ATXN2L: Difference between revisions

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{{Infobox_gene}}
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'''Ataxin-2-like protein''' is a [[protein]] that in humans is encoded by the ''ATXN2L'' [[gene]].<ref name="pmid11784712">{{cite journal | vauthors = Meunier C, Bordereaux D, Porteu F, Gisselbrecht S, Chretien S, Courtois G | title = Cloning and characterization of a family of proteins associated with Mpl | journal = J Biol Chem | volume = 277 | issue = 11 | pages = 9139–47 |date=Mar 2002 | pmid = 11784712 | pmc =  | doi = 10.1074/jbc.M105970200 }}</ref><ref name="pmid14769358">{{cite journal | vauthors = Figueroa KP, Pulst SM | title = Identification and expression of the gene for human ataxin-2-related protein on chromosome 16 | journal = Exp Neurol | volume = 184 | issue = 2 | pages = 669–78 |date=Feb 2004 | pmid = 14769358 | pmc =  | doi = 10.1016/S0014-4886(03)00287-5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATXN2L ataxin 2-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11273| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ataxin 2-like
| HGNCid = 31326
| Symbol = ATXN2L
| AltSymbols =; A2D; A2LG; A2LP; A2RP
| OMIM = 607931
| ECnumber =
| Homologene = 16513
| MGIid = 2446242
  | GeneAtlas_image1 = PBB_GE_ATXN2L_201806_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATXN2L_207798_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}  
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11273
    | Hs_Ensembl = ENSG00000168488
    | Hs_RefseqProtein = XP_001127543
    | Hs_RefseqmRNA = XM_001127543
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 28741857
    | Hs_GenLoc_end = 28756057
    | Hs_Uniprot = Q8WWM7
    | Mm_EntrezGene = 233871
    | Mm_Ensembl = ENSMUSG00000032637
    | Mm_RefseqmRNA = NM_183020
    | Mm_RefseqProtein = NP_898841
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 126282856
    | Mm_GenLoc_end = 126294450
    | Mm_Uniprot = Q3TGG2
  }}
}}
'''Ataxin 2-like''', also known as '''ATXN2L''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATXN2L ataxin 2-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11273| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ATXN2L ataxin 2-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11273| accessdate = }}</ref>
| summary_text = This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ATXN2L ataxin 2-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11273| accessdate = }}</ref>
}}
}}
==Interactions==
ATXN2L has been shown to [[Protein-protein interaction|interact]] with [[Myeloproliferative leukemia virus oncogene]].<ref name=pmid11784712 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ATXN2L}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
*{{cite journal  | author=Pulst SM, Nechiporuk A, Nechiporuk T, ''et al.'' |title=Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. |journal=Nat. Genet. |volume=14 |issue= 3 |pages= 269-76 |year= 1996 |pmid= 8896555 |doi= 10.1038/ng1196-269 }}
*{{cite journal  | vauthors=Pulst SM, Nechiporuk A, Nechiporuk T |title=Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. |journal=Nat. Genet. |volume=14 |issue= 3 |pages= 269–76 |year= 1996 |pmid= 8896555 |doi= 10.1038/ng1196-269 |display-authors=etal}}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |display-authors=etal}}
*{{cite journal  | author=Meunier C, Bordereaux D, Porteu F, ''et al.'' |title=Cloning and characterization of a family of proteins associated with Mpl. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9139-47 |year= 2002 |pmid= 11784712 |doi= 10.1074/jbc.M105970200 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Brill LM, Salomon AR, Ficarro SB |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |display-authors=etal}}
*{{cite journal | author=Figueroa KP, Pulst SM |title=Identification and expression of the gene for human ataxin-2-related protein on chromosome 16. |journal=Exp. Neurol. |volume=184 |issue= 2 |pages= 669-78 |year= 2004 |pmid= 14769358 |doi= 10.1016/S0014-4886(03)00287-5 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}}
*{{cite journal  | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | vauthors=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119–26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}}
*{{cite journal  | author=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119-26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }}
*{{cite journal  | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | vauthors=Nonhoff U, Ralser M, Welzel F |title=Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules. |journal=Mol. Biol. Cell |volume=18 |issue= 4 |pages= 1385–96 |year= 2007 |pmid= 17392519 |doi= 10.1091/mbc.E06-12-1120 | pmc=1838996 |display-authors=etal}}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Nonhoff U, Ralser M, Welzel F, ''et al.'' |title=Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules. |journal=Mol. Biol. Cell |volume=18 |issue= 4 |pages= 1385-96 |year= 2007 |pmid= 17392519 |doi= 10.1091/mbc.E06-12-1120 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-16-stub}}

Latest revision as of 18:29, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ataxin-2-like protein is a protein that in humans is encoded by the ATXN2L gene.[1][2][3]

This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.[3]

Interactions

ATXN2L has been shown to interact with Myeloproliferative leukemia virus oncogene.[1]

References

  1. ↑ 1.0 1.1 Meunier C, Bordereaux D, Porteu F, Gisselbrecht S, Chretien S, Courtois G (Mar 2002). "Cloning and characterization of a family of proteins associated with Mpl". J Biol Chem. 277 (11): 9139–47. doi:10.1074/jbc.M105970200. PMID 11784712.
  2. ↑ Figueroa KP, Pulst SM (Feb 2004). "Identification and expression of the gene for human ataxin-2-related protein on chromosome 16". Exp Neurol. 184 (2): 669–78. doi:10.1016/S0014-4886(03)00287-5. PMID 14769358.
  3. ↑ 3.0 3.1 "Entrez Gene: ATXN2L ataxin 2-like".

External links

Further reading



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