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{{Infobox_gene}}
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'''Histone H2B type 1-C/E/F/G/I''' is a [[protein]] that in humans is encoded by the ''HIST1H2BG'' [[gene]].<ref name="pmid1916825">{{cite journal |vauthors=Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D | title = Isolation and characterization of two human H1 histone genes within clusters of core histone genes | journal = Genomics | volume = 10 | issue = 4 | pages = 940–8 |date=Nov 1991 | pmid = 1916825 | pmc =  | doi =10.1016/0888-7543(91)90183-F }}</ref><ref name="pmid12408966">{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=Oct 2002 | pmid = 12408966 | pmc =  | doi =10.1016/S0888-7543(02)96850-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2BG histone cluster 1, H2bg| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8339| accessdate = }}</ref>
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| image = PBB_Protein_HIST1H2BG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aoi.
| PDB = {{PDB2|1aoi}}, {{PDB2|1eqz}}, {{PDB2|1f66}}, {{PDB2|1hio}}, {{PDB2|1hq3}}, {{PDB2|1kx3}}, {{PDB2|1kx4}}, {{PDB2|1kx5}}, {{PDB2|1m18}}, {{PDB2|1m19}}, {{PDB2|1m1a}}, {{PDB2|1p34}}, {{PDB2|1p3a}}, {{PDB2|1p3b}}, {{PDB2|1p3f}}, {{PDB2|1p3g}}, {{PDB2|1p3i}}, {{PDB2|1p3k}}, {{PDB2|1p3l}}, {{PDB2|1p3m}}, {{PDB2|1p3o}}, {{PDB2|1p3p}}, {{PDB2|1s32}}, {{PDB2|1tzy}}, {{PDB2|1u35}}, {{PDB2|1zbb}}, {{PDB2|1zla}}, {{PDB2|2aro}}, {{PDB2|2cv5}}, {{PDB2|2f8n}}, {{PDB2|2fj7}}, {{PDB2|2hio}}, {{PDB2|2nzd}}
| Name = Histone cluster 1, H2bg
| HGNCid = 4746
| Symbol = HIST1H2BG
| AltSymbols =; H2B.1A; H2B/a; H2BFA; HIST1H2BF; HIST1H2BI; dJ221C16.8
| OMIM = 602798
| ECnumber =
| Homologene = 86899
| MGIid = 2448404
  | Function =  
  | Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8339
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_003509
    | Hs_RefseqmRNA = NM_003518
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =
    | Hs_GenLoc_end =
    | Hs_Uniprot =   
    | Mm_EntrezGene = 319186
    | Mm_Ensembl = ENSMUSG00000058189
    | Mm_RefseqmRNA = NM_178200
    | Mm_RefseqProtein = NP_835507
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 21729563
    | Mm_GenLoc_end = 21729943
    | Mm_Uniprot = P10854
  }}
}}
'''Histone cluster 1, H2bg''', also known as '''HIST1H2BG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2BG histone cluster 1, H2bg| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8339| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3,  and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2BG histone cluster 1, H2bg| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8339| accessdate = }}</ref>
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3,  and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2BG histone cluster 1, H2bg| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8339| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ohe Y, Hayashi H, Iwai K |title=Human spleen histone H2B. Isolation and amino acid sequence. |journal=J. Biochem. |volume=85 |issue= 2 |pages= 615-24 |year= 1979 |pmid= 422550 |doi=  }}
*{{cite journal  |vauthors=Ohe Y, Hayashi H, Iwai K |title=Human spleen histone H2B. Isolation and amino acid sequence. |journal=J. Biochem. |volume=85 |issue= 2 |pages= 615–24 |year= 1979 |pmid= 422550 |doi=  }}
*{{cite journal | author=Albig W, Kardalinou E, Drabent B, ''et al.'' |title=Isolation and characterization of two human H1 histone genes within clusters of core histone genes. |journal=Genomics |volume=10 |issue= 4 |pages= 940-8 |year= 1991 |pmid= 1916825 |doi=  }}
*{{cite journal   |vauthors=Frohm M, Gunne H, Bergman AC, etal |title=Biochemical and antibacterial analysis of human wound and blister fluid. |journal=Eur. J. Biochem. |volume=237 |issue= 1 |pages= 86–92 |year= 1996 |pmid= 8620898 |doi=10.1111/j.1432-1033.1996.0086n.x }}
*{{cite journal  | author=Frohm M, Gunne H, Bergman AC, ''et al.'' |title=Biochemical and antibacterial analysis of human wound and blister fluid. |journal=Eur. J. Biochem. |volume=237 |issue= 1 |pages= 86-92 |year= 1996 |pmid= 8620898 |doi=  }}
*{{cite journal  |vauthors=Díaz-Jullien C, Pérez-Estévez A, Covelo G, Freire M |title=Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay. |journal=Biochim. Biophys. Acta |volume=1296 |issue= 2 |pages= 219–27 |year= 1996 |pmid= 8814229 |doi=  10.1016/0167-4838(96)00072-6}}
*{{cite journal  | author=Díaz-Jullien C, Pérez-Estévez A, Covelo G, Freire M |title=Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay. |journal=Biochim. Biophys. Acta |volume=1296 |issue= 2 |pages= 219-27 |year= 1996 |pmid= 8814229 |doi=  }}
*{{cite journal   |vauthors=Albig W, Kioschis P, Poustka A, etal |title=Human histone gene organization: nonregular arrangement within a large cluster. |journal=Genomics |volume=40 |issue= 2 |pages= 314–22 |year= 1997 |pmid= 9119399 |doi= 10.1006/geno.1996.4592 }}
*{{cite journal | author=Albig W, Kioschis P, Poustka A, ''et al.'' |title=Human histone gene organization: nonregular arrangement within a large cluster. |journal=Genomics |volume=40 |issue= 2 |pages= 314-22 |year= 1997 |pmid= 9119399 |doi= 10.1006/geno.1996.4592 }}
*{{cite journal  |vauthors=Albig W, Doenecke D |title=The human histone gene cluster at the D6S105 locus. |journal=Hum. Genet. |volume=101 |issue= 3 |pages= 284–94 |year= 1998 |pmid= 9439656 |doi=10.1007/s004390050630 }}
