RNF7: Difference between revisions

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{{Infobox_gene}}
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'''RING-box protein 2''' is a [[protein]] that in humans is encoded by the ''RNF7'' [[gene]].<ref name="pmid10082581">{{cite journal |vauthors=Duan H, Wang Y, Aviram M, Swaroop M, Loo JA, Bian J, Tian Y, Mueller T, Bisgaier CL, Sun Y | title = SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents | journal = Mol Cell Biol | volume = 19 | issue = 4 | pages = 3145–55 |date=April 1999 | pmid = 10082581 | pmc = 84108 | doi =  }}</ref><ref name="pmid10230407">{{cite journal |vauthors=Ohta T, Michel JJ, Schottelius AJ, Xiong Y | title = ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity | journal = Mol Cell | volume = 3 | issue = 4 | pages = 535–41 |date=May 1999 | pmid = 10230407 | pmc =  | doi =10.1016/S1097-2765(00)80482-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RNF7 ring finger protein 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9616| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ring finger protein 7
| HGNCid = 10070
| Symbol = RNF7
| AltSymbols =; ROC2; SAG; CKBBP1
| OMIM = 603863
| ECnumber =
| Homologene = 84476
| MGIid = 1337096
| GeneAtlas_image1 = PBB_GE_RNF7_218286_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006980 |text = redox signal response}} {{GNF_GO|id=GO:0008631 |text = induction of apoptosis by oxidative stress}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9616
    | Hs_Ensembl = ENSG00000114125
    | Hs_RefseqProtein = NP_055060
    | Hs_RefseqmRNA = NM_014245
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 142939741
    | Hs_GenLoc_end = 142947932
    | Hs_Uniprot = Q9UBF6
    | Mm_EntrezGene = 19823
    | Mm_Ensembl =   
    | Mm_RefseqmRNA = XM_905787
    | Mm_RefseqProtein = XP_910880
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start =   
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Ring finger protein 7''', also known as '''RNF7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNF7 ring finger protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9616| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: RNF7 ring finger protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9616| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez" />
}}
}}
==Interactions==
RNF7 has been shown to [[Protein-protein interaction|interact]] with [[CSNK2B]].<ref name=pmid11710515>{{cite journal |last=Ahn |first=B H |authorlink= |author2=Kim T H |author3=Bae Y S  |date=October 2001 |title=Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins |journal=Mol. Cells |volume=12 |issue=2 |pages=158–63 |publisher= |location = Korea (South)| issn = 1016-8478| pmid = 11710515 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==See also==
==See also==
Line 58: Line 15:


