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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''ADP-ribosylation factor-binding protein GGA2''' is a [[protein]] that in humans is encoded by the ''GGA2'' [[gene]].<ref name="pmid10747088">{{cite journal | vauthors = Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS | title = A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome | journal = The Journal of Cell Biology | volume = 149 | issue = 1 | pages = 67–80 | date = Apr 2000 | pmid = 10747088 | pmc = 2175106 | doi = 10.1083/jcb.149.1.67 }}</ref><ref name="pmid10749927">{{cite journal | vauthors = Boman AL, Zhang CJ, Zhu X, Kahn RA | title = A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi | journal = Molecular Biology of the Cell | volume = 11 | issue = 4 | pages = 1241–55 | date = Apr 2000 | pmid = 10749927 | pmc = 14844 | doi = 10.1091/mbc.11.4.1241 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23062| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_GGA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mhq.
| PDB = {{PDB2|1mhq}}
| Name = Golgi associated, gamma adaptin ear containing, ARF binding protein 2
| HGNCid = 16064
| Symbol = GGA2
| AltSymbols =; FLJ20966; KIAA1080; VEAR
| OMIM = 606005
| ECnumber = 
| Homologene = 22860
| MGIid = 1921355
| GeneAtlas_image1 = PBB_GE_GGA2_208913_at_tn.png
| GeneAtlas_image2 = PBB_GE_GGA2_208914_at_tn.png
| GeneAtlas_image3 = PBB_GE_GGA2_208915_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030306 |text = ADP-ribosylation factor binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005802 |text = trans-Golgi network}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030130 |text = clathrin coat of trans-Golgi network vesicle}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23062
    | Hs_Ensembl = ENSG00000103365
    | Hs_RefseqProtein = NP_055859
    | Hs_RefseqmRNA = NM_015044
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 23383145
    | Hs_GenLoc_end = 23429309
    | Hs_Uniprot = Q9UJY4
    | Mm_EntrezGene = 74105
    | Mm_Ensembl = ENSMUSG00000030872
    | Mm_RefseqmRNA = NM_028758
    | Mm_RefseqProtein = NP_083034
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 121777870
    | Mm_GenLoc_end = 121812315
    | Mm_Uniprot = Q3TVV9
  }}
}}
'''Golgi associated, gamma adaptin ear containing, ARF binding protein 2''', also known as '''GGA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23062| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.<ref name="entrez">{{cite web | title = Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23062| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
GGA2 has been shown to [[Protein-protein interaction|interact]] with [[RABEP1]],<ref name=pmid12505986>{{cite journal | vauthors = Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS | title = Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex | journal = The EMBO Journal | volume = 22 | issue = 1 | pages = 78–88 | date = Jan 2003 | pmid = 12505986 | pmc = 140067 | doi = 10.1093/emboj/cdg015 }}</ref> [[Sortilin 1]],<ref name=pmid11331584>{{cite journal | vauthors = Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen CM | title = The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein | journal = The EMBO Journal | volume = 20 | issue = 9 | pages = 2180–90 | date = May 2001 | pmid = 11331584 | pmc = 125444 | doi = 10.1093/emboj/20.9.2180 }}</ref><ref name=pmid11821067>{{cite journal | vauthors = Jacobsen L, Madsen P, Nielsen MS, Geraerts WP, Gliemann J, Smit AB, Petersen CM | title = The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding | journal = FEBS Letters | volume = 511 | issue = 1-3 | pages = 155–8 | date = Jan 2002 | pmid = 11821067 | doi = 10.1016/S0014-5793(01)03299-9 }}</ref> [[BACE2]]<ref name=pmid12135764>{{cite journal | vauthors = He X, Chang WP, Koelsch G, Tang J | title = Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2 | journal = FEBS Letters | volume = 524 | issue = 1-3 | pages = 183–7 | date = Jul 2002 | pmid = 12135764 | doi = 10.1016/S0014-5793(02)03052-1 }}</ref> and [[CLINT1]].<ref name=pmid12213833>{{cite journal | vauthors = Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS | title = Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics | journal = The Journal of Cell Biology | volume = 158 | issue = 5 | pages = 855–62 | date = Sep 2002 | pmid = 12213833 | pmc = 2173151 | doi = 10.1083/jcb.200205078 }}</ref><ref name=pmid12429846>{{cite journal | vauthors = Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ | title = Clint: a novel clathrin-binding ENTH-domain protein at the Golgi | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4060–73 | date = Nov 2002 | pmid = 12429846 | pmc = 133614 | doi = 10.1091/mbc.E02-03-0171 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
| citations =
* {{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 3 | pages = 197–205 | date = Jun 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD | title = Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q | journal = Genomics | volume = 60 | issue = 3 | pages = 295–308 | date = Sep 1999 | pmid = 10493829 | doi = 10.1006/geno.1999.5927 }}
