Endometrial cancer classification: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
 
(28 intermediate revisions by 4 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Endometrial cancer}}
{{Endometrial cancer}}
{{CMG}}
{{CMG}}{{AE}}{{RAK}}


==Overview==
==Overview==
Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.
==Classification==
==Classification==
Most endometrial cancers are [[carcinoma]]s (usually [[adenocarcinoma]]s), meaning that they originate from the single layer of [[epithelium|epithelial]] cells which line the endometrium and form the endometrial glands. There are many [[histopathology|microscopic]] subtypes of ''endometrial carcinoma'', including the common ''endometrioid'' type, in which the cancer cells grow in patterns reminiscent of normal endometrium, and the far more aggressive ''papillary serous'' and ''clear cell'' endometrial carcinomas. Some authorities have proposed that endometrial carcinomas be classified into two pathogenetic groups:<ref>{{cite journal |author=Bokhman JV |title=Two pathogenetic types of endometrial carcinoma |journal=Gynecol. Oncol. |volume=15 |issue=1 |pages=10-7 |year=1983 |pmid=6822361 |doi=}}</ref>
Endometrial cancer may be classified according to histology into 2 types:<ref name="pmid6822361">{{cite journal| author=Bokhman JV| title=Two pathogenetic types of endometrial carcinoma. | journal=Gynecol Oncol | year= 1983 | volume= 15 | issue= 1 | pages= 10-7 | pmid=6822361 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6822361  }} </ref>
 
{| class="wikitable"
====Type I:====
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Type
These cancers occur most commonly in pre- and peri-[[menopause|menopausal]] women, often with a history of unopposed [[estrogen]] exposure and/or [[endometrial hyperplasia]]. They are often minimally invasive into the underlying uterine wall, are of the ''[[Grading (tumors)|low-grade]] endometrioid'' type, and carry a good prognosis.
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Histology
 
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Prognosis
====Type II:====
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Pathogenesis
These cancers occur in older, post-menopausal women, are more common in African-Americans, and are not associated with increased exposure to estrogen. They are typically of the ''[[Grading (tumors)|high-grade]] endometrioid'', ''papillary serous'' or ''clear cell'' types, and carry a generally poor prognosis
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Prevalence
 
|-
In contrast to ''endometrial carcinomas'', the uncommon ''endometrial stromal [[sarcomas]]'' are cancers which originate in the non-glandular [[connective tissue]] of the endometrium. ''Malignant mixed müllerian tumor'' is a rare endometrial cancer which contains cancerous cells of both glandular and [[connective tissue]] appearance - in this case, the cell of origin is unknown.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref>
| style="background:#DCDCDC;" align="center" + |Type I
 
| style="background:#F5F5F5;" align="center" + |Endometroid (adenocarcinoma)
<gallery>
| style="background:#F5F5F5;" align="center" + |Favorable (estrogen-responsive)
Image:Endometrial stromal sarcoma gross.jpg|Endometrial stromal sarcoma
| style="background:#F5F5F5;" align="left" + |• May arise from atypical hyperplasia <br> • Linked to unopposed estrogen stimulation
Image:Uterine carcinosarcoma.jpg|Malignant mixed müllerian tumor
| style="background:#F5F5F5;" align="center" + |80%
</gallery>
|-
| style="background:#DCDCDC;" align="center" + |Type II
| style="background:#F5F5F5;" align="left" + |• Endometroid <br>• Serous <br>• Clear cell <br>• Mucinous <br>• Squamous <br>• Mesonephric <br>• Undifferentiated
| style="background:#F5F5F5;" align="center" + |Typically bad prognosis
| style="background:#F5F5F5;" align="left" + |• Develops from atrophic endometrium <br>• Not linked to hormonally driven pathogenesis
| style="background:#F5F5F5;" align="center" + |15-20%
|}


==References==
==References==
Line 29: Line 37:
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Gynecology]]
[[Category:Surgery]]

Latest revision as of 18:41, 26 November 2018

Endometrial cancer Microchapters

Home

Patient Information

Overview

Historical perspective

Classification

Pathophysiology

Causes

Differentiating Endometrial cancer from other Diseases

Epidemiology and Demographics

Risk factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

Ultrasound

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Future or Investigational Therapies

Case Studies

Case #1

Endometrial cancer classification On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Endometrial cancer classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Endometrial cancer classification

CDC on Endometrial cancer classification

Endometrial cancer classification in the news

Blogs on Endometrial cancer classification

Directions to Hospitals Treating Endometrial cancer

Risk calculators and risk factors for Endometrial cancer classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.

Classification

Endometrial cancer may be classified according to histology into 2 types:[1]

Type Histology Prognosis Pathogenesis Prevalence
Type I Endometroid (adenocarcinoma) Favorable (estrogen-responsive) • May arise from atypical hyperplasia
• Linked to unopposed estrogen stimulation
80%
Type II • Endometroid
• Serous
• Clear cell
• Mucinous
• Squamous
• Mesonephric
• Undifferentiated
Typically bad prognosis • Develops from atrophic endometrium
• Not linked to hormonally driven pathogenesis
15-20%

References

  1. Bokhman JV (1983). "Two pathogenetic types of endometrial carcinoma". Gynecol Oncol. 15 (1): 10–7. PMID 6822361.


Template:WikiDoc Sources