SEPT6: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Septin-6''' is a [[protein]] that in humans is encoded by the ''SEPT6'' [[gene]].<ref name="pmid8590280">{{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 4 | pages = 167–74, 199–210 | date = August 1995 | pmid = 8590280 | pmc =  | doi = 10.1093/dnares/2.4.167 }}</ref><ref name="pmid10744683">{{cite journal | vauthors = Xue J, Wang X, Malladi CS, Kinoshita M, Milburn PJ, Lengyel I, Rostas JA, Robinson PJ | title = Phosphorylation of a new brain-specific septin, G-septin, by cGMP-dependent protein kinase | journal = The Journal of Biological Chemistry | volume = 275 | issue = 14 | pages = 10047–56 | date = April 2000 | pmid = 10744683 | pmc =  | doi = 10.1074/jbc.275.14.10047 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SEPT6 septin 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23157| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Septin 6
| HGNCid = 15848
| Symbol = SEPT6
| AltSymbols =; KIAA0128; MGC16619; MGC20339; SEP2
| OMIM = 
| ECnumber = 
| Homologene = 62617
| MGIid = 1888939
| GeneAtlas_image1 = PBB_GE_SEPT6_212413_at_tn.png
| GeneAtlas_image2 = PBB_GE_SEPT6_212414_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SEPT6_213666_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0000910 |text = cytokinesis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23157
    | Hs_Ensembl = ENSG00000125354
    | Hs_RefseqProtein = NP_055944
    | Hs_RefseqmRNA = NM_015129
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 118633718
    | Hs_GenLoc_end = 118711361
    | Hs_Uniprot = Q14141
    | Mm_EntrezGene = 56526
    | Mm_Ensembl = ENSMUSG00000050379
    | Mm_RefseqmRNA = NM_019942
    | Mm_RefseqProtein = NP_064326
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 33343690
    | Mm_GenLoc_end = 33420921
    | Mm_Uniprot = Q3TRH9
  }}
}}
'''Septin 6''', also known as '''SEPT6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEPT6 septin 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23157| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the [[septin]] family of [[GTPase]]s. Members of this family are required for [[cytokinesis]]. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: SEPT6 septin 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23157| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}
 
==Further reading==
One version of pediatric [[acute myeloid leukemia]] is the result of a [[Chromosomal translocation#Reciprocal translocations|reciprocal translocation]] between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins.<ref name="entrez"/>
 
