RILP (gene): Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Rab-interacting lysosomal protein''' is a [[protein]] that in humans is encoded by the ''RILP'' [[gene]].<ref name="pmid11179213">{{cite journal | vauthors = Cantalupo G, Alifano P, Roberti V, Bruni CB, Bucci C | title = Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes | journal = EMBO J | volume = 20 | issue = 4 | pages = 683–93 | date = February 2001 | pmid = 11179213 | pmc = 145419 | doi = 10.1093/emboj/20.4.683 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RILP Rab interacting lysosomal protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83547| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RILP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yhn.
| PDB = {{PDB2|1yhn}}
| Name = Rab interacting lysosomal protein
| HGNCid = 30266
| Symbol = RILP
| AltSymbols =; FLJ31193; PP10141
| OMIM = 607848
| ECnumber = 
| Homologene = 19596
| MGIid = 2144271
| Function = {{GNF_GO|id=GO:0017137 |text = Rab GTPase binding}}
| Component = {{GNF_GO|id=GO:0005765 |text = lysosomal membrane}} {{GNF_GO|id=GO:0005770 |text = late endosome}}
| Process = {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 83547
    | Hs_Ensembl = ENSG00000167705
    | Hs_RefseqProtein = NP_113618
    | Hs_RefseqmRNA = NM_031430
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 1496194
    | Hs_GenLoc_end = 1500142
    | Hs_Uniprot = Q96NA2
    | Mm_EntrezGene = 280408
    | Mm_Ensembl = ENSMUSG00000038195
    | Mm_RefseqmRNA = NM_001029938
    | Mm_RefseqProtein = NP_001025109
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 75326289
    | Mm_GenLoc_end = 75329363
    | Mm_Uniprot = Q14AQ2
  }}
}}
'''Rab interacting lysosomal protein''', also known as '''RILP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RILP Rab interacting lysosomal protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83547| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
RILP, along with the GTPase RAB7 (MIM 602298), controls late endocytic transport.[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = RILP, along with the GTPase RAB7 (MIM 602298), controls late endocytic transport.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RILP Rab interacting lysosomal protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83547| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Cantalupo G, Alifano P, Roberti V, ''et al.'' |title=Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. |journal=EMBO J. |volume=20 |issue= 4 |pages= 683-93 |year= 2001 |pmid= 11179213 |doi= 10.1093/emboj/20.4.683 }}
*{{cite journal  | author=Bucci C, De Gregorio L, Bruni CB |title=Expression analysis and chromosomal assignment of PRA1 and RILP genes. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 4 |pages= 815-9 |year= 2001 |pmid= 11520070 |doi= 10.1006/bbrc.2001.5466 }}
*{{cite journal  | author=Jordens I, Fernandez-Borja M, Marsman M, ''et al.'' |title=The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors. |journal=Curr. Biol. |volume=11 |issue= 21 |pages= 1680-5 |year= 2002 |pmid= 11696325 |doi=  }}
*{{cite journal  | author=Wang T, Hong W |title=Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4317-32 |year= 2003 |pmid= 12475955 |doi= 10.1091/mbc.E02-05-0280 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Cardoso C, Leventer RJ, Ward HL, ''et al.'' |title=Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 918-30 |year= 2003 |pmid= 12621583 |doi=  }}
*{{cite journal  | author=Harrison RE, Bucci C, Vieira OV, ''et al.'' |title=Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP. |journal=Mol. Cell. Biol. |volume=23 |issue= 18 |pages= 6494-506 |year= 2003 |pmid= 12944476 |doi=  }}
*{{cite journal  | author=Wang T, Wong KK, Hong W |title=A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. |journal=Mol. Biol. Cell |volume=15 |issue= 2 |pages= 815-26 |year= 2004 |pmid= 14668488 |doi= 10.1091/mbc.E03-06-0413 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wan D, Gong Y, Qin W, ''et al.'' |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724-9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 }}
*{{cite journal  | author=Wu M, Wang T, Loh E, ''et al.'' |title=Structural basis for recruitment of RILP by small GTPase Rab7. |journal=EMBO J. |volume=24 |issue= 8 |pages= 1491-501 |year= 2005 |pmid= 15933719 |doi= 10.1038/sj.emboj.7600643 }}
*{{cite journal  | author=Colucci AM, Campana MC, Bellopede M, Bucci C |title=The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction. |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 1 |pages= 128-33 |year= 2005 |pmid= 15996637 |doi= 10.1016/j.bbrc.2005.06.067 }}
*{{cite journal  | author=Shimojo M, Hersh LB |title=Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF. |journal=J. Neurochem. |volume=96 |issue= 4 |pages= 1130-8 |year= 2006 |pmid= 16417580 |doi= 10.1111/j.1471-4159.2005.03608.x }}
*{{cite journal  | author=Marsman M, Jordens I, Rocha N, ''et al.'' |title=A splice variant of RILP induces lysosomal clustering independent of dynein recruitment. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 3 |pages= 747-56 |year= 2006 |pmid= 16631113 |doi= 10.1016/j.bbrc.2006.03.178 }}
*{{cite journal  | author=Progida C, Spinosa MR, De Luca A, Bucci C |title=RILP interacts with the VPS22 component of the ESCRT-II complex. |journal=Biochem. Biophys. Res. Commun. |volume=347 |issue= 4 |pages= 1074-9 |year= 2006 |pmid= 16857164 |doi= 10.1016/j.bbrc.2006.07.007 }}
}}
{{refend}}


