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| {{mergeto|Cytochrome c oxidase subunit II|date=December 2007}}
| | #REDIRECT [[Cytochrome c oxidase subunit II]] |
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| | update_page = yes
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| | update_protein_box = yes
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| | update_summary = yes
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| {{GNF_Protein_box
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| | image =
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| | image_source =
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| | PDB =
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| | Name = Cytochrome c oxidase subunit II
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| | HGNCid = 7421
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| | Symbol = COX2
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| | AltSymbols =; MTCO2
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| | OMIM =
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| | ECnumber =
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| | Homologene = 5017
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| | MGIid = 102503
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| | Function = {{GNF_GO|id=GO:0004129 |text = cytochrome-c oxidase activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
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| | Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005746 |text = mitochondrial respiratory chain}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
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| | Process = {{GNF_GO|id=GO:0006123 |text = mitochondrial electron transport, cytochrome c to oxygen}} {{GNF_GO|id=GO:0006810 |text = transport}}
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| | Orthologs = {{GNF_Ortholog_box
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| | Hs_EntrezGene = 4513
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| | Hs_Ensembl = ENSG00000198712
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| | Hs_RefseqProtein = NP_536846
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| | Hs_RefseqmRNA =
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| | Hs_GenLoc_db =
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| | Hs_GenLoc_chr = MT
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| | Hs_GenLoc_start = 7587
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| | Hs_GenLoc_end = 8270
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| | Hs_Uniprot = P00403
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| | Mm_EntrezGene = 17709
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| | Mm_Ensembl = ENSMUSG00000064354
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| | Mm_RefseqmRNA =
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| | Mm_RefseqProtein = NP_904331
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| | Mm_GenLoc_db =
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| | Mm_GenLoc_chr = MT
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| | Mm_GenLoc_start = 7013
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| | Mm_GenLoc_end = 7696
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| | Mm_Uniprot = Q7JCZ1
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| }}
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| }}
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| '''Cytochrome c oxidase subunit II''', also known as '''COX2''', is a human protein and [[gene]].<ref>{{cite web | title = Entrez Gene: COX2 cytochrome c oxidase subunit II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4513| accessdate = }}</ref> that belongs to [[cytochrome c oxidase subunit II]] [[protein family]].
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| {{PBB_Summary
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| | section_title =
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| | summary_text =
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| ==References==
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| {{reflist|2}}
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| ==Further reading==
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| {{refbegin | 2}}
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| {{PBB_Further_reading
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| | citations =
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| *{{cite journal | author=Torroni A, Achilli A, Macaulay V, ''et al.'' |title=Harvesting the fruit of the human mtDNA tree. |journal=Trends Genet. |volume=22 |issue= 6 |pages= 339-45 |year= 2006 |pmid= 16678300 |doi= 10.1016/j.tig.2006.04.001 }}
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| *{{cite journal | author=Barrell BG, Bankier AT, Drouin J |title=A different genetic code in human mitochondria. |journal=Nature |volume=282 |issue= 5735 |pages= 189-94 |year= 1979 |pmid= 226894 |doi= }}
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| *{{cite journal | author=Bodenteich A, Mitchell LG, Polymeropoulos MH, Merril CR |title=Dinucleotide repeat in the human mitochondrial D-loop. |journal=Hum. Mol. Genet. |volume=1 |issue= 2 |pages= 140 |year= 1993 |pmid= 1301157 |doi= }}
