TMEM123: Difference between revisions

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'''Porimin''' is a [[protein]] that in humans is encoded by the ''TMEM123'' [[gene]].<ref name="pmid11481458">{{cite journal | vauthors = Ma F, Zhang C, Prasad KV, Freeman GJ, Schlossman SF | title = Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 17 | pages = 9778–83 |date=Aug 2001 | pmid = 11481458 | pmc = 55529 | doi = 10.1073/pnas.171322898 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TMEM123 transmembrane protein 123| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114908| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Transmembrane protein 123
| HGNCid = 30138
| Symbol = TMEM123
| AltSymbols =; PORMIN; KCT3; PORIMIN
| OMIM = 606356
| ECnumber = 
| Homologene = 14177
| MGIid = 1919179
| GeneAtlas_image1 = PBB_GE_TMEM123_211967_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 114908
    | Hs_Ensembl = ENSG00000152558
    | Hs_RefseqProtein = NP_443164
    | Hs_RefseqmRNA = NM_052932
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 101772277
    | Hs_GenLoc_end = 101828780
    | Hs_Uniprot = Q8N131
    | Mm_EntrezGene = 71929
    | Mm_Ensembl = ENSMUSG00000050912
    | Mm_RefseqmRNA = XM_001005696
    | Mm_RefseqProtein = XP_001005696
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 7764641
    | Mm_GenLoc_end = 7794851
    | Mm_Uniprot = Q91Z22
  }}
}}
'''Transmembrane protein 123''', also known as '''TMEM123''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TMEM123 transmembrane protein 123| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114908| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.<ref name="entrez">{{cite web | title = Entrez Gene: TMEM123 transmembrane protein 123| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114908| accessdate = }}</ref>
| summary_text = This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.<ref name="entrez">{{cite web | title = Entrez Gene: TMEM123 transmembrane protein 123| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114908| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Dekker J, Rossen JW, Büller HA, Einerhand AW |title=The MUC family: an obituary. |journal=Trends Biochem. Sci. |volume=27 |issue= 3 |pages= 126-31 |year= 2002 |pmid= 11893509 |doi=  }}
*{{cite journal  | vauthors=Dekker J, Rossen JW, Büller HA, Einerhand AW |title=The MUC family: an obituary. |journal=Trends Biochem. Sci. |volume=27 |issue= 3 |pages= 126–31 |year= 2002 |pmid= 11893509 |doi=10.1016/S0968-0004(01)02052-7 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Zhang C, Xu Y, Gu J, Schlossman SF |title=A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 11 |pages= 6290-5 |year= 1998 |pmid= 9600958 |doi= }}
*{{cite journal  | vauthors=Zhang C, Xu Y, Gu J, Schlossman SF |title=A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 11 |pages= 6290–5 |year= 1998 |pmid= 9600958 |doi=10.1073/pnas.95.11.6290  | pmc=27661  }}
*{{cite journal  | author=Ma F, Zhang C, Prasad KV, ''et al.'' |title=Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 17 |pages= 9778-83 |year= 2001 |pmid= 11481458 |doi= 10.1073/pnas.171322898 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Bonkobara M, Das A, Takao J, etal |title=Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. |journal=Br. J. Dermatol. |volume=148 |issue= 4 |pages= 654–64 |year= 2003 |pmid= 12752121 |doi=10.1046/j.1365-2133.2003.05244.x }}
*{{cite journal | author=Bonkobara M, Das A, Takao J, ''et al.'' |title=Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. |journal=Br. J. Dermatol. |volume=148 |issue= 4 |pages= 654-64 |year= 2003 |pmid= 12752121 |doi=  }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
}}
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Latest revision as of 11:59, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Porimin is a protein that in humans is encoded by the TMEM123 gene.[1][2]

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.[2]

References

  1. ↑ Ma F, Zhang C, Prasad KV, Freeman GJ, Schlossman SF (Aug 2001). "Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death". Proc Natl Acad Sci U S A. 98 (17): 9778–83. doi:10.1073/pnas.171322898. PMC 55529. PMID 11481458.
  2. ↑ 2.0 2.1 "Entrez Gene: TMEM123 transmembrane protein 123".

Further reading



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