TAF1C: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''TATA box-binding protein-associated factor RNA polymerase I subunit C''' is an [[enzyme]] that in humans is encoded by the ''TAF1C'' [[gene]].<ref name="pmid7801123">{{cite journal | vauthors = Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R | title = Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits | journal = Science | volume = 266 | issue = 5193 | pages = 1966–72 | year = 1994 | date = January 1995 | pmid = 7801123 | pmc =  | doi = 10.1126/science.7801123 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9013| accessdate = }}</ref>
'''TATA box-binding protein-associated factor RNA polymerase I subunit C''' is an [[enzyme]] that in humans is encoded by the ''TAF1C'' [[gene]].<ref name="pmid7801123">{{cite journal | vauthors = Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R | title = Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits | journal = Science | volume = 266 | issue = 5193 | pages = 1966–72 | year = 1994 | pmid = 7801123 | pmc =  | doi = 10.1126/science.7801123 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9013| accessdate = }}</ref>


== Function ==
== Function ==
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{{Refbegin | 2}}
{{Refbegin | 2}}
* {{cite journal | vauthors = Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M | title = Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1 | journal = Cytogenet. Cell Genet. | volume = 89 | issue = 1-2 | pages = 133–6 | year = 2000 | pmid = 10894955 | doi = 10.1159/000015592 }}
* {{cite journal | vauthors = Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M | title = Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1 | journal = Cytogenet. Cell Genet. | volume = 89 | issue = 1-2 | pages = 133–6 | year = 2000 | pmid = 10894955 | doi = 10.1159/000015592 }}
* {{cite journal | vauthors = Zhai W, Comai L | title = Repression of RNA polymerase I transcription by the tumor suppressor p53 | journal = Mol. Cell. Biol. | volume = 20 | issue = 16 | pages = 5930–8 | year = 2000 | pmid = 10913176 | pmc = 86070 | doi = 10.1128/MCB.20.16.5930-5938.2000 }}
* {{cite journal | vauthors = Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC | title = hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1373–82 | year = 2001 | pmid = 11250903 | pmc = 145519 | doi = 10.1093/emboj/20.6.1373 }}
* {{cite journal | vauthors = Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC | title = hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1373–82 | year = 2001 | pmid = 11250903 | pmc = 145519 | doi = 10.1093/emboj/20.6.1373 }}
* {{cite journal | vauthors = Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I | title = Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter | journal = EMBO Rep. | volume = 3 | issue = 11 | pages = 1082–7 | year = 2002 | pmid = 12393749 | pmc = 1307603 | doi = 10.1093/embo-reports/kvf212 }}
* {{cite journal | vauthors = Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I | title = Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter | journal = EMBO Rep. | volume = 3 | issue = 11 | pages = 1082–7 | year = 2002 | pmid = 12393749 | pmc = 1307603 | doi = 10.1093/embo-reports/kvf212 }}

Latest revision as of 09:20, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.[1][2]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[2]

Interactions

TAF1C has been shown to interact with UBTF.[3][4]

References

  1. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123.
  2. 2.0 2.1 "Entrez Gene: TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa".
  3. Voit R, Grummt I (November 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. doi:10.1073/pnas.231071698. PMC 61092. PMID 11698641.
  4. Zhai W, Comai L (August 2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176.

Further reading