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{{Infobox_gene}}
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'''Ski-like protein''' is a [[protein]] that in humans is encoded by the ''SKIL'' [[gene]].<ref name="pmid2762147">{{cite journal |author1=Nomura N |author2=Sasamoto S |author3=Ishii S |author4=Date T |author5=Matsui M |author6=Ishizaki R | title = Isolation of human cDNA clones of ski and the ski-related gene, sno | journal = Nucleic Acids Res | volume = 17 | issue = 14 | pages = 5489–500 |date=September 1989 | pmid = 2762147 | pmc = 318172 | doi =10.1093/nar/17.14.5489 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SKIL SKI-like oncogene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6498| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source =
| PDB =  
| Name = SKI-like oncogene
| HGNCid = 10897
| Symbol = SKIL
| AltSymbols =; SNO; SnoA; SnoN
| OMIM = 165340
| ECnumber = 
| Homologene = 3948
| MGIid = 106203
| GeneAtlas_image1 = PBB_GE_SKIL_206675_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005072 |text = transforming growth factor beta receptor, cytoplasmic mediator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6498
    | Hs_Ensembl = ENSG00000136603
    | Hs_RefseqProtein = NP_005405
    | Hs_RefseqmRNA = NM_005414
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 171560814
    | Hs_GenLoc_end = 171593226
    | Hs_Uniprot = P12757
    | Mm_EntrezGene = 20482
    | Mm_Ensembl = ENSMUSG00000027660
    | Mm_RefseqmRNA = NM_001039090
    | Mm_RefseqProtein = NP_001034179
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 31288209
    | Mm_GenLoc_end = 31313455
    | Mm_Uniprot = Q3TQJ9
  }}
}}
'''SKI-like oncogene''', also known as '''SKIL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SKIL SKI-like oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6498| accessdate = }}</ref>


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==Interactions==
SKIL has been shown to [[Protein-protein interaction|interact]] with [[SKI protein]],<ref name=pmid9927733>{{cite journal |doi=10.1093/nar/27.4.1006 |last=Cohen |first=S B |authorlink= |author2=Zheng G |author3=Heyman H C |author4=Stavnezer E  |date=February 1999 |title=Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents |journal=Nucleic Acids Res. |volume=27 |issue=4 |pages=1006–14 |publisher= |location = ENGLAND| issn = 0305-1048| pmid = 9927733 |pmc=148280 }}</ref> [[Mothers against decapentaplegic homolog 3]]<ref name=pmid11691834>{{cite journal |last=Stroschein |first=S L |authorlink= |author2=Bonni S |author3=Wrana J L |author4=Luo K  |date=November 2001 |title=Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN |journal=Genes Dev. |volume=15 |issue=21 |pages=2822–36 |publisher= |location = United States| issn = 0890-9369| pmid = 11691834 |doi = 10.1101/gad.912901| bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=312804 }}</ref><ref name=pmid10531062>{{cite journal |doi=10.1126/science.286.5440.771 |last=Stroschein |first=S L |authorlink= |author2=Wang W |author3=Zhou S |author4=Zhou Q |author5=Luo K  |date=October 1999 |title=Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein |journal=[[Science (journal)|Science]] |volume=286 |issue=5440 |pages=771–4 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 10531062  |url=https://zenodo.org/record/1231169/files/article.pdf}}</ref> and [[Mothers against decapentaplegic homolog 2]].<ref name=pmid11691834/><ref name=pmid10531062/>


