Creutzfeldt-Jakob disease MRI: Difference between revisions

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==Overview==
==Overview==
MRI findings in CJD include high signal abnormalities in [[caudate nucleus]] and/or [[putamen]] on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR).<ref name="www.cdc.gov">{{Cite web  | last =  | first =  | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher =  | date =  | accessdate = 17 February 2014 }}</ref> Additional findings on diffusion weighted imaging include cortical, subcortical, and thalamic involvement. An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease.
MRI findings in CJD include high signal abnormalities in [[caudate nucleus]] and/or [[putamen]] on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR).<ref name="www.cdc.gov">{{Cite web  | last =  | first =  | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher =  | date =  | accessdate = 17 February 2014 }}</ref> Additional findings on diffusion weighted imaging include cortical, subcortical, and thalamic involvement. An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for [[variant Creutzfeldt-Jakob disease]].


== MRI==
== MRI==
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:*Cortical hyperintensity (25%-70% of cases)
:*Cortical hyperintensity (25%-70% of cases)
:*Subcortical abnormalities (5% of cases)
:*Subcortical abnormalities (5% of cases)
:*Thalamic involvement, usually in posterior thalamus (more strongly associated with variant Creutzfeldt-Jakob disease than with classic Creutzfeldt-Jakob disease)<ref>{{cite journal  | last =Tschampa  | first =Henriette J.  |authorlink =  | coauthors =Petra Mürtz, Sebastian Flacke, Sebastian Paus, Hans H. Schild and Horst Urbach  | title =Thalamic Involvement in Sporadic Creutzfeldt-Jakob Disease: A Diffusion-Weighted MR Imaging Study  | journal =American Journal of Neuroradiology  | volume =24  | pages =908-915  | publisher =American Society of Neuroradiology  |date=May 2003  | url =http://www.ajnr.org/cgi/content/full/24/5/908  | accessdate =  2007-10-30}}</ref>
:*Thalamic involvement, usually in posterior thalamus (more strongly associated with [[variant Creutzfeldt-Jakob disease]] than with classic Creutzfeldt-Jakob disease)<ref>{{cite journal  | last =Tschampa  | first =Henriette J.  |authorlink =  | coauthors =Petra Mürtz, Sebastian Flacke, Sebastian Paus, Hans H. Schild and Horst Urbach  | title =Thalamic Involvement in Sporadic Creutzfeldt-Jakob Disease: A Diffusion-Weighted MR Imaging Study  | journal =American Journal of Neuroradiology  | volume =24  | pages =908-915  | publisher =American Society of Neuroradiology  |date=May 2003  | url =http://www.ajnr.org/cgi/content/full/24/5/908  | accessdate =  2007-10-30}}</ref>
*An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease.
*An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease.
==References==
==References==

Revision as of 05:00, 30 October 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

MRI findings in CJD include high signal abnormalities in caudate nucleus and/or putamen on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR).[1] Additional findings on diffusion weighted imaging include cortical, subcortical, and thalamic involvement. An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease.

MRI

  • Cortical hyperintensity (25%-70% of cases)
  • Subcortical abnormalities (5% of cases)
  • Thalamic involvement, usually in posterior thalamus (more strongly associated with variant Creutzfeldt-Jakob disease than with classic Creutzfeldt-Jakob disease)[3]
  • An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease.

References

  1. "http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html". Retrieved 17 February 2014. External link in |title= (help)
  2. Young, Geoffrey S. (June–July 2005). "Diffusion-Weighted and Fluid-Attenuated Inversion Recovery Imaging in Creutzfeldt-Jakob Disease: High Sensitivity and Specificity for Diagnosis". American Journal of Neuroradiology. American Society of Neuroradiology. 26: 1551–1562. Retrieved 2007-10-30. Unknown parameter |coauthors= ignored (help)
  3. Tschampa, Henriette J. (May 2003). "Thalamic Involvement in Sporadic Creutzfeldt-Jakob Disease: A Diffusion-Weighted MR Imaging Study". American Journal of Neuroradiology. American Society of Neuroradiology. 24: 908–915. Retrieved 2007-10-30. Unknown parameter |coauthors= ignored (help)


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