*{{cite journal | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi= }}
* {{cite journal | vauthors = Poussu A, Lohi O, Lehto VP | title = Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains | journal = The Journal of Biological Chemistry | volume = 275 | issue = 10 | pages = 7176–83 | date = Mar 2000 | pmid = 10702286 | doi = 10.1074/jbc.275.10.7176 }}
*{{cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, ''et al.'' |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295-308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
* {{cite journal | vauthors = Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS | title = GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex | journal = The Journal of Cell Biology | volume = 149 | issue = 1 | pages = 81–94 | date = Apr 2000 | pmid = 10747089 | pmc = 2175099 | doi = 10.1083/jcb.149.1.81 }}
*{{cite journal | author=Poussu A, Lohi O, Lehto VP |title=Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7176-83 |year= 2000 |pmid= 10702286 |doi= }}
* {{cite journal | vauthors = Takatsu H, Yoshino K, Nakayama K | title = Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin | journal = Biochemical and Biophysical Research Communications | volume = 271 | issue = 3 | pages = 719–25 | date = May 2000 | pmid = 10814529 | doi = 10.1006/bbrc.2000.2700 }}
*{{cite journal | author=Hirst J, Lui WW, Bright NA, ''et al.'' |title=A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 67-80 |year= 2000 |pmid= 10747088 |doi= }}
* {{cite journal | vauthors = Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS | title = The GGAs promote ARF-dependent recruitment of clathrin to the TGN | journal = Cell | volume = 105 | issue = 1 | pages = 93–102 | date = Apr 2001 | pmid = 11301005 | doi = 10.1016/S0092-8674(01)00299-9 }}
*{{cite journal | author=Dell'Angelica EC, Puertollano R, Mullins C, ''et al.'' |title=GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 81-94 |year= 2000 |pmid= 10747089 |doi= }}
* {{cite journal | vauthors = Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen CM | title = The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein | journal = The EMBO Journal | volume = 20 | issue = 9 | pages = 2180–90 | date = May 2001 | pmid = 11331584 | pmc = 125444 | doi = 10.1093/emboj/20.9.2180 }}
*{{cite journal | author=Boman AL, Zhang C, Zhu X, Kahn RA |title=A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi. |journal=Mol. Biol. Cell |volume=11 |issue= 4 |pages= 1241-55 |year= 2000 |pmid= 10749927 |doi= }}
* {{cite journal | vauthors = Puertollano R, Aguilar RC, Gorshkova I, Crouch RJ, Bonifacino JS | title = Sorting of mannose 6-phosphate receptors mediated by the GGAs | journal = Science | volume = 292 | issue = 5522 | pages = 1712–6 | date = Jun 2001 | pmid = 11387475 | doi = 10.1126/science.1060750 }}
*{{cite journal | author=Takatsu H, Yoshino K, Nakayama K |title=Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin. |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 3 |pages= 719-25 |year= 2000 |pmid= 10814529 |doi= 10.1006/bbrc.2000.2700 }}
* {{cite journal | vauthors = Zhu Y, Doray B, Poussu A, Lehto VP, Kornfeld S | title = Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor | journal = Science | volume = 292 | issue = 5522 | pages = 1716–8 | date = Jun 2001 | pmid = 11387476 | doi = 10.1126/science.1060896 }}
*{{cite journal | author=Puertollano R, Randazzo PA, Presley JF, ''et al.'' |title=The GGAs promote ARF-dependent recruitment of clathrin to the TGN. |journal=Cell |volume=105 |issue= 1 |pages= 93-102 |year= 2001 |pmid= 11301005 |doi= }}
* {{cite journal | vauthors = Takatsu H, Katoh Y, Shiba Y, Nakayama K | title = Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains | journal = The Journal of Biological Chemistry | volume = 276 | issue = 30 | pages = 28541–5 | date = Jul 2001 | pmid = 11390366 | doi = 10.1074/jbc.C100218200 }}
*{{cite journal | author=Nielsen MS, Madsen P, Christensen EI, ''et al.'' |title=The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2180-90 |year= 2001 |pmid= 11331584 |doi= 10.1093/emboj/20.9.2180 }}
* {{cite journal | vauthors = Jacobsen L, Madsen P, Nielsen MS, Geraerts WP, Gliemann J, Smit AB, Petersen CM | title = The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding | journal = FEBS Letters | volume = 511 | issue = 1-3 | pages = 155–8 | date = Jan 2002 | pmid = 11821067 | doi = 10.1016/S0014-5793(01)03299-9 }}
*{{cite journal | author=Puertollano R, Aguilar RC, Gorshkova I, ''et al.'' |title=Sorting of mannose 6-phosphate receptors mediated by the GGAs. |journal=Science |volume=292 |issue= 5522 |pages= 1712-6 |year= 2001 |pmid= 11387475 |doi= 10.1126/science.1060750 }}
* {{cite journal | vauthors = Doray B, Bruns K, Ghosh P, Kornfeld S | title = Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins | journal = The Journal of Biological Chemistry | volume = 277 | issue = 21 | pages = 18477–82 | date = May 2002 | pmid = 11886874 | doi = 10.1074/jbc.M201879200 }}
