthors=Gonzalez D, Elizondo BJ, Haslag S, Buchanan G, Burdick JS, Guzzetta PC, Hicks BA, Andersen JM |title=Chronic subcutaneous octreotide decreases gastrointestinal blood loss in blue rubber-bleb nevus syndrome |journal=J. Pediatr. Gastroenterol. Nutr. |volume=33 |issue=2 |pages=183–8 |date=August 2001 |pmid=11568521 |doi= |url=}}</ref>
** Preferred regimen (3):[[Sirolimus]],1.2 mg/m<sup>2</sup>/day for 2 months  <ref name="pmid27820137">{{cite journal |vauthors=Ünlüsoy Aksu A, Sari S, Eğritaş Gürkan Ö, Dalgiç B |title=Favorable Response to Sirolimus in a Child With Blue Rubber Bleb Nevus Syndrome in the Gastrointestinal Tract |journal=J. Pediatr. Hematol. Oncol. |volume=39 |issue=2 |pages=147–149 |date=March 2017 |pmid=27820137 |doi=10.1097/MPH.0000000000000681 |url=}}</ref>
** Preferred regimen (3): [[Sirolimus]],1.2 mg/m<sup>2</sup>/day for 2 months  <ref name="pmid27820137">{{cite journal |vauthors=Ünlüsoy Aksu A, Sari S, Eğritaş Gürkan Ö, Dalgiç B |title=Favorable Response to Sirolimus in a Child With Blue Rubber Bleb Nevus Syndrome in the Gastrointestinal Tract |journal=J. Pediatr. Hematol. Oncol. |volume=39 |issue=2 |pages=147–149 |date=March 2017 |pmid=27820137 |doi=10.1097/MPH.0000000000000681 |url=}}</ref>
** Preferred regimen (4):[[Iron]] supplementation  
** Preferred regimen (4): [[Iron]] supplementation
** Preferred regimen (5):[[Blood transfusions]]
** Preferred regimen (5): [[Blood transfusions]]
** Preferred regimen (6):[[Corticosteroids]]
** Preferred regimen (6): [[Corticosteroids]]
** Preferred regimen (7):[[Propranolol]], 40 mg twice daily; titrate weekly as needed based on patient response
** Preferred regimen (7): [[Propranolol]], 40 mg twice daily; [[titrate]] weekly as needed based on [[patient]] response
** Preferred regimen (8):[[Thalidomide]]
** Preferred regimen (8): [[Thalidomide]]
{{Blue rubber bleb nevus syndrome}}
{{Blue rubber bleb nevus syndrome}}
==References==
==References==

Latest revision as of 23:18, 27 January 2020

Blue rubber bleb nevus syndrome Microchapters

Home

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Blue Rubber Bleb Nevus Syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

CT

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Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

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Secondary Prevention

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Future or Investigational Therapies

Case Studies

Case #1

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US National Guidelines Clearinghouse

NICE Guidance

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Directions to Hospitals Treating Blue rubber bleb nevus syndrome

Risk calculators and risk factors for Blue rubber bleb nevus syndrome medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Vamsikrishna Gunnam M.B.B.S [2]

Overview

The mainstay of treatment for blue rubber bleb nevus syndrome is interferon-beta, octreotide, iron supplementation and blood transfusions.

Medical Therapy

Blue rubber bleb nevus syndrome Microchapters

Home

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Blue Rubber Bleb Nevus Syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Blue rubber bleb nevus syndrome medical therapy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Blue rubber bleb nevus syndrome medical therapy

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Blue rubber bleb nevus syndrome medical therapy

CDC on Blue rubber bleb nevus syndrome medical therapy

Blue rubber bleb nevus syndrome medical therapy in the news

Blogs on Blue rubber bleb nevus syndrome medical therapy

Directions to Hospitals Treating Blue rubber bleb nevus syndrome

Risk calculators and risk factors for Blue rubber bleb nevus syndrome medical therapy

References

  1. Agnese M, Cipolletta L, Bianco MA, Quitadamo P, Miele E, Staiano A (April 2010). "Blue rubber bleb nevus syndrome". Acta Paediatr. 99 (4): 632–5. doi:10.1111/j.1651-2227.2009.01608.x. PMID 19958301.
  2. Jain A, Kar P, Chander R, Khandpur S, Jain S, Prabhash K, Gangwal P (1998). "Blue rubber bleb nevus syndrome: a cause of gastrointestinal hemorrhage". Indian J Gastroenterol. 17 (4): 153–4. PMID 9795507.
  3. Jin, Xue-Li (2014). "Blue rubber bleb nevus syndrome: A case report and literature review". World Journal of Gastroenterology. 20 (45): 17254. doi:10.3748/wjg.v20.i45.17254. ISSN 1007-9327.
  4. Boente, Maria del C.; Cordisco, Maria R.; Frontini, Maria del V.; Asial, Raul A. (1999). "Blue Rubber Bleb Nevus (Bean Syndrome): Evolution of Four Cases and Clinical Response to Pharmacologic Agents". Pediatric Dermatology. 16 (3): 222–227. doi:10.1046/j.1525-1470.1999.00065.x. ISSN 0736-8046.
  5. Ogu, Ugochi O.; Abusin, Ghada; Abu-Arja, Rolla F.; Staber, Janice M. (2018). "Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus". Case Reports in Pediatrics. 2018: 1–5. doi:10.1155/2018/7654278. ISSN 2090-6803.
  6. Gonzalez D, Elizondo BJ, Haslag S, Buchanan G, Burdick JS, Guzzetta PC, Hicks BA, Andersen JM (August 2001). "Chronic subcutaneous octreotide decreases gastrointestinal blood loss in blue rubber-bleb nevus syndrome". J. Pediatr. Gastroenterol. Nutr. 33 (2): 183–8. PMID 11568521.
  7. Ünlüsoy Aksu A, Sari S, Eğritaş Gürkan Ö, Dalgiç B (March 2017). "Favorable Response to Sirolimus in a Child With Blue Rubber Bleb Nevus Syndrome in the Gastrointestinal Tract". J. Pediatr. Hematol. Oncol. 39 (2): 147–149. doi:10.1097/MPH.0000000000000681. PMID 27820137.

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