Cell adhesion molecule 1: Difference between revisions

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{{Infobox_gene}}
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'''Cell adhesion molecule 1''' is a [[protein]] that, in humans, is encoded by the ''CADM1'' [[gene]].<ref name="pmid10610705">{{cite journal | vauthors = Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, Arai K, Aikawa Y, Tsuda H, Hirohashi S, Asakawa S, Shimizu N, Soeda E, Sakaki Y, Ohki M | title = A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2 | journal = Genomics | volume = 62 | issue = 2 | pages = 139–46 |date=Feb 2000 | pmid = 10610705 | pmc =  | doi = 10.1006/geno.1999.6001 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CADM1 cell adhesion molecule 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23705| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Cell adhesion molecule 1
| HGNCid = 5951
| Symbol = CADM1
| AltSymbols =; BL2; DKFZp686F1789; IGSF4; IGSF4A; MGC149785; MGC51880; NECL2; Necl-2; RA175; ST17; SYNCAM; TSLC1; sTSLC-1; synCAM1
| OMIM = 605686
| ECnumber = 
| Homologene = 8641
| MGIid = 1889272
| GeneAtlas_image1 = PBB_GE_CADM1_209030_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CADM1_209032_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}}
| Process = {{GNF_GO|id=GO:0001913 |text = T cell mediated cytotoxicity}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007157 |text = heterophilic cell adhesion}} {{GNF_GO|id=GO:0008037 |text = cell recognition}} {{GNF_GO|id=GO:0016338 |text = calcium-independent cell-cell adhesion}} {{GNF_GO|id=GO:0042271 |text = susceptibility to natural killer cell mediated cytotoxicity}} {{GNF_GO|id=GO:0050715 |text = positive regulation of cytokine secretion}} {{GNF_GO|id=GO:0050798 |text = activated T cell proliferation}} {{GNF_GO|id=GO:0051606 |text = detection of stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23705
    | Hs_Ensembl = ENSG00000182985
    | Hs_RefseqProtein = NP_055148
    | Hs_RefseqmRNA = NM_014333
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 114552404
    | Hs_GenLoc_end = 114880322
    | Hs_Uniprot = 
    | Mm_EntrezGene = 54725
    | Mm_Ensembl = ENSMUSG00000032076
    | Mm_RefseqmRNA = NM_001025600
    | Mm_RefseqProtein = NP_001020771
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 47281368
    | Mm_GenLoc_end = 47601384
    | Mm_Uniprot = 
  }}
}}
'''Cell adhesion molecule 1''', also known as '''CADM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CADM1 cell adhesion molecule 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23705| accessdate = }}</ref>
 