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Nomura N, Sasamoto S, Ishii S, ''et al.'' |title=Isolation of human cDNA clones of ski and the ski-related gene, sno. |journal=Nucleic Acids Res. |volume=17 |issue= 14 |pages= 5489-500 |year= 1989 |pmid= 2762147 |doi=  }}
*{{cite journal  | author=Pearson-White S |title=SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno |journal=Nucleic Acids Res. |volume=21 |issue= 19 |pages= 4632–8 |year= 1993 |pmid= 8233802 |doi=10.1093/nar/21.19.4632  | pmc=311202 }}
*{{cite journal  | author=Pearson-White S |title=SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno. |journal=Nucleic Acids Res. |volume=21 |issue= 19 |pages= 4632-8 |year= 1993 |pmid= 8233802 |doi=  }}
*{{cite journal  |author1=Pearson-White S |author2=Crittenden R |title=Proto-oncogene Sno expression, alternative isoforms and immediate early serum response |journal=Nucleic Acids Res. |volume=25 |issue= 14 |pages= 2930–7 |year= 1997 |pmid= 9207045 |doi=10.1093/nar/25.14.2930  | pmc=146803 }}
*{{cite journal  | author=Pearson-White S, Crittenden R |title=Proto-oncogene Sno expression, alternative isoforms and immediate early serum response. |journal=Nucleic Acids Res. |volume=25 |issue= 14 |pages= 2930-7 |year= 1997 |pmid= 9207045 |doi=  }}
*{{cite journal  |author1=Cohen SB |author2=Zheng G |author3=Heyman HC |author4=Stavnezer E |title=Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents |journal=Nucleic Acids Res. |volume=27 |issue= 4 |pages= 1006–14 |year= 1999 |pmid= 9927733 |doi=10.1093/nar/27.4.1006 | pmc=148280  }}
*{{cite journal | author=Cohen SB, Zheng G, Heyman HC, Stavnezer E |title=Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents. |journal=Nucleic Acids Res. |volume=27 |issue= 4 |pages= 1006-14 |year= 1999 |pmid= 9927733 |doi=  }}
*{{cite journal   |vauthors=Stroschein SL, Wang W, Zhou S, etal |title=Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein |journal=Science |volume=286 |issue= 5440 |pages= 771–4 |year= 1999 |pmid= 10531062 |doi=10.1126/science.286.5440.771 }}
*{{cite journal | author=Stroschein SL, Wang W, Zhou S, ''et al.'' |title=Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. |journal=Science |volume=286 |issue= 5440 |pages= 771-4 |year= 1999 |pmid= 10531062 |doi= }}
*{{cite journal   |vauthors=Bonni S, Wang HR, Causing CG, etal |title=TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation |journal=Nat. Cell Biol. |volume=3 |issue= 6 |pages= 587–95 |year= 2001 |pmid= 11389444 |doi= 10.1038/35078562 }}
*{{cite journal | author=Bonni S, Wang HR, Causing CG, ''et al.'' |title=TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. |journal=Nat. Cell Biol. |volume=3 |issue= 6 |pages= 587-95 |year= 2001 |pmid= 11389444 |doi= 10.1038/35078562 }}
*{{cite journal   |vauthors=Imoto I, Pimkhaokham A, Fukuda Y, etal |title=SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 3 |pages= 559–65 |year= 2001 |pmid= 11511096 |doi= 10.1006/bbrc.2001.5428 }}
*{{cite journal  | author=Imoto I, Pimkhaokham A, Fukuda Y, ''et al.'' |title=SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 3 |pages= 559-65 |year= 2001 |pmid= 11511096 |doi= 10.1006/bbrc.2001.5428 }}
*{{cite journal  |author1=Stroschein SL |author2=Bonni S |author3=Wrana JL |author4=Luo K |title=Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN |journal=Genes Dev. |volume=15 |issue= 21 |pages= 2822–36 |year= 2001 |pmid= 11691834 |doi= 10.1101/gad.912901  | pmc=312804 }}
*{{cite journal | author=Stroschein SL, Bonni S, Wrana JL, Luo K |title=Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. |journal=Genes Dev. |volume=15 |issue= 21 |pages= 2822-36 |year= 2001 |pmid= 11691834 |doi= 10.1101/gad.912901 }}
*{{cite journal   |vauthors=Mizuide M, Hara T, Furuya T, etal |title=Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 531–6 |year= 2003 |pmid= 12426322 |doi= 10.1074/jbc.C200596200 }}
*{{cite journal | author=Mizuide M, Hara T, Furuya T, ''et al.'' |title=Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 531-6 |year= 2003 |pmid= 12426322 |doi= 10.1074/jbc.C200596200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |author1=Tomsig JL |author2=Snyder SL |author3=Creutz CE |title=Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10048–54 |year= 2003 |pmid= 12522145 |doi= 10.1074/jbc.M212632200 }}
*{{cite journal | author=Tomsig JL, Snyder SL, Creutz CE |title=Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10048-54 |year= 2003 |pmid= 12522145 |doi= 10.1074/jbc.M212632200 }}
*{{cite journal   |vauthors=He J, Tegen SB, Krawitz AR, etal |title=The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 30540–7 |year= 2003 |pmid= 12764135 |doi= 10.1074/jbc.M304016200 }}
*{{cite journal | author=He J, Tegen SB, Krawitz AR, ''et al.'' |title=The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 30540-7 |year= 2003 |pmid= 12764135 |doi= 10.1074/jbc.M304016200 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |author1=Sarker KP |author2=Wilson SM |author3=Bonni S |title=SnoN is a cell type-specific mediator of transforming growth factor-beta responses |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 13037–46 |year= 2005 |pmid= 15677458 |doi= 10.1074/jbc.M409367200 }}
*{{cite journal | author=Sarker KP, Wilson SM, Bonni S |title=SnoN is a cell type-specific mediator of transforming growth factor-beta responses. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 13037-46 |year= 2005 |pmid= 15677458 |doi= 10.1074/jbc.M409367200 }}
*{{cite journal   |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |bibcode=2005Sci...307.1621B }}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal   |vauthors=Poser I, Rothhammer T, Dooley S, etal |title=Characterization of Sno expression in malignant melanoma |journal=Int. J. Oncol. |volume=26 |issue= 5 |pages= 1411–7 |year= 2005 |pmid= 15809735 |doi= 10.3892/ijo.26.5.1411}}
*{{cite journal | author=Poser I, Rothhammer T, Dooley S, ''et al.'' |title=Characterization of Sno expression in malignant melanoma. |journal=Int. J. Oncol. |volume=26 |issue= 5 |pages= 1411-7 |year= 2005 |pmid= 15809735 |doi=  }}
*{{cite journal   |vauthors=Krakowski AR, Laboureau J, Mauviel A, etal |title=Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-β signaling by sequestration of the Smad proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 35 |pages= 12437–42 |year= 2005 |pmid= 16109768 |doi= 10.1073/pnas.0504107102 | pmc=1194926 |bibcode=2005PNAS..10212437K }}
*{{cite journal  | author=Krakowski AR, Laboureau J, Mauviel A, ''et al.'' |title=Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 35 |pages= 12437-42 |year= 2005 |pmid= 16109768 |doi= 10.1073/pnas.0504107102 }}
*{{cite journal  |author1=Zhu Q |author2=Pearson-White S |author3=Luo K |title=Requirement for the SnoN Oncoprotein in Transforming Growth Factor β-Induced Oncogenic Transformation of Fibroblast Cells |journal=Mol. Cell. Biol. |volume=25 |issue= 24 |pages= 10731–44 |year= 2006 |pmid= 16314499 |doi= 10.1128/MCB.25.24.10731-10744.2005 | pmc=1316959 }}
*{{cite journal | author=Zhu Q, Pearson-White S, Luo K |title=Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells. |journal=Mol. Cell. Biol. |volume=25 |issue= 24 |pages= 10731-44 |year= 2006 |pmid= 16314499 |doi= 10.1128/MCB.25.24.10731-10744.2005 }}
*{{cite journal   |vauthors=Briones-Orta MA, Sosa-Garrocho M, Moreno-Alvarez P, etal |title=SnoN co-repressor binds and represses smad7 gene promoter |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 3 |pages= 889–94 |year= 2006 |pmid= 16442497 |doi= 10.1016/j.bbrc.2006.01.041 }}
*{{cite journal | author=Briones-Orta MA, Sosa-Garrocho M, Moreno-Alvarez P, ''et al.'' |title=SnoN co-repressor binds and represses smad7 gene promoter. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 3 |pages= 889-94 |year= 2006 |pmid= 16442497 |doi= 10.1016/j.bbrc.2006.01.041 }}
}}
}}
{{refend}}
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Latest revision as of 05:45, 28 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Ski-like protein is a protein that in humans is encoded by the SKIL gene.[1][2]


