ACRV1: Difference between revisions

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Latest revision as of 17:44, 29 August 2017

Acrosomal protein SP-10 is a protein that in humans is encoded by the ACRV1 gene.^[1]^[2]^[3]

This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. This gene consists of 4 exons and its alternative splicing generates multiple distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans.^[3]

References

↑ Wright RM, John E, Klotz K, Flickinger CJ, Herr JC (Jul 1990). "Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10". Biol Reprod. 42 (4): 693–701. doi:10.1095/biolreprod42.4.693. PMID 1693291.
↑ Golden WL, von Kap-Herr C, Kurth B, Wright RM, Flickinger CJ, Eddy R, Shows T, Herr JC (Feb 1994). "Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23→q24 of chromosome 11 by nonisotopic in situ hybridization". Genomics. 18 (2): 446–9. doi:10.1006/geno.1993.1496. PMID 8288254.
↑ ^3.0 ^3.1 "Entrez Gene: ACRV1 acrosomal vesicle protein 1".

External links

Human ACRV1 genome location and ACRV1 gene details page in the UCSC Genome Browser.

Herr JC, Klotz K, Shannon J, et al. (1992). "Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes". Biol. Reprod. 47 (1): 11–20. doi:10.1095/biolreprod47.1.11. PMID 1637938.
Homyk M, Anderson DJ, Wolff H, Herr JC (1990). "Differential diagnosis of immature germ cells in semen utilizing monoclonal antibody MHS-10 to the intra-acrosomal antigen SP-10". Fertil. Steril. 53 (2): 323–30. PMID 2298314.
Freemerman AJ, Flickinger CJ, Herr JC (1995). "Characterization of alternatively spliced human SP-10 mRNAs". Mol. Reprod. Dev. 41 (1): 100–8. doi:10.1002/mrd.1080410115. PMID 7619499.
Foster JA, Klotz KL, Flickinger CJ, et al. (1995). "Human SP-10: acrosomal distribution, processing, and fate after the acrosome reaction". Biol. Reprod. 51 (6): 1222–31. doi:10.1095/biolreprod51.6.1222. PMID 7888499.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Wright RM, Suri AK, Kornreich B, et al. (1993). "Cloning and characterization of the gene coding for the human acrosomal protein SP-10". Biol. Reprod. 49 (2): 316–25. doi:10.1095/biolreprod49.2.316. PMID 8373955.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Reddi PP, Shore AN, Acharya KK, Herr JC (2002). "Transcriptional regulation of spermiogenesis: insights from the study of the gene encoding the acrosomal protein SP-10". J. Reprod. Immunol. 53 (1–2): 25–36. doi:10.1016/S0165-0378(01)00104-8. PMID 11730901.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[pmid1693291-1] Wright RM, John E, Klotz K, Flickinger CJ, Herr JC (Jul 1990). "Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10". Biol Reprod. 42 (4): 693–701. doi:10.1095/biolreprod42.4.693. PMID 1693291.

[pmid8288254-2] Golden WL, von Kap-Herr C, Kurth B, Wright RM, Flickinger CJ, Eddy R, Shows T, Herr JC (Feb 1994). "Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23→q24 of chromosome 11 by nonisotopic in situ hybridization". Genomics. 18 (2): 446–9. doi:10.1006/geno.1993.1496. PMID 8288254.

[entrez-3] 3.0 ^3.1 "Entrez Gene: ACRV1 acrosomal vesicle protein 1".