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==Model organisms==
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: right;" |
|+ ''Cadm1'' knockout mouse phenotype
|-
! Characteristic!! Phenotype
|-
| [[Homozygote]] viability || bgcolor="#488ED3"|Normal
|-
| Fertility || bgcolor="#C40000"|Abnormal
|-
| Body weight || bgcolor="#488ED3"|Normal
|-
| [[Open Field (animal test)|Anxiety]] || bgcolor="#488ED3"|Normal
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
|-
| Grip strength || bgcolor="#488ED3"|Normal
|-
| [[Hot plate test|Hot plate]] || bgcolor="#488ED3"|Normal
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
|-
| [[Rotarod]] || bgcolor="#488ED3"|Normal
|-
| Non-Invasive Blood Pressure || bgcolor="#488ED3"|Normal
|-
| [[Prepulse inhibition]] || bgcolor="#488ED3"|Normal
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
|-
| Body temperature || bgcolor="#488ED3"|Normal
|-
| Eye morphology || bgcolor="#488ED3"|Normal
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
|-
| [[Haematology]] || bgcolor="#488ED3"|Normal
|-
| [[Micronucleus test]] || bgcolor="#488ED3"|Normal
|-
| Heart weight || bgcolor="#488ED3"|Normal
|-
| Tail epidermis wholemount || bgcolor="#488ED3"|Normal
|-
| Brain histopathology || bgcolor="#488ED3"|Normal
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Salmonella'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAMQ/salmonella-challenge/ |title=''Salmonella'' infection data for Cadm1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| ''[[Citrobacter]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Citrobacter'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAMQ/citrobacter-challenge/ |title=''Citrobacter'' infection data for Cadm1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| colspan=2; style="text-align: center;" | All tests and analysis from<ref name="mgp_reference">{{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages =  925–7 }}</ref>
|}
[[Model organism]]s have been used in the study of CADM1 function. A conditional [[knockout mouse]] line, called ''Cadm1<sup>tm1.2Brd</sup>''<ref name="mgi_allele_ref">{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:3625158 |title=Mouse Genome Informatics}}</ref> was generated.<ref name=LvDW>{{Cite journal
| last1 = Van Der Weyden | first1 = L.
| last2 = Arends | first2 = M. J.
| last3 = Chausiaux | first3 = O. E.
| last4 = Ellis | first4 = P. J.
| last5 = Lange | first5 = U. C.
| last6 = Surani | first6 = M. A.
| last7 = Affara | first7 = N.
| last8 = Murakami | first8 = Y.
| last9 = Adams | first9 = D. J.
| doi = 10.1128/MCB.26.9.3595-3609.2006
| last10 = Bradley | first10 = A.
| title = Loss of TSLC1 Causes Male Infertility Due to a Defect at the Spermatid Stage of Spermatogenesis
| journal = Molecular and Cellular Biology
| volume = 26
| issue = 9
| pages = 3595–3609
| year = 2006
| pmid = 16611999
| pmc =1447413
}}</ref> Male and female animals underwent a standardized [[phenotypic screen]] to determine the effects of deletion.<ref name="mgp_reference" /><ref name="pmid21722353">{{cite journal| vauthors=van der Weyden L, White JK, Adams DJ, Logan DW| title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224  | pmc=3218837}}</ref> Twenty six tests were carried out on homozygous [[mutant]] mice and one significant abnormality was observed: males were infertile.<ref name="mgp_reference" /> Further analysis showed [[spermatogenesis]] had arrested in these mice.<ref name=LvDW/>
==Interactions==
Cell adhesion molecule 1 has been shown to [[Protein-protein interaction|interact]] with [[EPB41L3]].<ref name=pmid12234973>{{cite journal |last=Yageta |first=Mika |author2=Kuramochi Masami|author3=Masuda Mari|author4=Fukami Takeshi|author5=Fukuhara Hiroshi|author6=Maruyama Tomoko|author7=Shibuya Masabumi|author8=Murakami Yoshinori |date=Sep 2002 |title=Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer |journal=Cancer Res. |volume=62 |issue=18 |pages=5129–33 |publisher= |location = United States| issn = 0008-5472| pmid = 12234973 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
==See also==
* [[Cell adhesion molecule]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Watabe K, Ito A, Koma YI, Kitamura Y |title=IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function. |journal=Histol. Histopathol. |volume=18 |issue= 4 |pages= 1321-9 |year= 2004 |pmid= 12973698 |doi=  }}
*{{cite journal  | vauthors=Watabe K, Ito A, Koma YI, Kitamura Y |title=IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function. |journal=Histol. Histopathol. |volume=18 |issue= 4 |pages= 1321–9 |year= 2004 |pmid= 12973698 |doi=  }}
*{{cite journal  | author=Gomyo H, Arai Y, Tanigami A, ''et al.'' |title=A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2. |journal=Genomics |volume=62 |issue= 2 |pages= 139-46 |year= 2000 |pmid= 10610705 |doi= 10.1006/geno.1999.6001 }}
*{{cite journal  | author=Kuramochi M |title=TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer |journal=Nat. Genet. |volume=27 |issue= 4 |pages= 427–30 |year= 2001 |pmid= 11279526 |doi= 10.1038/86934  |name-list-format=vanc| author2=Fukuhara H | author3=Nobukuni T | display-authors=3  | last4=Kanbe  | first4=Takamasa  | last5=Maruyama  | first5=Tomoko  | last6=Ghosh  | first6=Hara P.  | last7=Pletcher | first7=Mathew  | last8=Isomura  | first8=Minoru  | last9=Onizuka  | first9=Masataka }}