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal | author=Duan H, Wang Y, Aviram M, ''et al.'' |title=SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 3145-55 |year= 1999 |pmid= 10082581 |doi= }}
*{{cite journal   |vauthors=Tan P, Fuchs SY, Chen A, etal |title=Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha |journal=Mol. Cell |volume=3 |issue= 4 |pages= 527–33 |year= 1999 |pmid= 10230406 |doi=10.1016/S1097-2765(00)80481-5  }}
*{{cite journal | author=Tan P, Fuchs SY, Chen A, ''et al.'' |title=Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 527-33 |year= 1999 |pmid= 10230406 |doi= }}
*{{cite journal   |vauthors=Swaroop M, Bian J, Aviram M, etal |title=Expression, purification, and biochemical characterization of SAG, a ring finger redox-sensitive protein |journal=Free Radic. Biol. Med. |volume=27 |issue= 1–2 |pages= 193–202 |year= 1999 |pmid= 10443936 |doi=10.1016/S0891-5849(99)00078-7  }}
*{{cite journal  | author=Ohta T, Michel JJ, Schottelius AJ, Xiong Y |title=ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 535-41 |year= 1999 |pmid= 10230407 |doi=  }}
*{{cite journal  | author=Sun Y |title=Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection |journal=Carcinogenesis |volume=20 |issue= 10 |pages= 1899–903 |year= 1999 |pmid= 10506102 |doi=10.1093/carcin/20.10.1899 }}
*{{cite journal | author=Swaroop M, Bian J, Aviram M, ''et al.'' |title=Expression, purification, and biochemical characterization of SAG, a ring finger redox-sensitive protein. |journal=Free Radic. Biol. Med. |volume=27 |issue= 1-2 |pages= 193-202 |year= 1999 |pmid= 10443936 |doi= }}
*{{cite journal   |vauthors=Son MY, Park JW, Kim YS, etal |title=Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 3 |pages= 743–8 |year= 1999 |pmid= 10512750 |doi= 10.1006/bbrc.1999.1460 }}
*{{cite journal | author=Sun Y |title=Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection. |journal=Carcinogenesis |volume=20 |issue= 10 |pages= 1899-903 |year= 1999 |pmid= 10506102 |doi= }}
*{{cite journal   |vauthors=Chen A, Wu K, Fuchs SY, etal |title=The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15432–9 |year= 2000 |pmid= 10748083 |doi= 10.1074/jbc.M907300199 }}
*{{cite journal | author=Son MY, Park JW, Kim YS, ''et al.'' |title=Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 3 |pages= 743-8 |year= 1999 |pmid= 10512750 |doi= 10.1006/bbrc.1999.1460 }}
*{{cite journal   |vauthors=Swaroop M, Wang Y, Miller P, etal |title=Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation |journal=Oncogene |volume=19 |issue= 24 |pages= 2855–66 |year= 2000 |pmid= 10851089 |doi= 10.1038/sj.onc.1203635 }}
*{{cite journal | author=Chen A, Wu K, Fuchs SY, ''et al.'' |title=The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15432-9 |year= 2000 |pmid= 10748083 |doi= 10.1074/jbc.M907300199 }}
*{{cite journal   |vauthors=Furukawa M, Zhang Y, McCarville J, etal |title=The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1 |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 8185–97 |year= 2000 |pmid= 11027288 |doi=10.1128/MCB.20.21.8185-8197.2000  | pmc=86428  }}
*{{cite journal | author=Swaroop M, Wang Y, Miller P, ''et al.'' |title=Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. |journal=Oncogene |volume=19 |issue= 24 |pages= 2855-66 |year= 2000 |pmid= 10851089 |doi= 10.1038/sj.onc.1203635 }}
*{{cite journal   |vauthors=Duan H, Tsvetkov LM, Liu Y, etal |title=Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation |journal=Mol. Carcinog. |volume=30 |issue= 1 |pages= 37–46 |year= 2001 |pmid= 11255262 |doi=10.1002/1098-2744(200101)30:1<37::AID-MC1011>3.0.CO;2-7  }}
*{{cite journal  | author=Furukawa M, Zhang Y, McCarville J, ''et al.'' |title=The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 8185-97 |year= 2000 |pmid= 11027288 |doi= }}
*{{cite journal  |vauthors=Swaroop M, Gosink M, Sun Y |title=SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes |journal=DNA Cell Biol. |volume=20 |issue= 7 |pages= 425–34 |year= 2001 |pmid= 11506706 |doi= 10.1089/104454901750361488 |url=https://deepblue.lib.umich.edu/bitstream/2027.42/63441/1/104454901750361488.pdf }}
