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{{ | '''E3 ubiquitin-protein ligase BRE1A''' is an [[enzyme]] that in humans is encoded by the ''RNF20'' [[gene]].<ref name="pmid16337599">{{cite journal | vauthors = Kim J, Hake SB, Roeder RG | title = The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions | journal = Mol Cell | volume = 20 | issue = 5 | pages = 759–70 |date=Dec 2005 | pmid = 16337599 | pmc = | doi = 10.1016/j.molcel.2005.11.012 }}</ref><ref name="pmid12876294">{{cite journal | vauthors = Wood A, Schneider J, Dover J, Johnston M, Shilatifard A | title = The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p | journal = J Biol Chem | volume = 278 | issue = 37 | pages = 34739–42 |date=Sep 2003 | pmid = 12876294 | pmc = | doi = 10.1074/jbc.C300269200 }}</ref><ref name="pmid18832071">{{cite journal | vauthors = Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M | title = The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression | journal = Genes Dev | volume = 22 | issue = 19 | pages = 2664–76 |date=Oct 2008 | pmid = 18832071 | pmc = 2559905 | doi = 10.1101/gad.1703008 }}</ref><ref name="pmid19037095">{{cite journal | vauthors = Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K | title = Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor | journal = Mol Biol Cell | volume = 20 | issue = 3 | pages = 757–68 |date=Feb 2009 | pmid = 19037095 | pmc = 2633391 | doi = 10.1091/mbc.E08-09-0983 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RNF20 ring finger protein 20| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56254| accessdate = }}</ref> | ||
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| summary_text = The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.<ref name="entrez">{{cite web | title = Entrez Gene: RNF20 ring finger protein 20| url = | | summary_text = The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.<ref name="entrez">{{cite web | title = Entrez Gene: RNF20 ring finger protein 20| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56254| accessdate = }}</ref> | ||
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==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
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*{{cite journal | *{{cite journal |vauthors=Lossos IS, Alizadeh AA, Eisen MB, etal |title=Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 18 |pages= 10209–13 |year= 2000 |pmid= 10954754 |doi= 10.1073/pnas.180316097 | pmc=27813 }} | ||
*{{cite journal | *{{cite journal |vauthors=Slachta CA, Jeevanandam V, Goldman B, etal |title=Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries). |journal=J. Immunol. |volume=165 |issue= 6 |pages= 3469–83 |year= 2000 |pmid= 10975868 |doi= 10.4049/jimmunol.165.6.3469}} | ||
*{{cite journal | | *{{cite journal | vauthors=Lee J, Monson NL, Lipsky PE |title=The V lambda J lambda repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing. |journal=J. Immunol. |volume=165 |issue= 11 |pages= 6322–33 |year= 2001 |pmid= 11086069 |doi= 10.4049/jimmunol.165.11.6322}} | ||
*{{cite journal | *{{cite journal |vauthors=Rowley AH, Shulman ST, Spike BT, etal |title=Oligoclonal IgA response in the vascular wall in acute Kawasaki disease. |journal=J. Immunol. |volume=166 |issue= 2 |pages= 1334–43 |year= 2001 |pmid= 11145718 |doi= 10.4049/jimmunol.166.2.1334}} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Hwang WW, Venkatasubrahmanyam S, Ianculescu AG, etal |title=A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. |journal=Mol. Cell |volume=11 |issue= 1 |pages= 261–6 |year= 2003 |pmid= 12535538 |doi=10.1016/S1097-2765(02)00826-2 }} | ||
*{{cite journal | *{{cite journal |vauthors=Wood A, Krogan NJ, Dover J, etal |title=Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. |journal=Mol. Cell |volume=11 |issue= 1 |pages= 267–74 |year= 2003 |pmid= 12535539 |doi=10.1016/S1097-2765(02)00802-X }} | ||
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | |||
*{{cite journal | *{{cite journal |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 }} | ||
*{{cite journal | *{{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }} | ||
*{{cite journal | *{{cite journal |vauthors=Zhu B, Zheng Y, Pham AD, etal |title=Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. |journal=Mol. Cell |volume=20 |issue= 4 |pages= 601–11 |year= 2006 |pmid= 16307923 |doi= 10.1016/j.molcel.2005.09.025 }} | ||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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* {{MeshName|RNF20+protein,+human}} | * {{MeshName|RNF20+protein,+human}} | ||
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[[Category:RING finger proteins]] | |||
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Latest revision as of 09:21, 10 September 2017
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| Location (UCSC) | n/a | n/a | |||||
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E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.[1][2][3][4][5]
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.[5]
See also
References
- ↑ Kim J, Hake SB, Roeder RG (Dec 2005). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions". Mol Cell. 20 (5): 759–70. doi:10.1016/j.molcel.2005.11.012. PMID 16337599.
- ↑ Wood A, Schneider J, Dover J, Johnston M, Shilatifard A (Sep 2003). "The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p". J Biol Chem. 278 (37): 34739–42. doi:10.1074/jbc.C300269200. PMID 12876294.
- ↑ Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M (Oct 2008). "The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression". Genes Dev. 22 (19): 2664–76. doi:10.1101/gad.1703008. PMC 2559905. PMID 18832071.
- ↑ Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K (Feb 2009). "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor". Mol Biol Cell. 20 (3): 757–68. doi:10.1091/mbc.E08-09-0983. PMC 2633391. PMID 19037095.
- ↑ 5.0 5.1 "Entrez Gene: RNF20 ring finger protein 20".
Further reading
- Lossos IS, Alizadeh AA, Eisen MB, et al. (2000). "Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas". Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10209–13. doi:10.1073/pnas.180316097. PMC 27813. PMID 10954754.
- Slachta CA, Jeevanandam V, Goldman B, et al. (2000). "Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries)". J. Immunol. 165 (6): 3469–83. doi:10.4049/jimmunol.165.6.3469. PMID 10975868.
- Lee J, Monson NL, Lipsky PE (2001). "The V lambda J lambda repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing". J. Immunol. 165 (11): 6322–33. doi:10.4049/jimmunol.165.11.6322. PMID 11086069.
- Rowley AH, Shulman ST, Spike BT, et al. (2001). "Oligoclonal IgA response in the vascular wall in acute Kawasaki disease". J. Immunol. 166 (2): 1334–43. doi:10.4049/jimmunol.166.2.1334. PMID 11145718.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hwang WW, Venkatasubrahmanyam S, Ianculescu AG, et al. (2003). "A conserved RING finger protein required for histone H2B monoubiquitination and cell size control". Mol. Cell. 11 (1): 261–6. doi:10.1016/S1097-2765(02)00826-2. PMID 12535538.
- Wood A, Krogan NJ, Dover J, et al. (2003). "Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter". Mol. Cell. 11 (1): 267–74. doi:10.1016/S1097-2765(02)00802-X. PMID 12535539.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Zhu B, Zheng Y, Pham AD, et al. (2006). "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation". Mol. Cell. 20 (4): 601–11. doi:10.1016/j.molcel.2005.09.025. PMID 16307923.
External links
- RNF20+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
 | This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it. |