*{{cite journal  | author=Kuramochi M, Fukuhara H, Nobukuni T, ''et al.'' |title=TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. |journal=Nat. Genet. |volume=27 |issue= 4 |pages= 427-30 |year= 2001 |pmid= 11279526 |doi= 10.1038/86934 }}
*{{cite journal  | author=Masuda M |title=The tumor suppressor protein TSLC1 is involved in cell-cell adhesion |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 31014–9 |year= 2002 |pmid= 12050160 |doi= 10.1074/jbc.M203620200  |name-list-format=vanc| author2=Yageta M  | author3=Fukuhara H | display-authors=3  | last4=Kuramochi | first4=M | last5=Maruyama  | first5=T  | last6=Nomoto  | first6=A  | last7=Murakami  | first7=Y }}
*{{cite journal | author=Masuda M, Yageta M, Fukuhara H, ''et al.'' |title=The tumor suppressor protein TSLC1 is involved in cell-cell adhesion. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 31014-9 |year= 2002 |pmid= 12050160 |doi= 10.1074/jbc.M203620200 }}
*{{cite journal  | author=Fukuhara H |title=Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer |journal=Jpn. J. Cancer Res. |volume=93 |issue= 6 |pages= 605–9 |year= 2003 |pmid= 12079507 |doi= 10.1111/j.1349-7006.2002.tb01297.x|name-list-format=vanc| author2=Kuramochi M | author3=Fukami T  | display-authors=3  | last4=Kasahara  | first4=K  | last5=Furuhata  | first5=M  | last6=Nobukuni  | first6=T  | last7=Maruyama  | first7=T  | last8=Isogai  | first8=K  | last9=Sekiya  | first9=T  }}
*{{cite journal | author=Fukuhara H, Kuramochi M, Fukami T, ''et al.'' |title=Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer. |journal=Jpn. J. Cancer Res. |volume=93 |issue= 6 |pages= 605-9 |year= 2003 |pmid= 12079507 |doi=  }}
*{{cite journal  | author=Allinen M |title=Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylation |journal=Genes Chromosomes Cancer |volume=34 |issue= 4 |pages= 384–9 |year= 2002 |pmid= 12112527 |doi= 10.1002/gcc.10079 |name-list-format=vanc| author2=Peri L  | author3=Kujala S  | display-authors=3  | last4=Lahti-Domenici  | first4=Jaana  | last5=Outila  | first5=Kati  | last6=Karppinen  | first6=Sanna-Maria  | last7=Launonen  | first7=Virpi  | last8=Winqvist | first8=Robert }}
*{{cite journal  | author=Allinen M, Peri L, Kujala S, ''et al.'' |title=Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylation. |journal=Genes Chromosomes Cancer |volume=34 |issue= 4 |pages= 384-9 |year= 2002 |pmid= 12112527 |doi= 10.1002/gcc.10079 }}
*{{cite journal  | author=Biederer T |title=SynCAM, a synaptic adhesion molecule that drives synapse assembly |journal=Science |volume=297 |issue= 5586 |pages= 1525–31 |year= 2002 |pmid= 12202822 |doi= 10.1126/science.1072356  |name-list-format=vanc| author2=Sara Y  | author3=Mozhayeva M  | display-authors=3  | last4=Atasoy  | first4=D  | last5=Liu | first5=X  | last6=Kavalali  | first6=ET  | last7=Südhof  | first7=TC |bibcode=2002Sci...297.1525B}}
*{{cite journal  | author=Biederer T, Sara Y, Mozhayeva M, ''et al.'' |title=SynCAM, a synaptic adhesion molecule that drives synapse assembly. |journal=Science |volume=297 |issue= 5586 |pages= 1525-31 |year= 2002 |pmid= 12202822 |doi= 10.1126/science.1072356 }}
*{{cite journal  | author=Yageta M |title=Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer |journal=Cancer Res. |volume=62 |issue= 18 |pages= 5129–33 |year= 2002 |pmid= 12234973 |doi=  |name-list-format=vanc| author2=Kuramochi M  | author3=Masuda M  | display-authors=3  | last4=Fukami  | first4=T  | last5=Fukuhara  | first5=H  | last6=Maruyama  | first6=T  | last7=Shibuya  | first7=M  | last8=Murakami  | first8=Y  }}
*{{cite journal  | author=Yageta M, Kuramochi M, Masuda M, ''et al.'' |title=Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. |journal=Cancer Res. |volume=62 |issue= 18 |pages= 5129-33 |year= 2002 |pmid= 12234973 |doi= }}
*{{cite journal  | author=Jansen M |title=Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs |journal=Cancer Biol. Ther. |volume=1 |issue= 3 |pages= 293–6 |year= 2003 |pmid= 12432281 |doi=  |name-list-format=vanc| author2=Fukushima N  | author3=Rosty C  | display-authors=3  | last4=Walter  | first4=K  | last5=Altink  | first5=R  | last6=Heek  | first6=TV  | last7=Hruban  | first7=R  | last8=Offerhaus  | first8=JG  | last9=Goggins  | first9=M  }}
*{{cite journal | author=Jansen M, Fukushima N, Rosty C, ''et al.'' |title=Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs. |journal=Cancer Biol. Ther. |volume=1 |issue= 3 |pages= 293-6 |year= 2003 |pmid= 12432281 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Honda T |title=Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines |journal=Jpn. J. Cancer Res. |volume=93 |issue= 8 |pages= 857–60 |year= 2003 |pmid= 12716461 |doi= 10.1111/j.1349-7006.2002.tb01329.x|name-list-format=vanc| author2=Tamura G  | author3=Waki T | display-authors=3  | last4=Jin  | first4=Z  | last5=Sato  | first5=K  | last6=Motoyama  | first6=T  | last7=Kawata  | first7=S  | last8=Kimura  | first8=W  | last9=Nishizuka  | first9=S }}
*{{cite journal | author=Honda T, Tamura G, Waki T, ''et al.'' |title=Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines. |journal=Jpn. J. Cancer Res. |volume=93 |issue= 8 |pages= 857-60 |year= 2003 |pmid= 12716461 |doi= }}
