Henoch-Schönlein purpura history and symptoms: Difference between revisions

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==Symptoms==
==Symptoms==
[[Purpura]], [[arthritis]] and [[abdominal pain]] are known as the "classic triad" of Henoch-Schönlein purpura.<ref name=Kraft1998>{{cite journal |author=Kraft DM, Mckee D, Scott C |title=Henoch-Schönlein purpura: a review |journal=Am Fam Physician|volume=58 |issue=2 |pages=405–8, 411 |year=1998 |pmid=9713395 |url=http://www.aafp.org/afp/980800ap/kraft.html}}</ref> Purpura occur in all cases, joint pains and arthritis in 80%, and abdominal pain in 62%. Some include [[Gastrointestinal bleeding|gastrointestinal hemorrhage]] as a fourth criterion - this occurs in 33% of cases (sometimes but not necessarily due to [[Intussusception (medical disorder)|intussusception]]).<ref name=Saulsbury1999>{{cite journal |author=Saulsbury FT |title=Henoch-Schönlein purpura in children. Report of 100 patients and review of the literature |journal=Medicine (Baltimore) |volume=78 |issue=6 |pages=395–409 |year=1999|pmid=10575422 |doi=}}</ref> The purpura typically appear on the legs and buttocks, but may also be seen on the arms, face and trunk. The abdominal pain is [[colic]]ky in character. The joints involved tend to be the [[ankle]]s, [[knee]]s, and [[elbow]]s but arthritis in the hands and feet is possible; the arthritis is non-erosive and hence causes no permanent deformity.<ref name=Kraft1998/> 40% have evidence of [[kidney]] involvement, mainly in the form of [[hematuria]] (blood in the urine), but only a quarter will have this in sufficient quantities to be noticeable without laboratory tests.<ref name=Saulsbury1999/> Problems in other organs, such as the [[central nervous system]] (brain and spinal cord) and [[lung]]s may occur, but much less commonly than the skin, bowel and kidneys.. The disease tends to last about 4 weeks, and then resolves spontaneously.
On the basis of symptoms, it is possible to distinguish HSP from [[hypersensitivity vasculitis]] (HV). In a series comparing 85 HSP patients with 93 HV patients, five symptoms were found to be indicative of HSP: palpable purpura, [[abdominal angina]], digestive tract hemorrhage (not due to intussussception), hematuria and age less than 20. The presence of three or more of these indicators has an 87% [[Sensitivity (tests)|sensitivity]] for predicting HSP.<ref name="pmid1613701">{{cite journal |author=Michel BA, Hunder GG, Bloch DA, Calabrese LH |title=Hypersensitivity vasculitis and Henoch-Schönlein purpura: a comparison between the 2 disorders|journal=J. Rheumatol. |volume=19 |issue=5 |pages=721–8 |year=1992 |pmid=1613701}}</ref>


==References==
==References==

Revision as of 01:55, 6 February 2018

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