*{{cite journal  | author=Albig W, Doenecke D |title=The human histone gene cluster at the D6S105 locus. |journal=Hum. Genet. |volume=101 |issue= 3 |pages= 284-94 |year= 1998 |pmid= 9439656 |doi=  }}
*{{cite journal  |vauthors=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi= 10.1128/mcb.18.5.2535| pmc=110633 }}
*{{cite journal  | author=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535-44 |year= 1998 |pmid= 9566873 |doi=  }}
*{{cite journal   |vauthors=Piredda L, Farrace MG, Lo Bello M, etal |title=Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis. |journal=FASEB J. |volume=13 |issue= 2 |pages= 355–64 |year= 1999 |pmid= 9973324 |doi=  }}
*{{cite journal | author=Piredda L, Farrace MG, Lo Bello M, ''et al.'' |title=Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis. |journal=FASEB J. |volume=13 |issue= 2 |pages= 355-64 |year= 1999 |pmid= 9973324 |doi=  }}
*{{cite journal   |vauthors=Deng L, de la Fuente C, Fu P, etal |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 }}
*{{cite journal | author=Deng L, de la Fuente C, Fu P, ''et al.'' |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278-95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 }}
*{{cite journal   |vauthors=Deng L, Wang D, de la Fuente C, etal |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 }}
*{{cite journal | author=Deng L, Wang D, de la Fuente C, ''et al.'' |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312-26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 }}
*{{cite journal   |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal   |vauthors=Kim HS, Cho JH, Park HW, etal |title=Endotoxin-neutralizing antimicrobial proteins of the human placenta. |journal=J. Immunol. |volume=168 |issue= 5 |pages= 2356–64 |year= 2002 |pmid= 11859126 |doi=  10.4049/jimmunol.168.5.2356}}
*{{cite journal | author=Kim HS, Cho JH, Park HW, ''et al.'' |title=Endotoxin-neutralizing antimicrobial proteins of the human placenta. |journal=J. Immunol. |volume=168 |issue= 5 |pages= 2356-64 |year= 2002 |pmid= 11859126 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Marzluff WF, Gongidi P, Woods KR, ''et al.'' |title=The human and mouse replication-dependent histone genes. |journal=Genomics |volume=80 |issue= 5 |pages= 487-98 |year= 2003 |pmid= 12408966 |doi=  }}
*{{cite journal   |vauthors=Cheung WL, Ajiro K, Samejima K, etal |title=Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. |journal=Cell |volume=113 |issue= 4 |pages= 507–17 |year= 2003 |pmid= 12757711 |doi=10.1016/S0092-8674(03)00355-6 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Tollin M, Bergman P, Svenberg T, etal |title=Antimicrobial peptides in the first line defence of human colon mucosa. |journal=Peptides |volume=24 |issue= 4 |pages= 523–30 |year= 2004 |pmid= 12860195 |doi=10.1016/S0196-9781(03)00114-1 }}
*{{cite journal | author=Cheung WL, Ajiro K, Samejima K, ''et al.'' |title=Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. |journal=Cell |volume=113 |issue= 4 |pages= 507-17 |year= 2003 |pmid= 12757711 |doi=  }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Tollin M, Bergman P, Svenberg T, ''et al.'' |title=Antimicrobial peptides in the first line defence of human colon mucosa. |journal=Peptides |volume=24 |issue= 4 |pages= 523-30 |year= 2004 |pmid= 12860195 |doi=  }}
*{{cite journal   |vauthors=Coleman MA, Miller KA, Beernink PT, etal |title=Identification of chromatin-related protein interactions using protein microarrays. |journal=Proteomics |volume=3 |issue= 11 |pages= 2101–7 |year= 2004 |pmid= 14595808 |doi= 10.1002/pmic.200300593 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  |vauthors=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550–61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631 | pmc=291826 }}
*{{cite journal | author=Coleman MA, Miller KA, Beernink PT, ''et al.'' |title=Identification of chromatin-related protein interactions using protein microarrays. |journal=Proteomics |volume=3 |issue= 11 |pages= 2101-7 |year= 2004 |pmid= 14595808 |doi= 10.1002/pmic.200300593 }}
*{{cite journal  |vauthors=Howell SJ, Wilk D, Yadav SP, Bevins CL |title=Antimicrobial polypeptides of the human colonic epithelium. |journal=Peptides |volume=24 |issue= 11 |pages= 1763–70 |year= 2004 |pmid= 15019208 |doi= 10.1016/j.peptides.2003.07.028 }}
*{{cite journal  | author=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550-61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631 }}
*{{cite journal  | author=Howell SJ, Wilk D, Yadav SP, Bevins CL |title=Antimicrobial polypeptides of the human colonic epithelium. |journal=Peptides |volume=24 |issue= 11 |pages= 1763-70 |year= 2004 |pmid= 15019208 |doi= 10.1016/j.peptides.2003.07.028 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=8339}}
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Latest revision as of 13:39, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BG gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[3]

References

  1. ↑ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
  2. ↑ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  3. ↑ 3.0 3.1 "Entrez Gene: HIST1H2BG histone cluster 1, H2bg".

Further reading



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