{{protein-stub}}
RILP (gene) has been shown to [[Protein-protein interaction|interact]] with [[RAB7A]].<ref name=pmid11179213 /><ref name=pmid11448994>{{cite journal | vauthors = Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS | title = Human Vam6p promotes lysosome clustering and fusion in vivo | journal = J. Cell Biol. | volume = 154 | issue = 1 | pages = 109–22 | date = July 2001 | pmid = 11448994 | pmc = 2196876 | doi = 10.1083/jcb.200102142 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Bucci C, De Gregorio L, Bruni CB | title = Expression analysis and chromosomal assignment of PRA1 and RILP genes | journal = Biochem. Biophys. Res. Commun. | volume = 286 | issue = 4 | pages = 815–9 | year = 2001 | pmid = 11520070 | doi = 10.1006/bbrc.2001.5466 }}
* {{cite journal | vauthors = Jordens I, Fernandez-Borja M, Marsman M, Dusseljee S, Janssen L, Calafat J, Janssen H, Wubbolts R, Neefjes J | title = The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors | journal = Curr. Biol. | volume = 11 | issue = 21 | pages = 1680–5 | year = 2002 | pmid = 11696325 | doi = 10.1016/S0960-9822(01)00531-0 }}
* {{cite journal | vauthors = Wang T, Hong W | title = Interorganellar Regulation of Lysosome Positioning by the Golgi Apparatus through Rab34 Interaction with Rab-interacting Lysosomal Protein | journal = Mol. Biol. Cell | volume = 13 | issue = 12 | pages = 4317–32 | year = 2003 | pmid = 12475955 | pmc = 138636 | doi = 10.1091/mbc.E02-05-0280 }}
* {{cite journal | vauthors = Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH | title = Refinement of a 400-kb Critical Region Allows Genotypic Differentiation between Isolated Lissencephaly, Miller-Dieker Syndrome, and Other Phenotypes Secondary to Deletions of 17p13.3 | journal = Am. J. Hum. Genet. | volume = 72 | issue = 4 | pages = 918–30 | year = 2003 | pmid = 12621583 | pmc = 1180354 | doi = 10.1086/374320 }}
* {{cite journal | vauthors = Harrison RE, Bucci C, Vieira OV, Schroer TA, Grinstein S | title = Phagosomes Fuse with Late Endosomes and/or Lysosomes by Extension of Membrane Protrusions along Microtubules: Role of Rab7 and RILP | journal = Mol. Cell. Biol. | volume = 23 | issue = 18 | pages = 6494–506 | year = 2003 | pmid = 12944476 | pmc = 193691 | doi = 10.1128/MCB.23.18.6494-6506.2003 }}
* {{cite journal | vauthors = Wang T, Wong KK, Hong W | title = A Unique Region of RILP Distinguishes It from Its Related Proteins in Its Regulation of Lysosomal Morphology and Interaction with Rab7 and Rab34 | journal = Mol. Biol. Cell | volume = 15 | issue = 2 | pages = 815–26 | year = 2004 | pmid = 14668488 | pmc = 329395 | doi = 10.1091/mbc.E03-06-0413 }}