*{{cite journal | author=Zhu Y, Doray B, Poussu A, ''et al.'' |title=Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor. |journal=Science |volume=292 |issue= 5522 |pages= 1716-8 |year= 2001 |pmid= 11387476 |doi= 10.1126/science.1060896 }}
* {{cite journal | vauthors = Takatsu H, Yoshino K, Toda K, Nakayama K | title = GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors | journal = The Biochemical Journal | volume = 365 | issue = Pt 2 | pages = 369–78 | date = Jul 2002 | pmid = 11950392 | pmc = 1222692 | doi = 10.1042/BJ20020428 }}
*{{cite journal | author=Takatsu H, Katoh Y, Shiba Y, Nakayama K |title=Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28541-5 |year= 2001 |pmid= 11390366 |doi= 10.1074/jbc.C100218200 }}
* {{cite journal | vauthors = He X, Chang WP, Koelsch G, Tang J | title = Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2 | journal = FEBS Letters | volume = 524 | issue = 1-3 | pages = 183–7 | date = Jul 2002 | pmid = 12135764 | doi = 10.1016/S0014-5793(02)03052-1 }}
*{{cite journal | author=Jacobsen L, Madsen P, Nielsen MS, ''et al.'' |title=The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. |journal=FEBS Lett. |volume=511 |issue= 1-3 |pages= 155-8 |year= 2002 |pmid= 11821067 |doi= }}
* {{cite journal | vauthors = Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS | title = Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics | journal = The Journal of Cell Biology | volume = 158 | issue = 5 | pages = 855–62 | date = Sep 2002 | pmid = 12213833 | pmc = 2173151 | doi = 10.1083/jcb.200205078 }}
*{{cite journal | author=Doray B, Bruns K, Ghosh P, Kornfeld S |title=Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18477-82 |year= 2002 |pmid= 11886874 |doi= 10.1074/jbc.M201879200 }}
* {{cite journal | vauthors = Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ | title = Clint: a novel clathrin-binding ENTH-domain protein at the Golgi | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4060–73 | date = Nov 2002 | pmid = 12429846 | pmc = 133614 | doi = 10.1091/mbc.E02-03-0171 }}
*{{cite journal | author=Takatsu H, Yoshino K, Toda K, Nakayama K |title=GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. |journal=Biochem. J. |volume=365 |issue= Pt 2 |pages= 369-78 |year= 2002 |pmid= 11950392 |doi= 10.1042/BJ20020428 }}
*{{cite journal | author=He X, Chang WP, Koelsch G, Tang J |title=Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2. |journal=FEBS Lett. |volume=524 |issue= 1-3 |pages= 183-7 |year= 2002 |pmid= 12135764 |doi= }}
*{{cite journal | author=Wasiak S, Legendre-Guillemin V, Puertollano R, ''et al.'' |title=Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. |journal=J. Cell Biol. |volume=158 |issue= 5 |pages= 855-62 |year= 2002 |pmid= 12213833 |doi= 10.1083/jcb.200205078 }}
*{{cite journal  | author=Kalthoff C, Groos S, Kohl R, ''et al.'' |title=Clint: a novel clathrin-binding ENTH-domain protein at the Golgi. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4060-73 |year= 2003 |pmid= 12429846 |doi= 10.1091/mbc.E02-03-0171 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=23062}}
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Revision as of 08:44, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene.[1][2][3]

Function

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.[3]

Interactions

GGA2 has been shown to interact with RABEP1,[4] Sortilin 1,[5][6] BACE2[7] and CLINT1.[8][9]

References

  1. ↑ Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (Apr 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
  2. ↑ Boman AL, Zhang CJ, Zhu X, Kahn RA (Apr 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Molecular Biology of the Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC 14844. PMID 10749927.
  3. ↑ 3.0 3.1 "Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2".
  4. ↑ Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
  5. ↑ Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen CM (May 2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein". The EMBO Journal. 20 (9): 2180–90. doi:10.1093/emboj/20.9.2180. PMC 125444. PMID 11331584.
  6. ↑ Jacobsen L, Madsen P, Nielsen MS, Geraerts WP, Gliemann J, Smit AB, Petersen CM (Jan 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Letters. 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. PMID 11821067.
  7. ↑ He X, Chang WP, Koelsch G, Tang J (Jul 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Letters. 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. PMID 12135764.
  8. ↑ Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (Sep 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". The Journal of Cell Biology. 158 (5): 855–62. doi:10.1083/jcb.200205078. PMC 2173151. PMID 12213833.
  9. ↑ Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Molecular Biology of the Cell. 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMC 133614. PMID 12429846.

Further reading

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