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[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Acrosomal protein SP-10''' is a [[protein]] that in [[human]]s is encoded by the ''ACRV1'' [[gene]].<ref name="pmid1693291">{{cite journal | vauthors = Wright RM, John E, Klotz K, Flickinger CJ, Herr JC | title = Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10 | journal = Biol Reprod | volume = 42 | issue = 4 | pages = 693–701 |date=Jul 1990 | pmid = 1693291 | pmc =  | doi =10.1095/biolreprod42.4.693  }}</ref><ref name="pmid8288254">{{cite journal | vauthors = Golden WL, von Kap-Herr C, Kurth B, Wright RM, Flickinger CJ, Eddy R, Shows T, Herr JC | title = Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23→q24 of chromosome 11 by nonisotopic in situ hybridization | journal = Genomics | volume = 18 | issue = 2 | pages = 446–9 |date=Feb 1994 | pmid = 8288254 | pmc =  | doi = 10.1006/geno.1993.1496 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ACRV1 acrosomal vesicle protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Acrosomal vesicle protein 1
- | HGNCid = 127
- | Symbol = ACRV1
- | AltSymbols =; D11S4365; SP-10; SPACA2
- | OMIM = 102525
- | ECnumber =
-  | Homologene = 1219
- | MGIid = 104590
- | GeneAtlas_image1 = PBB_GE_ACRV1_208013_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_ACRV1_206776_x_at_tn.png
- | GeneAtlas_image3 = PBB_GE_ACRV1_207969_x_at_tn.png
-  | Function =
- | Component = {{GNF_GO|id=GO:0001669 |text = acrosome}}
- | Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 56
-    | Hs_Ensembl = ENSG00000134940
-    | Hs_RefseqProtein = NP_001603
-    | Hs_RefseqmRNA = NM_001612
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 11
-    | Hs_GenLoc_start = 125047440
-    | Hs_GenLoc_end = 125056152
-    | Hs_Uniprot = P26436
-    | Mm_EntrezGene = 11451
-    | Mm_Ensembl = ENSMUSG00000032110
-    | Mm_RefseqmRNA = NM_007391
-    | Mm_RefseqProtein = NP_031417
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 9
-    | Mm_GenLoc_start = 36442891
-    | Mm_GenLoc_end = 36448508
-    | Mm_Uniprot = P50289
-  }}
-}}
-'''Acrosomal vesicle protein 1''', also known as '''ACRV1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ACRV1 acrosomal vesicle protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. This gene consists of 4 exons and its alternative splicing generates multiple distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for &lt; 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans.<ref name="entrez">{{cite web | title = Entrez Gene: ACRV1 acrosomal vesicle protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56| accessdate = }}</ref>
+| summary_text = This gene encodes a [[testis]]-specific, differentiation [[antigen]], [[acrosomal]] [[Vesicle (biology)|vesicle]] protein 1, that arises within the acrosomal vesicle during [[spermatogenesis]], and is associated with the acrosomal [[Biological membrane|membrane]]s and matrix of mature sperm. This gene consists of 4 [[exon]]s and its alternative splicing generates multiple distinct transcripts, which encode protein [[isoform]]s ranging from 81 to 265 [[amino acid]]s. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for &lt; 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and [[exon skipping]] occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive [[vaccine]] [[immunogen]] for humans.<ref name="entrez"/>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|ACRV1}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Herr JC, Klotz K, Shannon J, ''et al.'' |title=Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes. |journal=Biol. Reprod. |volume=47 |issue= 1 |pages= 11-20 |year= 1992 |pmid= 1637938 |doi=  }}
+*{{cite journal  | vauthors=Herr JC, Klotz K, Shannon J |title=Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes. |journal=Biol. Reprod. |volume=47 |issue= 1 |pages= 11–20 |year= 1992 |pmid= 1637938 |doi=10.1095/biolreprod47.1.11  |display-authors=etal}}