*{{cite journal  | author=Shingai T |title=Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35421–7 |year= 2003 |pmid= 12826663 |doi= 10.1074/jbc.M305387200  |name-list-format=vanc| author2=Ikeda W  | author3=Kakunaga S  | display-authors=3  | last4=Morimoto  | first4=K  | last5=Takekuni  | first5=K  | last6=Itoh  | first6=S  | last7=Satoh  | first7=K  | last8=Takeuchi  | first8=M  | last9=Imai  | first9=T }}
*{{cite journal | author=Shingai T, Ikeda W, Kakunaga S, ''et al.'' |title=Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35421-7 |year= 2003 |pmid= 12826663 |doi= 10.1074/jbc.M305387200 }}
*{{cite journal  | author=Ito A |title=Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma |journal=Lab. Invest. |volume=83 |issue= 8 |pages= 1175–83 |year= 2003 |pmid= 12920246 |doi=10.1097/01.LAB.0000081391.28136.80  |name-list-format=vanc| author2=Okada M  | author3=Uchino K  | display-authors=3  | last4=Wakayama  | first4=T  | last5=Koma  | first5=Y  | last6=Iseki  | first6=S  | last7=Tsubota  | first7=N  | last8=Okita  | first8=Y  | last9=Kitamura  | first9=Y  }}
*{{cite journal  | author=Ito A, Okada M, Uchino K, ''et al.'' |title=Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma. |journal=Lab. Invest. |volume=83 |issue= 8 |pages= 1175-83 |year= 2003 |pmid= 12920246 |doi= }}
*{{cite journal  | author=Fukami T |title=Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines |journal=Int. J. Cancer |volume=107 |issue= 1 |pages= 53–9 |year= 2003 |pmid= 12925956 |doi= 10.1002/ijc.11348  |name-list-format=vanc| author2=Fukuhara H  | author3=Kuramochi M  | display-authors=3  | last4=Maruyama  | first4=Tomoko  | last5=Isogai  | first5=Kana  | last6=Sakamoto  | first6=Michiie  | last7=Takamoto  | first7=Shinichi  | last8=Murakami  | first8=Yoshinori }}
*{{cite journal | author=Fukami T, Fukuhara H, Kuramochi M, ''et al.'' |title=Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. |journal=Int. J. Cancer |volume=107 |issue= 1 |pages= 53-9 |year= 2003 |pmid= 12925956 |doi= 10.1002/ijc.11348 }}
*{{cite journal  | author=Uchino K |title=Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung |journal=Cancer |volume=98 |issue= 5 |pages= 1002–7 |year= 2003 |pmid= 12942568 |doi= 10.1002/cncr.11599  |name-list-format=vanc| author2=Ito A  | author3=Wakayama T  | display-authors=3  | last4=Koma  | first4=Yu-Ichiro  | last5=Okada  | first5=Tomoyo  | last6=Ohbayashi  | first6=Chiho  | last7=Iseki  | first7=Shoichi  | last8=Kitamura  | first8=Yukihiko  | last9=Tsubota  | first9=Noriaki }}
*{{cite journal  | author=Uchino K, Ito A, Wakayama T, ''et al.'' |title=Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung. |journal=Cancer |volume=98 |issue= 5 |pages= 1002-7 |year= 2003 |pmid= 12942568 |doi= 10.1002/cncr.11599 }}
*{{cite journal  | author=Clark HF |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697  |name-list-format=vanc| author2=Gurney AL  | author3=Abaya E  | display-authors=3  | last4=Baker  | first4=K  | last5=Baldwin  | first5=D  | last6=Brush  | first6=J  | last7=Chen  | first7=J  | last8=Chow  | first8=B  | last9=Chui  | first9=C }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | author=Fukuhara H |title=Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg |journal=Oncogene |volume=22 |issue= 40 |pages= 6160–5 |year= 2003 |pmid= 13679854 |doi= 10.1038/sj.onc.1206744  |name-list-format=vanc| author2=Masuda M  | author3=Yageta M  | display-authors=3  | last4=Fukami  | first4=Takeshi  | last5=Kuramochi  | first5=Masami  | last6=Maruyama  | first6=Tomoko  | last7=Kitamura  | first7=Tadaichi  | last8=Murakami  | first8=Yoshinori }}
*{{cite journal | author=Fukuhara H, Masuda M, Yageta M, ''et al.'' |title=Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. |journal=Oncogene |volume=22 |issue= 40 |pages= 6160-5 |year= 2003 |pmid= 13679854 |doi= 10.1038/sj.onc.1206744 }}
*{{cite journal  | author=Ito T |title=Involvement of TSLC1 in progression of esophageal squamous cell carcinoma |journal=Cancer Res. |volume=63 |issue= 19 |pages= 6320–6 |year= 2003 |pmid= 14559819 |doi=  |name-list-format=vanc| author2=Shimada Y  | author3=Hashimoto Y  | display-authors=3  | last4=Kaganoi  | first4=J  | last5=Kan  | first5=T  | last6=Watanabe  | first6=G  | last7=Murakami  | first7=Y  | last8=Imamura  | first8=M  }}
*{{cite journal  | author=Ito T, Shimada Y, Hashimoto Y, ''et al.'' |title=Involvement of TSLC1 in progression of esophageal squamous cell carcinoma. |journal=Cancer Res. |volume=63 |issue= 19 |pages= 6320-6 |year= 2003 |pmid= 14559819 |doi=  }}
*{{cite journal  | author=Mao X |title=The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer |journal=Cancer Res. |volume=63 |issue= 22 |pages= 7979–85 |year= 2004 |pmid= 14633730 |doi=  |name-list-format=vanc| author2=Seidlitz E  | author3=Ghosh K  | display-authors=3  | last4=Murakami  | first4=Y  | last5=Ghosh  | first5=HP }}
*{{cite journal  | author=Mao X, Seidlitz E, Ghosh K, ''et al.'' |title=The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer. |journal=Cancer Res. |volume=63 |issue= 22 |pages= 7979-85 |year= 2004 |pmid= 14633730 |doi=  }}
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[[Category:Genes mutated in mice]]

