MED21: Difference between revisions

VALUE_ERROR (nil)
Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

VisualWikitext

Latest revision as of 06:20, 4 September 2017

Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.^[1]^[2]

Interactions

MED21 has been shown to interact with:

References

↑ Chao DM, Gadbois EL, Murray PJ, Anderson SF, Sonu MS, Parvin JD, Young RA (Apr 1996). "A mammalian SRB protein associated with an RNA polymerase II holoenzyme". Nature. 380 (6569): 82–5. doi:10.1038/380082a0. PMID 8598913.
↑ "Entrez Gene: SURB7 SRB7 suppressor of RNA polymerase B homolog (yeast)".
↑ ^3.0 ^3.1 ^3.2 ^3.3 Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
↑ ^4.0 ^4.1 Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. PMC 109120. PMID 9710619.
↑ ^5.0 ^5.1 ^5.2 Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (Oct 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. PMC 232452. PMID 9315662.
↑ Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi:10.1016/s1097-2765(00)80463-3. PMID 10198638.
↑ Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.
↑ Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D (Aug 1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell. 2 (2): 213–22. doi:10.1016/s1097-2765(00)80131-8. PMID 9734358.

Zheng XM, Black D, Chambon P, Egly JM (1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3". Nature. 344 (6266): 556–9. doi:10.1038/344556a0. PMID 2320128.
Maldonado E, Shiekhattar R, Sheldon M, Cho H, Drapkin R, Rickert P, Lees E, Anderson CW, Linn S, Reinberg D (1996). "A human RNA polymerase II complex associated with SRB and DNA-repair proteins". Nature. 381 (6577): 86–9. doi:10.1038/381086a0. PMID 8609996.
Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028. PMID 9121429.
Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
Pan G, Aso T, Greenblatt J (1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". J. Biol. Chem. 272 (39): 24563–71. doi:10.1074/jbc.272.39.24563. PMID 9305922.
Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. PMC 109120. PMID 9710619.
Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell. 2 (2): 213–22. doi:10.1016/S1097-2765(00)80131-8. PMID 9734358.
Garriga J, Peng J, Parreño M, Price DH, Henderson EE, Graña X (1999). "Upregulation of cyclin T1/CDK9 complexes during T cell activation". Oncogene. 17 (24): 3093–102. doi:10.1038/sj.onc.1202548. PMID 9872325.
Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J, Roeder RG (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell. 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
Ramanathan Y, Rajpara SM, Reza SM, Lees E, Shuman S, Mathews MB, Pe'ery T (2001). "Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences". J. Biol. Chem. 276 (14): 10913–20. doi:10.1074/jbc.M010975200. PMID 11278802.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature. 417 (6888): 563–7. doi:10.1038/417563a. PMID 12037571.
Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Wallberg AE, Yamamura S, Malik S, Spiegelman BM, Roeder RG (2004). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. 12 (5): 1137–49. doi:10.1016/S1097-2765(03)00391-5. PMID 14636573.
Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Nevado J, Tenbaum SP, Aranda A (2005). "hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor". Mol. Cell. Endocrinol. 222 (1–2): 41–51. doi:10.1016/j.mce.2004.05.003. PMID 15249124.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[pmid8598913-1] Chao DM, Gadbois EL, Murray PJ, Anderson SF, Sonu MS, Parvin JD, Young RA (Apr 1996). "A mammalian SRB protein associated with an RNA polymerase II holoenzyme". Nature. 380 (6569): 82–5. doi:10.1038/380082a0. PMID 8598913.

[entrez-2] "Entrez Gene: SURB7 SRB7 suppressor of RNA polymerase B homolog (yeast)".

[pmid9159119-3] 3.0 ^3.1 ^3.2 ^3.3 Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.

[pmid9710619-4] 4.0 ^4.1 Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. PMC 109120. PMID 9710619.

[pmid9315662-5] 5.0 ^5.1 ^5.2 Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (Oct 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. PMC 232452. PMID 9315662.

[pmid10198638-6] Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi:10.1016/s1097-2765(00)80463-3. PMID 10198638.

[pmid11867769-7] Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.

