DDX11: Difference between revisions

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{{Infobox_gene}}
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'''Probable ATP-dependent RNA helicase DDX11''' is an [[enzyme]] that in humans is encoded by the ''DDX11'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1663| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)
| HGNCid = 2736
| Symbol = DDX11
| AltSymbols =; CHL1; CHLR1; KRG2; MGC133249; MGC9335
| OMIM = 601150
| ECnumber = 
| Homologene = 68973
| MGIid = 2443590
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004003 |text = ATP-dependent DNA helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016818 |text = hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0000070 |text = mitotic sister chromatid segregation}} {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000084 |text = S phase of mitotic cell cycle}} {{GNF_GO|id=GO:0000086 |text = G2/M transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1663
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001124814
    | Hs_RefseqmRNA = XM_001124814
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 320209
    | Mm_Ensembl = ENSMUSG00000035842
    | Mm_RefseqmRNA = NM_001003919
    | Mm_RefseqProtein = NP_001003919
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 66023114
    | Mm_GenLoc_end = 66051251
    | Mm_Uniprot = Q80YC3
  }}
}}
'''DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)''', also known as '''DDX11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1663| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1663| accessdate = }}</ref>
| summary_text = [[DEAD box]] proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative [[RNA helicase]]s. They are implicated in a number of cellular processes involving alteration of [[RNA]] secondary structure such as [[Translation (biology)|translation]] initiation, nuclear and mitochondrial splicing, and [[ribosome]] and [[spliceosome]] assembly.  
Based on their distribution patterns, some members of this family are believed to be involved in [[embryogenesis]], [[spermatogenesis]], and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both [[ATPase]] and DNA helicase activities. This gene is a homolog of the yeast [[CHL1]] gene, and may function to maintain chromosome transmission fidelity and genome stability. [[Alternative splicing]] results in multiple transcript variants encoding distinct [[isoform]]s.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Baens M, Aerssens J, van Zand K, ''et al.'' |title=Isolation and regional assignment of human chromosome 12p cDNAs. |journal=Genomics |volume=29 |issue= 1 |pages= 44-52 |year= 1996 |pmid= 8530100 |doi= 10.1006/geno.1995.1213 }}
*{{cite journal  | vauthors=Baens M, Aerssens J, van Zand K |title=Isolation and regional assignment of human chromosome 12p cDNAs. |journal=Genomics |volume=29 |issue= 1 |pages= 44–52 |year= 1996 |pmid= 8530100 |doi= 10.1006/geno.1995.1213 |display-authors=etal}}
*{{cite journal  | author=Frank S, Werner S |title=The human homologue of the yeast CHL1 gene is a novel keratinocyte growth factor-regulated gene. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24337-40 |year= 1996 |pmid= 8798685 |doi=  }}
*{{cite journal  | vauthors=Frank S, Werner S |title=The human homologue of the yeast CHL1 gene is a novel keratinocyte growth factor-regulated gene. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24337–40 |year= 1996 |pmid= 8798685 |doi=10.1074/jbc.271.40.24337 }}
*{{cite journal  | author=Amann J, Valentine M, Kidd VJ, Lahti JM |title=Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA. |journal=Genomics |volume=32 |issue= 2 |pages= 260-5 |year= 1997 |pmid= 8833153 |doi=  }}
*{{cite journal  | vauthors=Amann J, Valentine M, Kidd VJ, Lahti JM |title=Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA. |journal=Genomics |volume=32 |issue= 2 |pages= 260–5 |year= 1997 |pmid= 8833153 |doi=10.1006/geno.1996.0113 }}
*{{cite journal  | author=Amann J, Kidd VJ, Lahti JM |title=Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1. |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3823-32 |year= 1997 |pmid= 9013641 |doi=  }}
*{{cite journal  | vauthors=Amann J, Kidd VJ, Lahti JM |title=Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1. |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3823–32 |year= 1997 |pmid= 9013641 |doi=10.1074/jbc.272.6.3823 }}
*{{cite journal  | author=Hirota Y, Lahti JM |title=Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase. |journal=Nucleic Acids Res. |volume=28 |issue= 4 |pages= 917-24 |year= 2000 |pmid= 10648783 |doi=  }}
*{{cite journal  | vauthors=Hirota Y, Lahti JM |title=Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase. |journal=Nucleic Acids Res. |volume=28 |issue= 4 |pages= 917–24 |year= 2000 |pmid= 10648783 |doi=10.1093/nar/28.4.917  | pmc=102573 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Vasa-Nicotera M, Brouilette S, Mangino M, ''et al.'' |title=Mapping of a major locus that determines telomere length in humans. |journal=Am. J. Hum. Genet. |volume=76 |issue= 1 |pages= 147-51 |year= 2005 |pmid= 15520935 |doi= 10.1086/426734 }}
*{{cite journal  | vauthors=Vasa-Nicotera M, Brouilette S, Mangino M |title=Mapping of a major locus that determines telomere length in humans. |journal=Am. J. Hum. Genet. |volume=76 |issue= 1 |pages= 147–51 |year= 2005 |pmid= 15520935 |doi= 10.1086/426734 | pmc=1196417 |display-authors=etal}}
*{{cite journal  | author=Parish JL, Rosa J, Wang X, ''et al.'' |title=The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. |journal=J. Cell. Sci. |volume=119 |issue= Pt 23 |pages= 4857-65 |year= 2007 |pmid= 17105772 |doi= 10.1242/jcs.03262 }}
*{{cite journal  | vauthors=Parish JL, Rosa J, Wang X |title=The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. |journal=J. Cell Sci. |volume=119 |issue= Pt 23 |pages= 4857–65 |year= 2007 |pmid= 17105772 |doi= 10.1242/jcs.03262 |display-authors=etal}}
*{{cite journal  | author=Parish JL, Bean AM, Park RB, Androphy EJ |title=ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance. |journal=Mol. Cell |volume=24 |issue= 6 |pages= 867-76 |year= 2007 |pmid= 17189189 |doi= 10.1016/j.molcel.2006.11.005 }}
*{{cite journal  | vauthors=Parish JL, Bean AM, Park RB, Androphy EJ |title=ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance. |journal=Mol. Cell |volume=24 |issue= 6 |pages= 867–76 |year= 2007 |pmid= 17189189 |doi= 10.1016/j.molcel.2006.11.005 }}
}}
}}
{{refend}}
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Latest revision as of 19:43, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable ATP-dependent RNA helicase DDX11 is an enzyme that in humans is encoded by the DDX11 gene.[1]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)".

Further reading



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