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| *{{cite journal | author=Lu X, Walker T, MacManus JP, Seligy VL |title=Differentiation of HT-29 human colonic adenocarcinoma cells correlates with increased expression of mitochondrial RNA: effects of trehalose on cell growth and maturation. |journal=Cancer Res. |volume=52 |issue= 13 |pages= 3718-25 |year= 1992 |pmid= 1377597 |doi= }}
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| *{{cite journal | author=Marzuki S, Noer AS, Lertrit P, ''et al.'' |title=Normal variants of human mitochondrial DNA and translation products: the building of a reference data base. |journal=Hum. Genet. |volume=88 |issue= 2 |pages= 139-45 |year= 1992 |pmid= 1757091 |doi= }}
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| *{{cite journal | author=Moraes CT, Andreetta F, Bonilla E, ''et al.'' |title=Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region. |journal=Mol. Cell. Biol. |volume=11 |issue= 3 |pages= 1631-7 |year= 1991 |pmid= 1996112 |doi= }}
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| *{{cite journal | author=Power MD, Kiefer MC, Barr PJ, Reeves R |title=Nucleotide sequence of human mitochondrial cytochrome c oxidase II cDNA. |journal=Nucleic Acids Res. |volume=17 |issue= 16 |pages= 6734 |year= 1989 |pmid= 2550900 |doi= }}
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| *{{cite journal | author=Attardi G, Chomyn A, Doolittle RF, ''et al.'' |title=Seven unidentified reading frames of human mitochondrial DNA encode subunits of the respiratory chain NADH dehydrogenase. |journal=Cold Spring Harb. Symp. Quant. Biol. |volume=51 Pt 1 |issue= |pages= 103-14 |year= 1987 |pmid= 3472707 |doi= }}
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| *{{cite journal | author=Chomyn A, Cleeter MW, Ragan CI, ''et al.'' |title=URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit. |journal=Science |volume=234 |issue= 4776 |pages= 614-8 |year= 1986 |pmid= 3764430 |doi= }}
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| *{{cite journal | author=Chomyn A, Mariottini P, Cleeter MW, ''et al.'' |title=Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase. |journal=Nature |volume=314 |issue= 6012 |pages= 592-7 |year= 1985 |pmid= 3921850 |doi= }}
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| *{{cite journal | author=Anderson S, Bankier AT, Barrell BG, ''et al.'' |title=Sequence and organization of the human mitochondrial genome. |journal=Nature |volume=290 |issue= 5806 |pages= 457-65 |year= 1981 |pmid= 7219534 |doi= }}
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| *{{cite journal | author=Montoya J, Ojala D, Attardi G |title=Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs. |journal=Nature |volume=290 |issue= 5806 |pages= 465-70 |year= 1981 |pmid= 7219535 |doi= }}
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| *{{cite journal | author=Horai S, Hayasaka K, Kondo R, ''et al.'' |title=Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 2 |pages= 532-6 |year= 1995 |pmid= 7530363 |doi= }}
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| *{{cite journal | author=Ruvolo M, Zehr S, von Dornum M, ''et al.'' |title=Mitochondrial COII sequences and modern human origins. |journal=Mol. Biol. Evol. |volume=10 |issue= 6 |pages= 1115-35 |year= 1994 |pmid= 8277847 |doi= }}
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| *{{cite journal | author=Polyak K, Li Y, Zhu H, ''et al.'' |title=Somatic mutations of the mitochondrial genome in human colorectal tumours. |journal=Nat. Genet. |volume=20 |issue= 3 |pages= 291-3 |year= 1998 |pmid= 9806551 |doi= 10.1038/3108 }}
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| *{{cite journal | author=Kato MV |title=The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondria. |journal=Leuk. Lymphoma |volume=33 |issue= 1-2 |pages= 181-6 |year= 1999 |pmid= 10194136 |doi= }}
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| *{{cite journal | author=Andrews RM, Kubacka I, Chinnery PF, ''et al.'' |title=Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. |journal=Nat. Genet. |volume=23 |issue= 2 |pages= 147 |year= 1999 |pmid= 10508508 |doi= 10.1038/13779 }}
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| *{{cite journal | author=Ingman M, Kaessmann H, Pääbo S, Gyllensten U |title=Mitochondrial genome variation and the origin of modern humans. |journal=Nature |volume=408 |issue= 6813 |pages= 708-13 |year= 2001 |pmid= 11130070 |doi= 10.1038/35047064 }}
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| *{{cite journal | author=Finnilä S, Lehtonen MS, Majamaa K |title=Phylogenetic network for European mtDNA. |journal=Am. J. Hum. Genet. |volume=68 |issue= 6 |pages= 1475-84 |year= 2001 |pmid= 11349229 |doi= }}
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| *{{cite journal | author=Maca-Meyer N, González AM, Larruga JM, ''et al.'' |title=Major genomic mitochondrial lineages delineate early human expansions. |journal=BMC Genet. |volume=2 |issue= |pages= 13 |year= 2003 |pmid= 11553319 |doi= }}
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| }}
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| {{refend}}
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