[pmid9734358-8] Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D (Aug 1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell. 2 (2): 213–22. doi:10.1016/s1097-2765(00)80131-8. PMID 9734358.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Mediator of RNA polymerase II transcription subunit 21''' is an [[enzyme]] that in humans is encoded by the ''MED21'' [[gene]].<ref name="pmid8598913">{{cite journal |vauthors=Chao DM, Gadbois EL, Murray PJ, Anderson SF, Sonu MS, Parvin JD, Young RA | title = A mammalian SRB protein associated with an RNA polymerase II holoenzyme | journal = Nature | volume = 380 | issue = 6569 | pages = 82–5 | date = Apr 1996 | pmid = 8598913 | pmc =  | doi = 10.1038/380082a0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SURB7 SRB7 suppressor of RNA polymerase B homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9412| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+==Interactions==
-{{GNF_Protein_box
+MED21 has been shown to [[Protein-protein interaction|interact]] with:
- | image =
+* [[BRCA1]],<ref name = pmid9159119>{{cite journal |vauthors=Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD | title = BRCA1 is a component of the RNA polymerase II holoenzyme | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 11 | pages = 5605–10 | date = May 1997 | pmid = 9159119 | pmc = 20825 | doi =  10.1073/pnas.94.11.5605}}</ref>
- | image_source =
+* [[Cyclin-dependent kinase 8|CDK8]],<ref name = pmid9710619>{{cite journal |vauthors=Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D | title = A human RNA polymerase II complex containing factors that modify chromatin structure | journal = Mol. Cell. Biol. | volume = 18 | issue = 9 | pages = 5355–63 | date = Sep 1998 | pmid = 9710619 | pmc = 109120 | doi =  }}</ref><ref name = pmid9315662>{{cite journal |vauthors=Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA | title = CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription | journal = Mol. Cell. Biol. | volume = 17 | issue = 10 | pages = 6029–39 | date = Oct 1997 | pmid = 9315662 | pmc = 232452 | doi =  }}</ref><ref name = pmid10198638>{{cite journal |vauthors=Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Mol. Cell | volume = 3 | issue = 3 | pages = 361–70 | date = Mar 1999 | pmid = 10198638 | doi =  10.1016/s1097-2765(00)80463-3}}</ref><ref name = pmid11867769>{{cite journal |vauthors=Kang YK, Guermah M, Yuan CX, Roeder RG | title = The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 2642–7 | date = Mar 2002 | pmid = 11867769 | pmc = 122401 | doi = 10.1073/pnas.261715899 }}</ref>
- | PDB =
+* [[GTF2F1]],<ref name = pmid9159119/><ref name = pmid9315662/>
- | Name = SRB7 suppressor of RNA polymerase B homolog (yeast)
+* [[GTF2H4]],<ref name = pmid9159119/>
- | HGNCid = 11473
+* [[MED6]],<ref name = pmid9734358>{{cite journal |vauthors=Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D | title = NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription | journal = Mol. Cell | volume = 2 | issue = 2 | pages = 213–22 | date = Aug 1998 | pmid = 9734358 | doi =  10.1016/s1097-2765(00)80131-8}}</ref>  and
- | Symbol = SURB7
+* [[POLR2A]].<ref name = pmid9159119/><ref name = pmid9710619/><ref name = pmid9315662/>
- | AltSymbols =; MED21; SRB7
- | OMIM = 603800
- | ECnumber =
- | Homologene = 3148
- | MGIid = 1347064
- | GeneAtlas_image1 = PBB_GE_SURB7_209362_at_tn.png
- | GeneAtlas_image2 = PBB_GE_SURB7_209363_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003899 |text = DNA-directed RNA polymerase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0000119 |text = mediator complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005665 |text = DNA-directed RNA polymerase II, core complex}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 9412
-    | Hs_Ensembl = ENSG00000152944
-    | Hs_RefseqProtein = NP_004255
-    | Hs_RefseqmRNA = NM_004264
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 27066746
-    | Hs_GenLoc_end = 27073947
-    | Hs_Uniprot = Q13503
-    | Mm_EntrezGene = 108098
-    | Mm_Ensembl = ENSMUSG00000030291
-    | Mm_RefseqmRNA = NM_025315
-    | Mm_RefseqProtein = NP_079591
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 6
-    | Mm_GenLoc_start = 146599749
-    | Mm_GenLoc_end = 146607770
-    | Mm_Uniprot =
-  }}
-}}
-'''SRB7 suppressor of RNA polymerase B homolog (yeast)''', also known as '''SURB7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SURB7 SRB7 suppressor of RNA polymerase B homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9412| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+==References==