== Interactions ==
 
SEPT6 has been shown to [[Protein-protein interaction|interact]] with [[SEPT2]].<ref name = pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name = pmid12388755>{{cite journal | vauthors = Surka MC, Tsang CW, Trimble WS | title = The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis | journal = Molecular Biology of the Cell | volume = 13 | issue = 10 | pages = 3532–45 | date = October 2002 | pmid = 12388755 | pmc = 129964 | doi = 10.1091/mbc.E02-01-0042 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kinoshita A, Noda M, Kinoshita M | title = Differential localization of septins in the mouse brain | journal = The Journal of Comparative Neurology | volume = 428 | issue = 2 | pages = 223–39 | date = December 2000 | pmid = 11064363 | doi = 10.1002/1096-9861(20001211)428:2<223::AID-CNE3>3.0.CO;2-M }}
| citations =
* {{cite journal | vauthors = Ono R, Taki T, Taketani T, Kawaguchi H, Taniwaki M, Okamura T, Kawa K, Hanada R, Kobayashi M, Hayashi Y | title = SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24 | journal = Cancer Research | volume = 62 | issue = 2 | pages = 333–7 | date = January 2002 | pmid = 11809673 | doi =  }}
*{{cite journal | author=Nagase T, Seki N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167-74, 199-210 |year= 1996 |pmid= 8590280 |doi=  }}
* {{cite journal | vauthors = Slater DJ, Hilgenfeld E, Rappaport EF, Shah N, Meek RG, Williams WR, Lovett BD, Osheroff N, Autar RS, Ried T, Felix CA | title = MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site | journal = Oncogene | volume = 21 | issue = 30 | pages = 4706–14 | date = July 2002 | pmid = 12096348 | doi = 10.1038/sj.onc.1205572 }}
*{{cite journal  | author=Xue J, Wang X, Malladi CS, ''et al.'' |title=Phosphorylation of a new brain-specific septin, G-septin, by cGMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10047-56 |year= 2000 |pmid= 10744683 |doi=  }}
* {{cite journal | vauthors = Surka MC, Tsang CW, Trimble WS | title = The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis | journal = Molecular Biology of the Cell | volume = 13 | issue = 10 | pages = 3532–45 | date = October 2002 | pmid = 12388755 | pmc = 129964 | doi = 10.1091/mbc.E02-01-0042 }}
*{{cite journal  | author=Kinoshita A, Noda M, Kinoshita M |title=Differential localization of septins in the mouse brain. |journal=J. Comp. Neurol. |volume=428 |issue= 2 |pages= 223-39 |year= 2000 |pmid= 11064363 |doi= }}
* {{cite journal | vauthors = Sheffield PJ, Oliver CJ, Kremer BE, Sheng S, Shao Z, Macara IG | title = Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments | journal = The Journal of Biological Chemistry | volume = 278 | issue = 5 | pages = 3483–8 | date = January 2003 | pmid = 12446710 | doi = 10.1074/jbc.M209701200 }}
*{{cite journal | author=Ono R, Taki T, Taketani T, ''et al.'' |title=SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24. |journal=Cancer Res. |volume=62 |issue= 2 |pages= 333-7 |year= 2002 |pmid= 11809673 |doi=  }}
* {{cite journal | vauthors = Vega IE, Hsu SC | title = The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells | journal = NeuroReport | volume = 14 | issue = 1 | pages = 31–7 | date = January 2003 | pmid = 12544826 | doi = 10.1097/00001756-200301200-00006}}
*{{cite journal | author=Slater DJ, Hilgenfeld E, Rappaport EF, ''et al.'' |title=MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site. |journal=Oncogene |volume=21 |issue= 30 |pages= 4706-14 |year= 2002 |pmid= 12096348 |doi= 10.1038/sj.onc.1205572 }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566–9 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 }}
*{{cite journal | author=Surka MC, Tsang CW, Trimble WS |title=The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis. |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3532-45 |year= 2003 |pmid= 12388755 |doi= 10.1091/mbc.E02-01-0042 }}
* {{cite journal | vauthors = Koshelev YA, Kiselev SL, Georgiev GP | title = Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro | journal = Doklady Biochemistry and Biophysics | volume = 391 | issue =  | pages = 195–7 | year = 2004 | pmid = 14531065 | doi = 10.1023/A:1025149005902 }}
*{{cite journal | author=Sheffield PJ, Oliver CJ, Kremer BE, ''et al.'' |title=Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3483-8 |year= 2003 |pmid= 12446710 |doi= 10.1074/jbc.M209701200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kadkol SS, Bruno A, Oh S, Schmidt ML, Lindgren V | title = MLL-SEPT6 fusion transcript with a novel sequence in an infant with acute myeloid leukemia | journal = Cancer Genetics and Cytogenetics | volume = 168 | issue = 2 | pages = 162–7 | date = July 2006 | pmid = 16843108 | doi = 10.1016/j.cancergencyto.2006.02.020 }}
