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==Overview==
==Overview==
The [[hereditary spherocytosis]] was first described in 1871 by Vanlair and Masius, where they described [[Chronic (medical)|chronically]] [[Jaundice|icteric]] [[Patient|patients]] who had no [[bile]] in the [[urine]], no evidence of [[Hepato-biliary diseases|liver disease]] and often [[splenomegaly]] and [[family history]] of [[jaundice]]. It is the commonest [[Causality|cause]] of [[inherited]] [[Chronic (medical)|chronic]] [[hemolysis]] in the northern europe and north america.


==Historical Perspective==
==Historical Perspective==
* Perhaps the first case of haemolytic anaemia in the medical literature was described by the physician Claudius Galen (Dreyfus, 1942). The patient, a slave of the emperor Marcus Aurelius, hunted snakes. He was bitten by a viper and, in spite of treatment with the ‘usual drugs’, his skin ‘turned the colour of a ripe leek.’ Galen prescribed theriaca, which cured the patient. Galen explained, ‘The spleen produces colours of this type, darker even than those produced by the liver. They are difficult to explain, but easy to recognize if you have seen them often.’
* [[Hereditary spherocytosis]] was first described in 1871 by Vanlair and Masius, where they described [[Chronic (medical)|chronically]] [[Jaundice|icteric]] [[Patient|patients]] who had no [[bile]] in the [[urine]], no evidence of [[Hepato-biliary diseases|liver disease]] and often [[splenomegaly]] and [[family history]] of [[jaundice]].<ref>{{Cite journal
 
| author = [[Sayeeda Huq]], [[Mark A. C. Pietroni]], [[Hafizur Rahman]] & [[Mohammad Tariqul Alam]]
* The first recognizable reports of haemolytic anaemia were undoubtedly cases of paroxysmal cold haemoglobinuria because of the dramatic presentation. Johannis Actuarius, a court physician at Constantinople during the late thirteenth century described azure, livid and black urine following chilling of certain individuals (Major, 1945). The syndrome was well known by physicians of the mid‐nineteenth century. A relationship to jaundice was recognized and the absence of RBCs from the dark urine was noted. These patients were thought to suffer from a disorder of the kidneys.
| title = Hereditary spherocytosis
| journal = [[Journal of health, population, and nutrition]]
| volume = 28
| issue = 1
| pages = 107–109
| year = 2010
| month = February
| pmid = 20214092
}}</ref>
* It is the commonest [[Causality|cause]] of [[inherited]] [[Chronic (medical)|chronic]] [[hemolysis]] in the northern europe and north america.<ref>{{Cite journal
| author = [[Sayeeda Huq]], [[Mark A. C. Pietroni]], [[Hafizur Rahman]] & [[Mohammad Tariqul Alam]]
| title = Hereditary spherocytosis
| journal = [[Journal of health, population, and nutrition]]
| volume = 28
| issue = 1
| pages = 107–109
| year = 2010
| month = February
| pmid = 20214092
}}</ref>
* With remarkable discernment, Vanlair and Masius stated, ‘The [[jaundice]] of our [[patient]] appears to be a peculiar type of [[icterus]]. The fact that the patient’s mother and sister had a slight [[jaundice]] and that the sister had an [[enlarged spleen]] may indicate that this condition is one [[disease]] entity.'.<ref name="Packman2001">{{cite journal|last1=Packman|first1=Charles H.|title=The spherocytic Haemolytic Anaemias|journal=British Journal of Haematology|volume=112|issue=4|year=2001|pages=888–899|issn=0007-1048|doi=10.1046/j.1365-2141.2001.02440.x}}</ref>


==References==
==References==

Latest revision as of 20:16, 2 December 2018

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Overview

The hereditary spherocytosis was first described in 1871 by Vanlair and Masius, where they described chronically icteric patients who had no bile in the urine, no evidence of liver disease and often splenomegaly and family history of jaundice. It is the commonest cause of inherited chronic hemolysis in the northern europe and north america.

Historical Perspective

References

  1. Sayeeda Huq, Mark A. C. Pietroni, Hafizur Rahman & Mohammad Tariqul Alam (2010). "Hereditary spherocytosis". Journal of health, population, and nutrition. 28 (1): 107–109. PMID 20214092. Unknown parameter |month= ignored (help)
  2. Sayeeda Huq, Mark A. C. Pietroni, Hafizur Rahman & Mohammad Tariqul Alam (2010). "Hereditary spherocytosis". Journal of health, population, and nutrition. 28 (1): 107–109. PMID 20214092. Unknown parameter |month= ignored (help)
  3. Packman, Charles H. (2001). "The spherocytic Haemolytic Anaemias". British Journal of Haematology. 112 (4): 888–899. doi:10.1046/j.1365-2141.2001.02440.x. ISSN 0007-1048.

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