Endometrial cancer classification: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(7 intermediate revisions by 2 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Endometrial cancer}}
{{Endometrial cancer}}
{{CMG}}{{AE}}{{MD}}
{{CMG}}{{AE}}{{RAK}}


==Overview==
==Overview==
Endometrial cancer may be classified according to histology into 7 subtypes: endometrioid, uterine papillary [[serous]], mucinous,  clear cell, [[squamous cell]], mixed and undifferentiated.
Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.


==Classification==
==Classification==
===Classification Based on Pathogenesis===
Endometrial cancer may be classified according to histology into 2 types:<ref name="pmid6822361">{{cite journal| author=Bokhman JV| title=Two pathogenetic types of endometrial carcinoma. | journal=Gynecol Oncol | year= 1983 | volume= 15 | issue= 1 | pages= 10-7 | pmid=6822361 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6822361  }} </ref>
* Endometrial cancers are classified into either type 1 or type 2:<ref>{{Cite web | title = endometrial cancer classification | url =http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_9 }}</ref>
{| class="wikitable"
:* Type 1 may arise from complex atypical [[hyperplasia]] and is pathogenetically linked to unopposed estrogenic stimulation.
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Type
:* Type 2 develops from atrophic [[endometrium]] and is not linked to hormonally driven pathogenesis.
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Histology
===Classification Based on Histopathological Subtype===
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Prognosis
There are 7 subtypes of endometrial cancer based on histopathology:
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Pathogenesis
: 1. Endometrioid (75%–80%)(The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant [[glandular]] epithelial elements)
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Prevalence
::* Ciliated adenocarcinoma
|-
::* Secretory adenocarcinoma
| style="background:#DCDCDC;" align="center" + |Type I
::* [[Papillary]] or villoglandular
| style="background:#F5F5F5;" align="center" + |Endometroid (adenocarcinoma)
::* Adenocarcinoma with squamous differentiation
| style="background:#F5F5F5;" align="center" + |Favorable (estrogen-responsive)
:::* Adenoacanthoma
| style="background:#F5F5F5;" align="left" + |• May arise from atypical hyperplasia <br> • Linked to unopposed estrogen stimulation
:::* Adenosquamous (Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium)
| style="background:#F5F5F5;" align="center" + |80%  
: 2. Uterine papillary serous (<10%)
|-
: 3. Mucinous (1%)
| style="background:#DCDCDC;" align="center" + |Type II
: 4. Clear cell (4%)
| style="background:#F5F5F5;" align="left" + |• Endometroid <br>• Serous <br>• Clear cell <br>• Mucinous <br>• Squamous <br>• Mesonephric <br>• Undifferentiated
: 5. [[Squamous cell]] (<1%)
| style="background:#F5F5F5;" align="center" + |Typically bad prognosis
: 6. Mixed (10%)
| style="background:#F5F5F5;" align="left" + |• Develops from atrophic endometrium <br>• Not linked to hormonally driven pathogenesis
: 7. Undifferentiated
| style="background:#F5F5F5;" align="center" + |15-20%
|}


==References==
==References==
Line 36: Line 37:
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Gynecology]]
[[Category:Surgery]]

Latest revision as of 18:41, 26 November 2018

Endometrial cancer Microchapters

Home

Patient Information

Overview

Historical perspective

Classification

Pathophysiology

Causes

Differentiating Endometrial cancer from other Diseases

Epidemiology and Demographics

Risk factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

Ultrasound

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Future or Investigational Therapies

Case Studies

Case #1

Endometrial cancer classification On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Endometrial cancer classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Endometrial cancer classification

CDC on Endometrial cancer classification

Endometrial cancer classification in the news

Blogs on Endometrial cancer classification

Directions to Hospitals Treating Endometrial cancer

Risk calculators and risk factors for Endometrial cancer classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.

Classification

Endometrial cancer may be classified according to histology into 2 types:[1]

Type Histology Prognosis Pathogenesis Prevalence
Type I Endometroid (adenocarcinoma) Favorable (estrogen-responsive) • May arise from atypical hyperplasia
• Linked to unopposed estrogen stimulation
80%
Type II • Endometroid
• Serous
• Clear cell
• Mucinous
• Squamous
• Mesonephric
• Undifferentiated
Typically bad prognosis • Develops from atrophic endometrium
• Not linked to hormonally driven pathogenesis
15-20%

References

  1. Bokhman JV (1983). "Two pathogenetic types of endometrial carcinoma". Gynecol Oncol. 15 (1): 10–7. PMID 6822361.


Template:WikiDoc Sources