-*{{cite journal  | author=Wright RM, John E, Klotz K, ''et al.'' |title=Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10. |journal=Biol. Reprod. |volume=42 |issue= 4 |pages= 693-701 |year= 1990 |pmid= 1693291 |doi=  }}
+*{{cite journal  | vauthors=Homyk M, Anderson DJ, Wolff H, Herr JC |title=Differential diagnosis of immature germ cells in semen utilizing monoclonal antibody MHS-10 to the intra-acrosomal antigen SP-10. |journal=Fertil. Steril. |volume=53 |issue= 2 |pages= 323–30 |year= 1990 |pmid= 2298314 |doi=  }}
-*{{cite journal  | author=Homyk M, Anderson DJ, Wolff H, Herr JC |title=Differential diagnosis of immature germ cells in semen utilizing monoclonal antibody MHS-10 to the intra-acrosomal antigen SP-10. |journal=Fertil. Steril. |volume=53 |issue= 2 |pages= 323-30 |year= 1990 |pmid= 2298314 |doi=  }}
+*{{cite journal  | vauthors=Freemerman AJ, Flickinger CJ, Herr JC |title=Characterization of alternatively spliced human SP-10 mRNAs. |journal=Mol. Reprod. Dev. |volume=41 |issue= 1 |pages= 100–8 |year= 1995 |pmid= 7619499 |doi= 10.1002/mrd.1080410115 }}
-*{{cite journal  | author=Freemerman AJ, Flickinger CJ, Herr JC |title=Characterization of alternatively spliced human SP-10 mRNAs. |journal=Mol. Reprod. Dev. |volume=41 |issue= 1 |pages= 100-8 |year= 1995 |pmid= 7619499 |doi= 10.1002/mrd.1080410115 }}
+*{{cite journal  | vauthors=Foster JA, Klotz KL, Flickinger CJ |title=Human SP-10: acrosomal distribution, processing, and fate after the acrosome reaction. |journal=Biol. Reprod. |volume=51 |issue= 6 |pages= 1222–31 |year= 1995 |pmid= 7888499 |doi=10.1095/biolreprod51.6.1222  |display-authors=etal}}
-*{{cite journal  | author=Foster JA, Klotz KL, Flickinger CJ, ''et al.'' |title=Human SP-10: acrosomal distribution, processing, and fate after the acrosome reaction. |journal=Biol. Reprod. |volume=51 |issue= 6 |pages= 1222-31 |year= 1995 |pmid= 7888499 |doi=  }}
+*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  | vauthors=Wright RM, Suri AK, Kornreich B |title=Cloning and characterization of the gene coding for the human acrosomal protein SP-10 |journal=Biol. Reprod. |volume=49 |issue= 2 |pages= 316–25 |year= 1993 |pmid= 8373955 |doi=10.1095/biolreprod49.2.316  |display-authors=etal}}
-*{{cite journal  | author=Golden WL, von Kap-Herr C, Kurth B, ''et al.'' |title=Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23-->q24 of chromosome 11 by nonisotopic in situ hybridization. |journal=Genomics |volume=18 |issue= 2 |pages= 446-9 |year= 1994 |pmid= 8288254 |doi= 10.1006/geno.1993.1496 }}
+*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
-*{{cite journal  | author=Wright RM, Suri AK, Kornreich B, ''et al.'' |title=Cloning and characterization of the gene coding for the human acrosomal protein SP-10. |journal=Biol. Reprod. |volume=49 |issue= 2 |pages= 316-25 |year= 1993 |pmid= 8373955 |doi=  }}
+*{{cite journal  | vauthors=Reddi PP, Shore AN, Acharya KK, Herr JC |title=Transcriptional regulation of spermiogenesis: insights from the study of the gene encoding the acrosomal protein SP-10 |journal=J. Reprod. Immunol. |volume=53 |issue= 1–2 |pages= 25–36 |year= 2002 |pmid= 11730901 |doi=10.1016/S0165-0378(01)00104-8  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Reddi PP, Shore AN, Acharya KK, Herr JC |title=Transcriptional regulation of spermiogenesis: insights from the study of the gene encoding the acrosomal protein SP-10. |journal=J. Reprod. Immunol. |volume=53 |issue= 1-2 |pages= 25-36 |year= 2002 |pmid= 11730901 |doi=  }}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
 }}
 {{refend}}
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+{{PBB_Controls
+| update_page = yes
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+[[Category:Human proteins]]
+{{gene-11-stub}}

ACRV1: Difference between revisions

Latest revision as of 17:44, 29 August 2017

References

External links

Further reading

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