Osteoglycin: Difference between revisions

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m (Neodop moved page OGN (gene) to Osteoglycin over redirect: Full name per HGNC.)
 
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This gene encodes a protein which induces ectopic bone formation in conjunction with [[transforming growth factor]] [[TGF-beta|beta]]. This protein is a small proteoglycan which contains tandem [[leucine]]-rich repeats (LRR). The gene expresses [[alternative splicing|three transcript]] variants.<ref name="entrez" />
This gene encodes a protein which induces ectopic bone formation in conjunction with [[transforming growth factor]] [[TGF-beta|beta]]. This protein is a small proteoglycan which contains tandem [[leucine]]-rich repeats (LRR). The gene expresses [[alternative splicing|three transcript]] variants.<ref name="entrez" />


The level of expression of this gene has been correlated with [[enlarged heart]]s and more specifically [[left ventricular hypertrophy]].<ref name="urlBBC NEWS" | Health | Big hearts have genetic problem">{{cite web | url = http://news.bbc.co.uk/2/hi/health/7371213.stm | title = Big hearts 'have genetic problem' | date = 2008-06-06 | format = | work = Health | publisher = BBC News | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2008-06-07}}</ref><ref name="pmid18443592">{{cite journal |vauthors=Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA | title = Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass | journal = Nat. Genet. | volume = 40 | issue = 5 | pages = 546–52 |date=May 2008 | pmid = 18443592 | doi = 10.1038/ng.134 | url = | pmc = 2742198 }}</ref>
The level of expression of this gene has been correlated with [[enlarged heart]]s and more specifically [[left ventricular hypertrophy]].<ref name="Big hearts have genetic problem">{{cite web | url = http://news.bbc.co.uk/2/hi/health/7371213.stm | title = Big hearts 'have genetic problem' | date = 2008-06-06 | format = | work = Health | publisher = BBC News | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2008-06-07}}</ref><ref name="pmid18443592">{{cite journal |vauthors=Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA | title = Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass | journal = Nat. Genet. | volume = 40 | issue = 5 | pages = 546–52 |date=May 2008 | pmid = 18443592 | doi = 10.1038/ng.134 | url = | pmc = 2742198 }}</ref>


==References==
==References==

Latest revision as of 14:07, 11 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein.[1]

This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.[1]

The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy.[2][3]

References

  1. 1.0 1.1 "Entrez Gene: OGN osteoglycin".
  2. "Big hearts 'have genetic problem'". Health. BBC News. 2008-06-06. Retrieved 2008-06-07.
  3. Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008). "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. doi:10.1038/ng.134. PMC 2742198. PMID 18443592.

Further reading