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{{Endometrial cancer}}
{{Endometrial cancer}}
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==Overview==
==Overview==
Endometrial cancer may be classified according to histology into 7 subtypes: endometrioid, uterine papillary [[serous]], mucinous,  clear cell, [[squamous cell]], mixed and undifferentiated.
Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.


==Classification==
==Classification==
* Endometrial cancers are classified in one of the following two categories:<ref>{{Cite web | title = endometrial cancer classification | url =http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_9 }}</ref>
Endometrial cancer may be classified according to histology into 2 types:<ref name="pmid6822361">{{cite journal| author=Bokhman JV| title=Two pathogenetic types of endometrial carcinoma. | journal=Gynecol Oncol | year= 1983 | volume= 15 | issue= 1 | pages= 10-7 | pmid=6822361 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6822361  }} </ref>
:* Type 1 may arise from complex atypical [[hyperplasia]] and is pathogenetically linked to unopposed estrogenic stimulation.
{| class="wikitable"
:* Type 2 develops from atrophic [[endometrium]] and is not linked to hormonally driven pathogenesis.
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Type
'''Cellular Classification of Endometrial Cancer'''
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Histology
: 1. Endometrioid (75%–80%), (The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant [[glandular]] epithelial elements)
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Prognosis
::* Ciliated adenocarcinoma
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Pathogenesis
::* Secretory adenocarcinoma
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Prevalence
::* [[Papillary]] or villoglandular
|-
::* Adenocarcinoma with squamous differentiation
| style="background:#DCDCDC;" align="center" + |Type I
:::* Adenoacanthoma
| style="background:#F5F5F5;" align="center" + |Endometroid (adenocarcinoma)
:::* Adenosquamous (Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium)
| style="background:#F5F5F5;" align="center" + |Favorable (estrogen-responsive)
: 2. Uterine papillary serous (<10%)
| style="background:#F5F5F5;" align="left" + |• May arise from atypical hyperplasia <br> • Linked to unopposed estrogen stimulation
: 3. Mucinous (1%)
| style="background:#F5F5F5;" align="center" + |80%  
: 4. Clear cell (4%)
|-
: 5. [[Squamous cell]] (<1%)
| style="background:#DCDCDC;" align="center" + |Type II
: 6. Mixed (10%)
| style="background:#F5F5F5;" align="left" + |• Endometroid <br>• Serous <br>• Clear cell <br>• Mucinous <br>• Squamous <br>• Mesonephric <br>• Undifferentiated
: 7. Undifferentiated
| style="background:#F5F5F5;" align="center" + |Typically bad prognosis
| style="background:#F5F5F5;" align="left" + |• Develops from atrophic endometrium <br>• Not linked to hormonally driven pathogenesis
| style="background:#F5F5F5;" align="center" + |15-20%
|}


==References==
==References==
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Latest revision as of 18:41, 26 November 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.

Classification

Endometrial cancer may be classified according to histology into 2 types:[1]

Type Histology Prognosis Pathogenesis Prevalence
Type I Endometroid (adenocarcinoma) Favorable (estrogen-responsive) • May arise from atypical hyperplasia
• Linked to unopposed estrogen stimulation
80%
Type II • Endometroid
• Serous
• Clear cell
• Mucinous
• Squamous
• Mesonephric
• Undifferentiated
Typically bad prognosis • Develops from atrophic endometrium
• Not linked to hormonally driven pathogenesis
15-20%

References

  1. Bokhman JV (1983). "Two pathogenetic types of endometrial carcinoma". Gynecol Oncol. 15 (1): 10–7. PMID 6822361.


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