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{{Infobox_gene}}
'''Slit homolog 2 protein''' is a [[protein]] that in humans is encoded by the ''SLIT2'' [[gene]].<ref name="pmid9813312">{{cite journal |author1=Itoh A |author2=Miyabayashi T |author3=Ohno M |author4=Sakano S | title = Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system | journal = Brain Res Mol Brain Res | volume = 62 | issue = 2 | pages = 175–86 |date=February 1999 | pmid = 9813312 | pmc =  | doi =10.1016/S0169-328X(98)00224-1  }}</ref><ref name="pmid18269211">{{cite journal | author = Chedotal A | title = Slits and their receptors | journal = Adv Exp Med Biol | volume = 621 | issue =  | pages = 65–80 |date=February 2008 | pmid = 18269211 | pmc =  | doi = 10.1007/978-0-387-76715-4_5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLIT2 slit homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9353| accessdate = }}</ref>
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==Interactions==
SLIT2 has been shown to [[Protein-protein interaction|interact]] with [[Glypican 1]].<ref name=pmid11375980>{{cite journal |last=Ronca |first=F |authorlink= |author2=Andersen J S |author3=Paech V |author4=Margolis R U  |date=August 2001 |title=Characterization of Slit protein interactions with glypican-1 |journal=J. Biol. Chem. |volume=276 |issue=31 |pages=29141–7 |publisher= |location = United States| issn = 0021-9258| pmid = 11375980 |doi = 10.1074/jbc.M100240200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
==References==
{{Reflist}}
==Further reading==
{{Refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  |author1=Wong K |author2=Park HT |author3=Wu JY |author4=Rao Y |title=Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. |journal=Curr. Opin. Genet. Dev. |volume=12 |issue= 5 |pages= 583–91 |year= 2003 |pmid= 12200164 |doi=10.1016/S0959-437X(02)00343-X  }}
*{{cite journal  |author1=Zhao XC |author2=Zhang LM |author3=Li Q |author4=Tong DY |author5=Fan LC |author6=An P |author7=Wu XY |author8=Chen WM |author9=Zhao P |author10=Wang J. |title=Isoflurane post-conditioning protects primary cultures of cortical neurons against oxygen and glucose deprivation injury via upregulation of Slit2/Robo1. |journal=Brain Res. |volume=1537 |pages= 283–9 |year= 2013 |pmid= 23994690 |doi=10.1016/j.brainres.2013.08.036 |pmc=3820100}}
*{{cite journal  |vauthors=Wang KH, Brose K, Arnott D, etal |title=Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. |journal=Cell |volume=96 |issue= 6 |pages= 771–84 |year= 1999 |pmid= 10102266 |doi=10.1016/S0092-8674(00)80588-7  }}
*{{cite journal  |vauthors=Brose K, Bland KS, Wang KH, etal |title=Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. |journal=Cell |volume=96 |issue= 6 |pages= 795–806 |year= 1999 |pmid= 10102268 |doi=10.1016/S0092-8674(00)80590-5  }}
*{{cite journal  |vauthors=Li HS, Chen JH, Wu W, etal |title=Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. |journal=Cell |volume=96 |issue= 6 |pages= 807–18 |year= 1999 |pmid= 10102269 |doi=10.1016/S0092-8674(00)80591-7  }}
*{{cite journal  |vauthors=Nguyen Ba-Charvet KT, Brose K, Marillat V, etal |title=Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. |journal=Neuron |volume=22 |issue= 3 |pages= 463–73 |year= 1999 |pmid= 10197527 |doi=10.1016/S0896-6273(00)80702-3  }}
*{{cite journal  |vauthors=Holmes GP, Negus K, Burridge L, etal |title=Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. |journal=Mech. Dev. |volume=79 |issue= 1–2 |pages= 57–72 |year= 1999 |pmid= 10349621 |doi=10.1016/S0925-4773(98)00174-9  }}
*{{cite journal  |vauthors=Liang Y, Annan RS, Carr SA, etal |title=Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17885–92 |year= 1999 |pmid= 10364234 |doi=10.1074/jbc.274.25.17885  }}
*{{cite journal  |vauthors=Wu W, Wong K, Chen J, etal |title=Directional guidance of neuronal migration in the olfactory system by the protein Slit. |journal=Nature |volume=400 |issue= 6742 |pages= 331–6 |year= 1999 |pmid= 10432110 |doi= 10.1038/22477  | pmc=2041931 |bibcode=1999Natur.400..331W }}
*{{cite journal  |vauthors=Georgas K, Burridge L, Smith K, etal |title=Assignment of the human slit homologue SLIT2 to human chromosome band 4p15.2. |journal=Cytogenet. Cell Genet. |volume=86 |issue= 3–4 |pages= 246–7 |year= 2000 |pmid= 10575218 |doi=10.1159/000015351  }}
*{{cite journal  |author1=Niclou SP |author2=Jia L |author3=Raper JA |title=Slit2 is a repellent for retinal ganglion cell axons. |journal=J. Neurosci. |volume=20 |issue= 13 |pages= 4962–74 |year= 2000 |pmid= 10864954 |doi=  }}