*{{cite journal  | author=Vega IE, Hsu SC |title=The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells. |journal=Neuroreport |volume=14 |issue= 1 |pages= 31-7 |year= 2003 |pmid= 12544826 |doi= 10.1097/01.wnr.0000050304.92401.50 }}
* {{cite journal | vauthors = Low C, Macara IG | title = Structural analysis of septin 2, 6, and 7 complexes | journal = The Journal of Biological Chemistry | volume = 281 | issue = 41 | pages = 30697–706 | date = October 2006 | pmid = 16914550 | doi = 10.1074/jbc.M605179200 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
* {{cite journal | vauthors = Kim CS, Seol SK, Song OK, Park JH, Jang SK | title = An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication | journal = Journal of Virology | volume = 81 | issue = 8 | pages = 3852–65 | date = April 2007 | pmid = 17229681 | pmc = 1866118 | doi = 10.1128/JVI.01311-06 }}
*{{cite journal | author=Koshelev YA, Kiselev SL, Georgiev GP |title=Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro. |journal=Dokl. Biochem. Biophys. |volume=391 |issue=  |pages= 195-7 |year= 2004 |pmid= 14531065 |doi= }}
* {{cite journal | vauthors = Sirajuddin M, Farkasovsky M, Hauer F, Kühlmann D, Macara IG, Weyand M, Stark H, Wittinghofer A | title = Structural insight into filament formation by mammalian septins | journal = Nature | volume = 449 | issue = 7160 | pages = 311–5 | date = September 2007 | pmid = 17637674 | doi = 10.1038/nature06052 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Kremer BE, Adang LA, Macara IG | title = Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7 | journal = Cell | volume = 130 | issue = 5 | pages = 837–50 | date = September 2007 | pmid = 17803907 | pmc = 2085444 | doi = 10.1016/j.cell.2007.06.053 }}
*{{cite journal  | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Kadkol SS, Bruno A, Oh S, ''et al.'' |title=MLL-SEPT6 fusion transcript with a novel sequence in an infant with acute myeloid leukemia. |journal=Cancer Genet. Cytogenet. |volume=168 |issue= 2 |pages= 162-7 |year= 2006 |pmid= 16843108 |doi= 10.1016/j.cancergencyto.2006.02.020 }}
*{{cite journal | author=Low C, Macara IG |title=Structural analysis of septin 2, 6, and 7 complexes. |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 30697-706 |year= 2006 |pmid= 16914550 |doi= 10.1074/jbc.M605179200 }}
*{{cite journal | author=Kim CS, Seol SK, Song OK, ''et al.'' |title=An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. |journal=J. Virol. |volume=81 |issue= 8 |pages= 3852-65 |year= 2007 |pmid= 17229681 |doi= 10.1128/JVI.01311-06 }}
*{{cite journal | author=Sirajuddin M, Farkasovsky M, Hauer F, ''et al.'' |title=Structural insight into filament formation by mammalian septins. |journal=Nature |volume=449 |issue= 7160 |pages= 311-5 |year= 2007 |pmid= 17637674 |doi= 10.1038/nature06052 }}
*{{cite journal | author=Kremer BE, Adang LA, Macara IG |title=Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. |journal=Cell |volume=130 |issue= 5 |pages= 837-50 |year= 2007 |pmid= 17803907 |doi= 10.1016/j.cell.2007.06.053 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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Latest revision as of 19:56, 31 March 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Septin-6 is a protein that in humans is encoded by the SEPT6 gene.[1][2][3]

Function

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.[3]

Clinical significance

One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins.[3]

Interactions

SEPT6 has been shown to interact with SEPT2.[4][5]

References

  1. ↑ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
  2. ↑ Xue J, Wang X, Malladi CS, Kinoshita M, Milburn PJ, Lengyel I, Rostas JA, Robinson PJ (April 2000). "Phosphorylation of a new brain-specific septin, G-septin, by cGMP-dependent protein kinase". The Journal of Biological Chemistry. 275 (14): 10047–56. doi:10.1074/jbc.275.14.10047. PMID 10744683.
  3. ↑ 3.0 3.1 3.2 "Entrez Gene: SEPT6 septin 6".
  4. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  5. ↑ Surka MC, Tsang CW, Trimble WS (October 2002). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis". Molecular Biology of the Cell. 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMC 129964. PMID 12388755.

Further reading


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