* {{cite journal | vauthors = Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J | title = Large-scale cDNA transfection screening for genes related to cancer development and progression | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 44 | pages = 15724–9 | year = 2004 | pmid = 15498874 | pmc = 524842 | doi = 10.1073/pnas.0404089101 }}
* {{cite journal | vauthors = Wu M, Wang T, Loh E, Hong W, Song H | title = Structural basis for recruitment of RILP by small GTPase Rab7 | journal = EMBO J. | volume = 24 | issue = 8 | pages = 1491–501 | year = 2005 | pmid = 15933719 | pmc = 1142575 | doi = 10.1038/sj.emboj.7600643 }}
* {{cite journal | vauthors = Colucci AM, Campana MC, Bellopede M, Bucci C | title = The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction | journal = Biochem. Biophys. Res. Commun. | volume = 334 | issue = 1 | pages = 128–33 | year = 2005 | pmid = 15996637 | doi = 10.1016/j.bbrc.2005.06.067 }}
* {{cite journal | vauthors = Shimojo M, Hersh LB | title = Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF | journal = J. Neurochem. | volume = 96 | issue = 4 | pages = 1130–8 | year = 2006 | pmid = 16417580 | doi = 10.1111/j.1471-4159.2005.03608.x }}
* {{cite journal | vauthors = Marsman M, Jordens I, Rocha N, Kuijl C, Janssen L, Neefjes J | title = A splice variant of RILP induces lysosomal clustering independent of dynein recruitment | journal = Biochem. Biophys. Res. Commun. | volume = 344 | issue = 3 | pages = 747–56 | year = 2006 | pmid = 16631113 | doi = 10.1016/j.bbrc.2006.03.178 }}
* {{cite journal | vauthors = Progida C, Spinosa MR, De Luca A, Bucci C | title = RILP interacts with the VPS22 component of the ESCRT-II complex | journal = Biochem. Biophys. Res. Commun. | volume = 347 | issue = 4 | pages = 1074–9 | year = 2006 | pmid = 16857164 | doi = 10.1016/j.bbrc.2006.07.007 }}
{{Refend}}
 
{{PDB Gallery|geneid=83547}}
 
 
{{Gene-17-stub}}

Latest revision as of 09:13, 10 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rab-interacting lysosomal protein is a protein that in humans is encoded by the RILP gene.[1][2]

Function

RILP, along with the GTPase RAB7 (MIM 602298), controls late endocytic transport.[supplied by OMIM][2]

Interactions

RILP (gene) has been shown to interact with RAB7A.[1][3]

References

  1. ↑ 1.0 1.1 Cantalupo G, Alifano P, Roberti V, Bruni CB, Bucci C (February 2001). "Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes". EMBO J. 20 (4): 683–93. doi:10.1093/emboj/20.4.683. PMC 145419. PMID 11179213.
  2. ↑ 2.0 2.1 "Entrez Gene: RILP Rab interacting lysosomal protein".
  3. ↑ Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS (July 2001). "Human Vam6p promotes lysosome clustering and fusion in vivo". J. Cell Biol. 154 (1): 109–22. doi:10.1083/jcb.200102142. PMC 2196876. PMID 11448994.

Further reading


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