*{{cite journal  |author1=Zou Y |author2=Stoeckli E |author3=Chen H |author4=Tessier-Lavigne M |title=Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. |journal=Cell |volume=102 |issue= 3 |pages= 363–75 |year= 2000 |pmid= 10975526 |doi=10.1016/S0092-8674(00)00041-6  }}
*{{cite journal  |vauthors=Chen  JH, Wen L, Dupuis S, etal |title=The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons. |journal=J. Neurosci. |volume=21 |issue= 5 |pages= 1548–56 |year= 2001 |pmid= 11222645 |doi=  }}
*{{cite journal  |author1=Stein E |author2=Tessier-Lavigne M |title=Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. |journal=Science |volume=291 |issue= 5510 |pages= 1928–38 |year= 2001 |pmid= 11239147 |doi= 10.1126/science.1058445 |bibcode=2001Sci...291.1928S }}
*{{cite journal  |vauthors=Wu JY, Feng L, Park HT, etal |title=The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. |journal=Nature |volume=410 |issue= 6831 |pages= 948–52 |year= 2001 |pmid= 11309622 |doi= 10.1038/35073616  | pmc=2072862 }}
*{{cite journal  |author1=Ronca F |author2=Andersen JS |author3=Paech V |author4=Margolis RU |title=Characterization of Slit protein interactions with glypican-1. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29141–7 |year= 2001 |pmid= 11375980 |doi= 10.1074/jbc.M100240200 }}
*{{cite journal  |vauthors=Nguyen Ba-Charvet KT, Brose K, Ma L, etal |title=Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. |journal=J. Neurosci. |volume=21 |issue= 12 |pages= 4281–9 |year= 2001 |pmid= 11404413 |doi=  }}
*{{cite journal  |vauthors=Little M, Rumballe B, Georgas K, etal |title=Conserved modularity and potential for alternate splicing in mouse and human Slit genes. |journal=Int. J. Dev. Biol. |volume=46 |issue= 4 |pages= 385–91 |year= 2003 |pmid= 12141424 |doi=  }}
*{{cite journal  |vauthors=Dallol A, Da Silva NF, Viacava P, etal |title=SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. |journal=Cancer Res. |volume=62 |issue= 20 |pages= 5874–80 |year= 2002 |pmid= 12384551 |doi=  }}
}}
{{Refend}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Category:Slit proteins]]
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Slit homolog 2 (Drosophila)
| HGNCid = 11086
| Symbol = SLIT2
| AltSymbols =; FLJ14420; SLIL3; Slit-2
| OMIM = 603746
| ECnumber = 
| Homologene = 3516
| MGIid = 1315205
| GeneAtlas_image1 = PBB_GE_SLIT2_209897_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004963 |text = follicle-stimulating hormone receptor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001657 |text = ureteric bud development}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007509 |text = mesoderm migration}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0008038 |text = neuron recognition}} {{GNF_GO|id=GO:0008045 |text = motor axon guidance}} {{GNF_GO|id=GO:0008347 |text = glial cell migration}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0050772 |text = positive regulation of axonogenesis}} {{GNF_GO|id=GO:0050929 |text = induction of negative chemotaxis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9353
    | Hs_Ensembl = ENSG00000145147
    | Hs_RefseqProtein = NP_004778
    | Hs_RefseqmRNA = NM_004787
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 19863981
    | Hs_GenLoc_end = 20229900
    | Hs_Uniprot = O94813
    | Mm_EntrezGene = 20563
    | Mm_Ensembl = ENSMUSG00000031558
    | Mm_RefseqmRNA = NM_178804
    | Mm_RefseqProtein = NP_848919
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 48273041
    | Mm_GenLoc_end = 48593759
    | Mm_Uniprot = Q5DTL5
  }}
}}
'''Slit homolog 2 (Drosophila)''', also known as '''SLIT2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLIT2 slit homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9353| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Wong K, Park HT, Wu JY, Rao Y |title=Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. |journal=Curr. Opin. Genet. Dev. |volume=12 |issue= 5 |pages= 583-91 |year= 2003 |pmid= 12200164 |doi=  }}
*{{cite journal  | author=Itoh A, Miyabayashi T, Ohno M, Sakano S |title=Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. |journal=Brain Res. Mol. Brain Res. |volume=62 |issue= 2 |pages= 175-86 |year= 1999 |pmid= 9813312 |doi=  }}
*{{cite journal  | author=Wang KH, Brose K, Arnott D, ''et al.'' |title=Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. |journal=Cell |volume=96 |issue= 6 |pages= 771-84 |year= 1999 |pmid= 10102266 |doi=  }}
*{{cite journal  | author=Brose K, Bland KS, Wang KH, ''et al.'' |title=Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. |journal=Cell |volume=96 |issue= 6 |pages= 795-806 |year= 1999 |pmid= 10102268 |doi=  }}
