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*{{cite journal |vauthors=Furukawa M, Zhang Y, McCarville J, etal |title=The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1 |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 8185–97 |year= 2000 |pmid= 11027288 |doi=10.1128/MCB.20.21.8185-8197.2000 | pmc=86428 }} | *{{cite journal |vauthors=Furukawa M, Zhang Y, McCarville J, etal |title=The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1 |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 8185–97 |year= 2000 |pmid= 11027288 |doi=10.1128/MCB.20.21.8185-8197.2000 | pmc=86428 }} | ||
*{{cite journal |vauthors=Duan H, Tsvetkov LM, Liu Y, etal |title=Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation |journal=Mol. Carcinog. |volume=30 |issue= 1 |pages= 37–46 |year= 2001 |pmid= 11255262 |doi=10.1002/1098-2744(200101)30:1<37::AID-MC1011>3.0.CO;2-7 }} | *{{cite journal |vauthors=Duan H, Tsvetkov LM, Liu Y, etal |title=Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation |journal=Mol. Carcinog. |volume=30 |issue= 1 |pages= 37–46 |year= 2001 |pmid= 11255262 |doi=10.1002/1098-2744(200101)30:1<37::AID-MC1011>3.0.CO;2-7 }} | ||
*{{cite journal |vauthors=Swaroop M, Gosink M, Sun Y |title=SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes |journal=DNA Cell Biol. |volume=20 |issue= 7 |pages= 425–34 |year= 2001 |pmid= 11506706 |doi= 10.1089/104454901750361488 }} | *{{cite journal |vauthors=Swaroop M, Gosink M, Sun Y |title=SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes |journal=DNA Cell Biol. |volume=20 |issue= 7 |pages= 425–34 |year= 2001 |pmid= 11506706 |doi= 10.1089/104454901750361488 |url=https://deepblue.lib.umich.edu/bitstream/2027.42/63441/1/104454901750361488.pdf }} | ||
*{{cite journal |vauthors=Ahn BH, Kim TH, Bae YS |title=Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins |journal=Mol. Cells |volume=12 |issue= 2 |pages= 158–63 |year= 2002 |pmid= 11710515 |doi= }} | *{{cite journal |vauthors=Ahn BH, Kim TH, Bae YS |title=Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins |journal=Mol. Cells |volume=12 |issue= 2 |pages= 158–63 |year= 2002 |pmid= 11710515 |doi= }} | ||
*{{cite journal |vauthors=Furukawa M, Ohta T, Xiong Y |title=Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15758–65 |year= 2002 |pmid= 11861641 |doi= 10.1074/jbc.M108565200 }} | *{{cite journal |vauthors=Furukawa M, Ohta T, Xiong Y |title=Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15758–65 |year= 2002 |pmid= 11861641 |doi= 10.1074/jbc.M108565200 }} | ||
*{{cite journal |vauthors=Kim SY, Bae YS, Park JW |title=Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein |journal=Free Radic. Res. |volume=36 |issue= 1 |pages= 73–8 |year= 2002 |pmid= 11999705 |doi=10.1080/10715760210164 }} | *{{cite journal |vauthors=Kim SY, Bae YS, Park JW |title=Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein |journal=Free Radic. Res. |volume=36 |issue= 1 |pages= 73–8 |year= 2002 |pmid= 11999705 |doi=10.1080/10715760210164 }} | ||
*{{cite journal |vauthors=Kim YS, Ha KS, Kim YH, Bae YS |title=The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation |journal=J. Biochem. Mol. Biol. |volume=35 |issue= 6 |pages= 629–36 |year= 2003 |pmid= 12470599 |doi= 10.5483/bmbrep.2002.35.6.629}} | *{{cite journal |vauthors=Kim YS, Ha KS, Kim YH, Bae YS |title=The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation |journal=J. Biochem. Mol. Biol. |volume=35 |issue= 6 |pages= 629–36 |year= 2003 |pmid= 12470599 |doi= 10.5483/bmbrep.2002.35.6.629}} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Kim SY, Lee JH, Yang ES, etal |title=Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 3 |pages= 671–4 |year= 2003 |pmid= 12565832 |doi=10.1016/S0006-291X(03)00018-4 }} | *{{cite journal |vauthors=Kim SY, Lee JH, Yang ES, etal |title=Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 3 |pages= 671–4 |year= 2003 |pmid= 12565832 |doi=10.1016/S0006-291X(03)00018-4 }} | ||
*{{cite journal |vauthors=Kim YS, Lee JY, Son MY, etal |title=Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1 |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28462–9 |year= 2003 |pmid= 12748192 |doi= 10.1074/jbc.M302584200 }} | *{{cite journal |vauthors=Kim YS, Lee JY, Son MY, etal |title=Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1 |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28462–9 |year= 2003 |pmid= 12748192 |doi= 10.1074/jbc.M302584200 }} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }} | ||
}} | }} | ||
{{Refend}} | {{Refend}} | ||
Latest revision as of 12:22, 4 November 2018
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RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.[1][2][3]
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]
Interactions
RNF7 has been shown to interact with CSNK2B.[4]
See also
References
- ↑ Duan H, Wang Y, Aviram M, Swaroop M, Loo JA, Bian J, Tian Y, Mueller T, Bisgaier CL, Sun Y (April 1999). "SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents". Mol Cell Biol. 19 (4): 3145–55. PMC 84108. PMID 10082581.