Latest revision as of 04:03, 1 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene.[1][2]

Model organisms

Model organisms have been used in the study of CADM1 function. A conditional knockout mouse line, called Cadm1tm1.2Brd[6] was generated.[7] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][8] Twenty six tests were carried out on homozygous mutant mice and one significant abnormality was observed: males were infertile.[5] Further analysis showed spermatogenesis had arrested in these mice.[7]

Interactions

Cell adhesion molecule 1 has been shown to interact with EPB41L3.[9]

See also

References

  1. ↑ Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, Arai K, Aikawa Y, Tsuda H, Hirohashi S, Asakawa S, Shimizu N, Soeda E, Sakaki Y, Ohki M (Feb 2000). "A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2". Genomics. 62 (2): 139–46. doi:10.1006/geno.1999.6001. PMID 10610705.
  2. ↑ "Entrez Gene: CADM1 cell adhesion molecule 1".
  3. ↑ "Salmonella infection data for Cadm1". Wellcome Trust Sanger Institute.
  4. ↑ "Citrobacter infection data for Cadm1". Wellcome Trust Sanger Institute.
  5. ↑ 5.0 5.1 5.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  6. ↑ "Mouse Genome Informatics".
  7. ↑ 7.0 7.1 Van Der Weyden, L.; Arends, M. J.; Chausiaux, O. E.; Ellis, P. J.; Lange, U. C.; Surani, M. A.; Affara, N.; Murakami, Y.; Adams, D. J.; Bradley, A. (2006). "Loss of TSLC1 Causes Male Infertility Due to a Defect at the Spermatid Stage of Spermatogenesis". Molecular and Cellular Biology. 26 (9): 3595–3609. doi:10.1128/MCB.26.9.3595-3609.2006. PMC 1447413. PMID 16611999.
  8. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  9. ↑ Yageta, Mika; Kuramochi Masami; Masuda Mari; Fukami Takeshi; Fukuhara Hiroshi; Maruyama Tomoko; Shibuya Masabumi; Murakami Yoshinori (Sep 2002). "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer". Cancer Res. United States. 62 (18): 5129–33. ISSN 0008-5472. PMID 12234973.

Further reading

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