*{{cite journal  | author=Li HS, Chen JH, Wu W, ''et al.'' |title=Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. |journal=Cell |volume=96 |issue= 6 |pages= 807-18 |year= 1999 |pmid= 10102269 |doi=  }}
*{{cite journal  | author=Nguyen Ba-Charvet KT, Brose K, Marillat V, ''et al.'' |title=Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. |journal=Neuron |volume=22 |issue= 3 |pages= 463-73 |year= 1999 |pmid= 10197527 |doi=  }}
*{{cite journal  | author=Holmes GP, Negus K, Burridge L, ''et al.'' |title=Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. |journal=Mech. Dev. |volume=79 |issue= 1-2 |pages= 57-72 |year= 1999 |pmid= 10349621 |doi=  }}
*{{cite journal  | author=Liang Y, Annan RS, Carr SA, ''et al.'' |title=Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17885-92 |year= 1999 |pmid= 10364234 |doi=  }}
*{{cite journal  | author=Wu W, Wong K, Chen J, ''et al.'' |title=Directional guidance of neuronal migration in the olfactory system by the protein Slit. |journal=Nature |volume=400 |issue= 6742 |pages= 331-6 |year= 1999 |pmid= 10432110 |doi= 10.1038/22477 }}
*{{cite journal  | author=Georgas K, Burridge L, Smith K, ''et al.'' |title=Assignment of the human slit homologue SLIT2 to human chromosome band 4p15.2. |journal=Cytogenet. Cell Genet. |volume=86 |issue= 3-4 |pages= 246-7 |year= 2000 |pmid= 10575218 |doi=  }}
*{{cite journal  | author=Niclou SP, Jia L, Raper JA |title=Slit2 is a repellent for retinal ganglion cell axons. |journal=J. Neurosci. |volume=20 |issue= 13 |pages= 4962-74 |year= 2000 |pmid= 10864954 |doi=  }}
*{{cite journal  | author=Zou Y, Stoeckli E, Chen H, Tessier-Lavigne M |title=Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. |journal=Cell |volume=102 |issue= 3 |pages= 363-75 |year= 2000 |pmid= 10975526 |doi=  }}
*{{cite journal  | author=Chen  JH, Wen L, Dupuis S, ''et al.'' |title=The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons. |journal=J. Neurosci. |volume=21 |issue= 5 |pages= 1548-56 |year= 2001 |pmid= 11222645 |doi=  }}
*{{cite journal  | author=Stein E, Tessier-Lavigne M |title=Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. |journal=Science |volume=291 |issue= 5510 |pages= 1928-38 |year= 2001 |pmid= 11239147 |doi= 10.1126/science.1058445 }}
*{{cite journal  | author=Wu JY, Feng L, Park HT, ''et al.'' |title=The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. |journal=Nature |volume=410 |issue= 6831 |pages= 948-52 |year= 2001 |pmid= 11309622 |doi= 10.1038/35073616 }}
*{{cite journal  | author=Ronca F, Andersen JS, Paech V, Margolis RU |title=Characterization of Slit protein interactions with glypican-1. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29141-7 |year= 2001 |pmid= 11375980 |doi= 10.1074/jbc.M100240200 }}
*{{cite journal  | author=Nguyen Ba-Charvet KT, Brose K, Ma L, ''et al.'' |title=Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. |journal=J. Neurosci. |volume=21 |issue= 12 |pages= 4281-9 |year= 2001 |pmid= 11404413 |doi=  }}
*{{cite journal  | author=Little M, Rumballe B, Georgas K, ''et al.'' |title=Conserved modularity and potential for alternate splicing in mouse and human Slit genes. |journal=Int. J. Dev. Biol. |volume=46 |issue= 4 |pages= 385-91 |year= 2003 |pmid= 12141424 |doi=  }}
*{{cite journal  | author=Dallol A, Da Silva NF, Viacava P, ''et al.'' |title=SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. |journal=Cancer Res. |volume=62 |issue= 20 |pages= 5874-80 |year= 2002 |pmid= 12384551 |doi=  }}
}}
{{refend}}


{{protein-stub}}
{{Gene-4-stub}}
{{WikiDoc Sources}}

Latest revision as of 12:01, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Slit homolog 2 protein is a protein that in humans is encoded by the SLIT2 gene.[1][2][3]


Interactions

SLIT2 has been shown to interact with Glypican 1.[4]

References

  1. ↑ Itoh A; Miyabayashi T; Ohno M; Sakano S (February 1999). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Res Mol Brain Res. 62 (2): 175–86. doi:10.1016/S0169-328X(98)00224-1. PMID 9813312.
  2. ↑ Chedotal A (February 2008). "Slits and their receptors". Adv Exp Med Biol. 621: 65–80. doi:10.1007/978-0-387-76715-4_5. PMID 18269211.
  3. ↑ "Entrez Gene: SLIT2 slit homolog 2 (Drosophila)".
  4. ↑ Ronca, F; Andersen J S; Paech V; Margolis R U (August 2001). "Characterization of Slit protein interactions with glypican-1". J. Biol. Chem. United States. 276 (31): 29141–7. doi:10.1074/jbc.M100240200. ISSN 0021-9258. PMID 11375980.

Further reading


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