-{{PBB_Summary
+{{Reflist}}
-| section_title =
+{{Clear}}
-| summary_text =
-}}
-==References==
-{{reflist|2}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal |vauthors=Zheng XM, Black D, Chambon P, Egly JM | title = Sequencing and expression of complementary DNA for the general transcription factor BTF3. | journal = Nature | volume = 344 | issue = 6266 | pages = 556–9 | year = 1990 | pmid = 2320128 | doi = 10.1038/344556a0 }}
-| citations =
+*{{cite journal |vauthors=Maldonado E, Shiekhattar R, Sheldon M, Cho H, Drapkin R, Rickert P, Lees E, Anderson CW, Linn S, Reinberg D | title = A human RNA polymerase II complex associated with SRB and DNA-repair proteins. | journal = Nature | volume = 381 | issue = 6577 | pages = 86–9 | year = 1996 | pmid = 8609996 | doi = 10.1038/381086a0 }}
-*{{cite journal  | author=Zheng XM, Black D, Chambon P, Egly JM |title=Sequencing and expression of complementary DNA for the general transcription factor BTF3. |journal=Nature |volume=344 |issue= 6266 |pages= 556-9 |year= 1990 |pmid= 2320128 |doi= 10.1038/344556a0 }}
+*{{cite journal |vauthors=Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM | title = The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 1817–23 | year = 1997 | pmid = 9121429 | pmc = 232028 | doi =  }}
-*{{cite journal  | author=Chao DM, Gadbois EL, Murray PJ, ''et al.'' |title=A mammalian SRB protein associated with an RNA polymerase II holoenzyme. |journal=Nature |volume=380 |issue= 6569 |pages= 82-5 |year= 1996 |pmid= 8598913 |doi= 10.1038/380082a0 }}
+*{{cite journal |vauthors=Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD | title = BRCA1 is a component of the RNA polymerase II holoenzyme. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 11 | pages = 5605–10 | year = 1997 | pmid = 9159119 | pmc = 20825 | doi = 10.1073/pnas.94.11.5605 }}
-*{{cite journal  | author=Maldonado E, Shiekhattar R, Sheldon M, ''et al.'' |title=A human RNA polymerase II complex associated with SRB and DNA-repair proteins. |journal=Nature |volume=381 |issue= 6577 |pages= 86-9 |year= 1996 |pmid= 8609996 |doi= 10.1038/381086a0 }}
+*{{cite journal |vauthors=Pan G, Aso T, Greenblatt J | title = Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators. | journal = J. Biol. Chem. | volume = 272 | issue = 39 | pages = 24563–71 | year = 1997 | pmid = 9305922 | doi = 10.1074/jbc.272.39.24563 }}
-*{{cite journal  | author=Cujec TP, Cho H, Maldonado E, ''et al.'' |title=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1817-23 |year= 1997 |pmid= 9121429 |doi=  }}
+*{{cite journal |vauthors=Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D | title = A human RNA polymerase II complex containing factors that modify chromatin structure. | journal = Mol. Cell. Biol. | volume = 18 | issue = 9 | pages = 5355–63 | year = 1998 | pmid = 9710619 | pmc = 109120 | doi =  }}
-*{{cite journal  | author=Scully R, Anderson SF, Chao DM, ''et al.'' |title=BRCA1 is a component of the RNA polymerase II holoenzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 11 |pages= 5605-10 |year= 1997 |pmid= 9159119 |doi=  }}
+*{{cite journal |vauthors=Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D | title = NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. | journal = Mol. Cell | volume = 2 | issue = 2 | pages = 213–22 | year = 1998 | pmid = 9734358 | doi = 10.1016/S1097-2765(00)80131-8 }}
-*{{cite journal  | author=Pan G, Aso T, Greenblatt J |title=Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24563-71 |year= 1997 |pmid= 9305922 |doi=  }}
+*{{cite journal |vauthors=Garriga J, Peng J, Parreño M, Price DH, Henderson EE, Graña X | title = Upregulation of cyclin T1/CDK9 complexes during T cell activation. | journal = Oncogene | volume = 17 | issue = 24 | pages = 3093–102 | year = 1999 | pmid = 9872325 | doi = 10.1038/sj.onc.1202548 }}
-*{{cite journal  | author=Cho H, Orphanides G, Sun X, ''et al.'' |title=A human RNA polymerase II complex containing factors that modify chromatin structure. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5355-63 |year= 1998 |pmid= 9710619 |doi=  }}
+*{{cite journal |vauthors=Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J, Roeder RG | title = A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. | journal = Mol. Cell | volume = 3 | issue = 1 | pages = 97–108 | year = 1999 | pmid = 10024883 | doi = 10.1016/S1097-2765(00)80178-1 }}