*{{cite journal  | author=Duan H, Tsvetkov LM, Liu Y, ''et al.'' |title=Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation. |journal=Mol. Carcinog. |volume=30 |issue= 1 |pages= 37-46 |year= 2001 |pmid= 11255262 |doi=  }}
*{{cite journal  |vauthors=Ahn BH, Kim TH, Bae YS |title=Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins |journal=Mol. Cells |volume=12 |issue= 2 |pages= 158–63 |year= 2002 |pmid= 11710515 |doi=  }}
*{{cite journal  | author=Swaroop M, Gosink M, Sun Y |title=SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes. |journal=DNA Cell Biol. |volume=20 |issue= 7 |pages= 425-34 |year= 2001 |pmid= 11506706 |doi= 10.1089/104454901750361488 }}
*{{cite journal  |vauthors=Furukawa M, Ohta T, Xiong Y |title=Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15758–65 |year= 2002 |pmid= 11861641 |doi= 10.1074/jbc.M108565200 }}
*{{cite journal  | author=Ahn BH, Kim TH, Bae YS |title=Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins. |journal=Mol. Cells |volume=12 |issue= 2 |pages= 158-63 |year= 2002 |pmid= 11710515 |doi=  }}
*{{cite journal  |vauthors=Kim SY, Bae YS, Park JW |title=Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein |journal=Free Radic. Res. |volume=36 |issue= 1 |pages= 73–8 |year= 2002 |pmid= 11999705 |doi=10.1080/10715760210164 }}
*{{cite journal  | author=Furukawa M, Ohta T, Xiong Y |title=Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15758-65 |year= 2002 |pmid= 11861641 |doi= 10.1074/jbc.M108565200 }}
*{{cite journal  |vauthors=Kim YS, Ha KS, Kim YH, Bae YS |title=The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation |journal=J. Biochem. Mol. Biol. |volume=35 |issue= 6 |pages= 629–36 |year= 2003 |pmid= 12470599 |doi= 10.5483/bmbrep.2002.35.6.629}}
*{{cite journal | author=Kim SY, Bae YS, Park JW |title=Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein. |journal=Free Radic. Res. |volume=36 |issue= 1 |pages= 73-8 |year= 2002 |pmid= 11999705 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Kim YS, Ha KS, Kim YH, Bae YS |title=The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation. |journal=J. Biochem. Mol. Biol. |volume=35 |issue= 6 |pages= 629-36 |year= 2003 |pmid= 12470599 |doi=  }}
*{{cite journal   |vauthors=Kim SY, Lee JH, Yang ES, etal |title=Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 3 |pages= 671–4 |year= 2003 |pmid= 12565832 |doi=10.1016/S0006-291X(03)00018-4 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Kim YS, Lee JY, Son MY, etal |title=Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1 |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28462–9 |year= 2003 |pmid= 12748192 |doi= 10.1074/jbc.M302584200 }}
*{{cite journal | author=Kim SY, Lee JH, Yang ES, ''et al.'' |title=Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 3 |pages= 671-4 |year= 2003 |pmid= 12565832 |doi= }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Kim YS, Lee JY, Son MY, ''et al.'' |title=Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28462-9 |year= 2003 |pmid= 12748192 |doi= 10.1074/jbc.M302584200 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{Refend}}


== External links ==
== External links ==
* {{MeshName|RNF7+protein,+human}}
* {{MeshName|RNF7+protein,+human}}


{{protein-stub}}
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[[Category:RING finger proteins]]
 
 
{{Gene-3-stub}}

Latest revision as of 12:22, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.[1][2][3]

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Interactions

RNF7 has been shown to interact with CSNK2B.[4]

See also

References

  1. ↑ Duan H, Wang Y, Aviram M, Swaroop M, Loo JA, Bian J, Tian Y, Mueller T, Bisgaier CL, Sun Y (April 1999). "SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents". Mol Cell Biol. 19 (4): 3145–55. PMC 84108. PMID 10082581.
  2. ↑ Ohta T, Michel JJ, Schottelius AJ, Xiong Y (May 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol Cell. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. PMID 10230407.
  3. ↑ 3.0 3.1 "Entrez Gene: RNF7 ring finger protein 7".
  4. ↑ Ahn, B H; Kim T H; Bae Y S (October 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Mol. Cells. Korea (South). 12 (2): 158–63. ISSN 1016-8478. PMID 11710515.

Further reading

External links


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