- ↑ Ohta T, Michel JJ, Schottelius AJ, Xiong Y (May 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol Cell. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. PMID 10230407.
- ↑ 3.0 3.1 "Entrez Gene: RNF7 ring finger protein 7".
- ↑ Ahn, B H; Kim T H; Bae Y S (October 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Mol. Cells. Korea (South). 12 (2): 158–63. ISSN 1016-8478. PMID 11710515.
Further reading
- Tan P, Fuchs SY, Chen A, et al. (1999). "Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha". Mol. Cell. 3 (4): 527–33. doi:10.1016/S1097-2765(00)80481-5. PMID 10230406.
- Swaroop M, Bian J, Aviram M, et al. (1999). "Expression, purification, and biochemical characterization of SAG, a ring finger redox-sensitive protein". Free Radic. Biol. Med. 27 (1–2): 193–202. doi:10.1016/S0891-5849(99)00078-7. PMID 10443936.
- Sun Y (1999). "Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection". Carcinogenesis. 20 (10): 1899–903. doi:10.1093/carcin/20.10.1899. PMID 10506102.
- Son MY, Park JW, Kim YS, et al. (1999). "Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif". Biochem. Biophys. Res. Commun. 263 (3): 743–8. doi:10.1006/bbrc.1999.1460. PMID 10512750.
- Chen A, Wu K, Fuchs SY, et al. (2000). "The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation". J. Biol. Chem. 275 (20): 15432–9. doi:10.1074/jbc.M907300199. PMID 10748083.
- Swaroop M, Wang Y, Miller P, et al. (2000). "Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation". Oncogene. 19 (24): 2855–66. doi:10.1038/sj.onc.1203635. PMID 10851089.
- Furukawa M, Zhang Y, McCarville J, et al. (2000). "The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1". Mol. Cell. Biol. 20 (21): 8185–97. doi:10.1128/MCB.20.21.8185-8197.2000. PMC 86428. PMID 11027288.
- Duan H, Tsvetkov LM, Liu Y, et al. (2001). "Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation". Mol. Carcinog. 30 (1): 37–46. doi:10.1002/1098-2744(200101)30:1<37::AID-MC1011>3.0.CO;2-7. PMID 11255262.
- Swaroop M, Gosink M, Sun Y (2001). "SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes" (PDF). DNA Cell Biol. 20 (7): 425–34. doi:10.1089/104454901750361488. PMID 11506706.
- Ahn BH, Kim TH, Bae YS (2002). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Mol. Cells. 12 (2): 158–63. PMID 11710515.
- Furukawa M, Ohta T, Xiong Y (2002). "Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins". J. Biol. Chem. 277 (18): 15758–65. doi:10.1074/jbc.M108565200. PMID 11861641.
- Kim SY, Bae YS, Park JW (2002). "Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein". Free Radic. Res. 36 (1): 73–8. doi:10.1080/10715760210164. PMID 11999705.
- Kim YS, Ha KS, Kim YH, Bae YS (2003). "The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation". J. Biochem. Mol. Biol. 35 (6): 629–36. doi:10.5483/bmbrep.2002.35.6.629. PMID 12470599.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kim SY, Lee JH, Yang ES, et al. (2003). "Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage". Biochem. Biophys. Res. Commun. 301 (3): 671–4. doi:10.1016/S0006-291X(03)00018-4. PMID 12565832.
- Kim YS, Lee JY, Son MY, et al. (2003). "Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1". J. Biol. Chem. 278 (31): 28462–9. doi:10.1074/jbc.M302584200. PMID 12748192.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
External links
- RNF7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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