-*{{cite journal  | author=Sun X, Zhang Y, Cho H, ''et al.'' |title=NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. |journal=Mol. Cell |volume=2 |issue= 2 |pages= 213-22 |year= 1998 |pmid= 9734358 |doi=  }}
+*{{cite journal |vauthors=Ramanathan Y, Rajpara SM, Reza SM, Lees E, Shuman S, Mathews MB, Pe'ery T | title = Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences. | journal = J. Biol. Chem. | volume = 276 | issue = 14 | pages = 10913–20 | year = 2001 | pmid = 11278802 | doi = 10.1074/jbc.M010975200 }}
-*{{cite journal  | author=Garriga J, Peng J, Parreño M, ''et al.'' |title=Upregulation of cyclin T1/CDK9 complexes during T cell activation. |journal=Oncogene |volume=17 |issue= 24 |pages= 3093-102 |year= 1999 |pmid= 9872325 |doi= 10.1038/sj.onc.1202548 }}
+*{{cite journal |vauthors=Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs. | journal = Genome Res. | volume = 11 | issue = 10 | pages = 1758–65 | year = 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}
-*{{cite journal  | author=Gu W, Malik S, Ito M, ''et al.'' |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97-108 |year= 1999 |pmid= 10024883 |doi=  }}
+*{{cite journal |vauthors=Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG | title = Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. | journal = Nature | volume = 417 | issue = 6888 | pages = 563–7 | year = 2002 | pmid = 12037571 | doi = 10.1038/417563a }}
-*{{cite journal  | author=Ramanathan Y, Rajpara SM, Reza SM, ''et al.'' |title=Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences. |journal=J. Biol. Chem. |volume=276 |issue= 14 |pages= 10913-20 |year= 2001 |pmid= 11278802 |doi= 10.1074/jbc.M010975200 }}
+*{{cite journal |vauthors=Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW | title = A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. | journal = J. Biol. Chem. | volume = 278 | issue = 50 | pages = 49671–4 | year = 2004 | pmid = 14576168 | doi = 10.1074/jbc.C300444200 }}
-*{{cite journal  | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
+*{{cite journal |vauthors=Wallberg AE, Yamamura S, Malik S, Spiegelman BM, Roeder RG | title = Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. | journal = Mol. Cell | volume = 12 | issue = 5 | pages = 1137–49 | year = 2004 | pmid = 14636573 | doi = 10.1016/S1097-2765(03)00391-5 }}
-*{{cite journal  | author=Ge K, Guermah M, Yuan CX, ''et al.'' |title=Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. |journal=Nature |volume=417 |issue= 6888 |pages= 563-7 |year= 2002 |pmid= 12037571 |doi= 10.1038/417563a }}
+*{{cite journal |vauthors=Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. | journal = J. Biol. Chem. | volume = 279 | issue = 7 | pages = 5846–51 | year = 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal |vauthors=Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC | title = A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. | journal = Mol. Cell | volume = 14 | issue = 5 | pages = 685–91 | year = 2004 | pmid = 15175163 | doi = 10.1016/j.molcel.2004.05.006 }}
-*{{cite journal  | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671-4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 }}
+*{{cite journal |vauthors=Nevado J, Tenbaum SP, Aranda A | title = hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor. | journal = Mol. Cell. Endocrinol. | volume = 222 | issue = 1-2 | pages = 41–51 | year = 2005 | pmid = 15249124 | doi = 10.1016/j.mce.2004.05.003 }}
-*{{cite journal  | author=Wallberg AE, Yamamura S, Malik S, ''et al.'' |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1137-49 |year= 2004 |pmid= 14636573 |doi=  }}
-*{{cite journal  | author=Tomomori-Sato C, Sato S, Parmely TJ, ''et al.'' |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846-51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 }}
-*{{cite journal  | author=Sato S, Tomomori-Sato C, Parmely TJ, ''et al.'' |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685-91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006 }}
-*{{cite journal  | author=Nevado J, Tenbaum SP, Aranda A |title=hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor. |journal=Mol. Cell. Endocrinol. |volume=222 |issue= 1-2 |pages= 41-51 |year= 2005 |pmid= 15249124 |doi= 10.1016/j.mce.2004.05.003 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-}}
 {{refend}}
-{{protein-stub}}
-{{WikiDoc Sources}}
+{{Gene-12-stub}}

MED21: Difference between revisions

Latest revision as of 06:20, 4 September 2017

Interactions

References

Further reading

Navigation menu