Interactions

SKIL has been shown to interact with SKI protein,[3] Mothers against decapentaplegic homolog 3[4][5] and Mothers against decapentaplegic homolog 2.[4][5]

References

  1. ↑ Nomura N; Sasamoto S; Ishii S; Date T; Matsui M; Ishizaki R (September 1989). "Isolation of human cDNA clones of ski and the ski-related gene, sno". Nucleic Acids Res. 17 (14): 5489–500. doi:10.1093/nar/17.14.5489. PMC 318172. PMID 2762147.
  2. ↑ "Entrez Gene: SKIL SKI-like oncogene".
  3. ↑ Cohen, S B; Zheng G; Heyman H C; Stavnezer E (February 1999). "Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents". Nucleic Acids Res. ENGLAND. 27 (4): 1006–14. doi:10.1093/nar/27.4.1006. ISSN 0305-1048. PMC 148280. PMID 9927733.
  4. ↑ 4.0 4.1 Stroschein, S L; Bonni S; Wrana J L; Luo K (November 2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes Dev. United States. 15 (21): 2822–36. doi:10.1101/gad.912901. ISSN 0890-9369. PMC 312804. PMID 11691834.
  5. ↑ 5.0 5.1 Stroschein, S L; Wang W; Zhou S; Zhou Q; Luo K (October 1999). "Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein" (PDF). Science. UNITED STATES. 286 (5440): 771–4. doi:10.1126/science.286.5440.771. ISSN 0036-8075. PMID 10531062.

Further reading



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